Refined structure (7T11) of Gi3 - SST2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (61.6%), 136 from model (38.4%)
Residue sidechains - 153 from structure (43.2%), 201 from model (56.8%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure AF2
G.HN 4 T G.HN.10 Structure AF2
G.HN 5 L G.HN.11 Structure AF2
G.HN 6 S G.HN.30 Structure AF2
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure AF2
G.HN 9 D G.HN.33 Structure AF2
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure AF2
G.HN 25 E G.HN.49 Structure AF2
G.HN 26 D G.HN.50 Structure AF2
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure AF2
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 K G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure AF2
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure AF2
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure AF2
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure AF2
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure AF2
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 D G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 D H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 V H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 E H.hahb.08 AF2 AF2
H.hahb 98 A H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 S H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 V H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 P H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 R H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 G H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 S H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 S H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 S H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 S H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure AF2
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 Y G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure AF2
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure AF2
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure AF2
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure AF2
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure AF2
G.s4h3 232 L G.s4h3.06 Structure AF2
G.s4h3 233 V G.s4h3.07 AF2 AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 E G.h3s5.02 Structure AF2
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure AF2
G.HG 271 K G.HG.01 Structure AF2
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure AF2
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure AF2
G.HG 276 E G.HG.06 Structure AF2
G.HG 277 K G.HG.07 Structure AF2
G.HG 278 I G.HG.08 Structure AF2
G.HG 279 K G.HG.09 Structure AF2
G.HG 280 R G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure AF2
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure AF2
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 T G.hgh4.06 Structure AF2
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure AF2
G.H4 294 N G.H4.01 Structure AF2
G.H4 295 T G.H4.02 Structure AF2
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure AF2
G.H4 298 E G.H4.05 Structure AF2
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure AF2
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure AF2
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 R G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure AF2
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure AF2
G.s6h5 325 C G.s6h5.02 Structure AF2
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure AF2
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure AF2
G.H5 330 K G.H5.02 Structure AF2
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure AF2
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 E G.H5.22 Structure AF2
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 Y G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 285 from structure (84.3%), 53 from model (15.7%)
Residue sidechains - 222 from structure (65.7%), 116 from model (34.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 M - AF2 AF2
N-term 4 A - AF2 AF2
N-term 5 D - AF2 AF2
N-term 6 E - AF2 AF2
N-term 7 P - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 N - AF2 AF2
N-term 10 G - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 H - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 W - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 I - AF2 AF2
N-term 18 P - AF2 AF2
N-term 19 F - AF2 AF2
N-term 20 D - AF2 AF2
N-term 21 L - AF2 AF2
N-term 22 N - AF2 AF2
N-term 23 G - AF2 AF2
N-term 24 S - AF2 AF2
N-term 25 V - AF2 AF2
N-term 26 V - AF2 AF2
N-term 27 S - AF2 AF2
N-term 28 T - AF2 AF2
N-term 29 N - AF2 AF2
N-term 30 T - AF2 AF2
N-term 31 S - AF2 AF2
N-term 32 N - AF2 AF2
N-term 33 Q - AF2 AF2
N-term 34 T - AF2 AF2
N-term 35 E - AF2 AF2
N-term 36 P - AF2 AF2
N-term 37 Y - AF2 AF2
N-term 38 Y - AF2 AF2
N-term 39 D - AF2 AF2
TM1 40 L 1.29x29 AF2 AF2
TM1 41 T 1.30x30 AF2 AF2
TM1 42 S 1.31x31 AF2 AF2
TM1 43 N 1.32x32 Structure AF2
TM1 44 A 1.33x33 Structure Structure
TM1 45 V 1.34x34 Structure AF2
TM1 46 L 1.35x35 Structure AF2
TM1 47 T 1.36x36 Structure AF2
TM1 48 F 1.37x37 Structure AF2
TM1 49 I 1.38x38 Structure AF2
TM1 50 Y 1.39x39 Structure Structure
TM1 51 F 1.40x40 Structure Structure
TM1 52 V 1.41x41 Structure Structure
TM1 53 V 1.42x42 Structure Structure
TM1 54 C 1.43x43 Structure Structure
TM1 55 I 1.44x44 Structure Structure
TM1 56 I 1.45x45 Structure Structure
TM1 57 G 1.46x46 Structure Structure
TM1 58 L 1.47x47 Structure Structure
TM1 59 C 1.48x48 Structure Structure
TM1 60 G 1.49x49 Structure Structure
TM1 61 N 1.50x50 Structure Structure
TM1 62 T 1.51x51 Structure Structure
TM1 63 L 1.52x52 Structure Structure
TM1 64 V 1.53x53 Structure Structure
TM1 65 I 1.54x54 Structure Structure
TM1 66 Y 1.55x55 Structure Structure
TM1 67 V 1.56x56 Structure Structure
TM1 68 I 1.57x57 Structure Structure
TM1 69 L 1.58x58 Structure Structure
TM1 70 R 1.59x59 Structure AF2
TM1 71 Y 1.60x60 Structure AF2
ICL1 72 A 12.48x48 Structure Structure
ICL1 73 K 12.49x49 Structure AF2
ICL1 74 M 12.50x50 Structure AF2
ICL1 75 K 12.51x51 Structure AF2
TM2 76 T 2.37x37 Structure Structure
TM2 77 I 2.38x38 Structure Structure
TM2 78 T 2.39x39 Structure Structure
TM2 79 N 2.40x40 Structure Structure
TM2 80 I 2.41x41 Structure Structure
TM2 81 Y 2.42x42 Structure Structure
TM2 82 I 2.43x43 Structure Structure
TM2 83 L 2.44x44 Structure Structure
TM2 84 N 2.45x45 Structure Structure
TM2 85 L 2.46x46 Structure Structure
TM2 86 A 2.47x47 Structure Structure
TM2 87 I 2.48x48 Structure Structure
TM2 88 A 2.49x49 Structure Structure
TM2 89 D 2.50x50 Structure Structure
TM2 90 E 2.51x51 Structure Structure
TM2 91 L 2.52x52 Structure Structure
TM2 92 F 2.53x53 Structure Structure
TM2 93 M 2.54x54 Structure Structure
TM2 94 L 2.55x55 Structure Structure
TM2 95 G 2.56x56 Structure Structure
TM2 96 L 2.57x57 Structure AF2
TM2 97 P 2.58x58 Structure Structure
TM2 98 F 2.59x59 Structure Structure
TM2 99 L 2.60x60 Structure Structure
TM2 100 A 2.61x61 Structure Structure
TM2 101 M 2.62x62 Structure Structure
TM2 102 Q 2.63x63 Structure Structure
TM2 103 V 2.64x64 Structure Structure
TM2 104 A 2.65x65 Structure Structure
TM2 105 L 2.66x66 Structure AF2
ECL1 106 V - Structure AF2
ECL1 107 H 23.49x49 Structure Structure
ECL1 108 W 23.50x50 Structure Structure
ECL1 109 P 23.51x51 Structure Structure
ECL1 110 F 23.52x52 Structure AF2
TM3 111 G 3.21x21 Structure Structure
TM3 112 K 3.22x22 Structure AF2
TM3 113 A 3.23x23 Structure Structure
TM3 114 I 3.24x24 Structure AF2
TM3 115 C 3.25x25 Structure Structure
TM3 116 R 3.26x26 Structure Structure
TM3 117 V 3.27x27 Structure AF2
TM3 118 V 3.28x28 Structure Structure
TM3 119 M 3.29x29 Structure Structure
TM3 120 T 3.30x30 Structure Structure
TM3 121 V 3.31x31 Structure Structure
TM3 122 D 3.32x32 Structure Structure
TM3 123 G 3.33x33 Structure Structure
TM3 124 I 3.34x34 Structure AF2
TM3 125 N 3.35x35 Structure Structure
TM3 126 Q 3.36x36 Structure Structure
TM3 127 F 3.37x37 Structure Structure
TM3 128 T 3.38x38 Structure Structure
TM3 129 S 3.39x39 Structure Structure
TM3 130 I 3.40x40 Structure Structure
TM3 131 F 3.41x41 Structure Structure
TM3 132 C 3.42x42 Structure Structure
TM3 133 L 3.43x43 Structure Structure
TM3 134 T 3.44x44 Structure Structure
TM3 135 V 3.45x45 Structure Structure
TM3 136 M 3.46x46 Structure Structure
TM3 137 S 3.47x47 Structure Structure
TM3 138 I 3.48x48 Structure Structure
TM3 139 D 3.49x49 Structure Structure
TM3 140 R 3.50x50 Structure Structure
TM3 141 Y 3.51x51 Structure Structure
TM3 142 L 3.52x52 Structure Structure
TM3 143 A 3.53x53 Structure Structure
TM3 144 V 3.54x54 Structure Structure
TM3 145 V 3.55x55 Structure Structure
TM3 146 H 3.56x56 Structure Structure
ICL2 147 P 34.50x50 Structure Structure
ICL2 148 I 34.51x51 Structure Structure
ICL2 149 K 34.52x52 Structure AF2
ICL2 150 S 34.53x53 Structure Structure
ICL2 151 A 34.54x54 Structure Structure
ICL2 152 K 34.55x55 Structure AF2
ICL2 153 W 34.56x56 Structure AF2
ICL2 154 R 34.57x57 Structure Structure
TM4 155 R 4.38x38 Structure AF2
TM4 156 P 4.39x39 Structure Structure
TM4 157 R 4.40x40 Structure AF2
TM4 158 T 4.41x41 Structure Structure
TM4 159 A 4.42x42 Structure Structure
TM4 160 K 4.43x43 Structure AF2
TM4 161 M 4.44x44 Structure Structure
TM4 162 I 4.45x45 Structure Structure
TM4 163 T 4.46x46 Structure Structure
TM4 164 M 4.47x47 Structure AF2
TM4 165 A 4.48x48 Structure Structure
TM4 166 V 4.49x49 Structure Structure
TM4 167 W 4.50x50 Structure Structure
TM4 168 G 4.51x51 Structure Structure
TM4 169 V 4.52x52 Structure Structure
TM4 170 S 4.53x53 Structure Structure
TM4 171 L 4.54x54 Structure Structure
TM4 172 L 4.55x55 Structure AF2
TM4 173 V 4.56x56 Structure Structure
TM4 174 I 4.57x57 Structure Structure
TM4 175 L 4.58x59 Structure Structure
TM4 176 P 4.59x60 Structure Structure
TM4 177 I 4.60x61 Structure Structure
TM4 178 M 4.61x62 Structure Structure
TM4 179 I 4.62x63 Structure Structure
TM4 180 Y 4.63x64 Structure Structure
TM4 181 A 4.64x65 Structure Structure
ECL2 182 G - Structure Structure
ECL2 183 L - Structure Structure
ECL2 184 R - Structure Structure
ECL2 185 S - Structure Structure
ECL2 186 N - Structure Structure
ECL2 187 Q - Structure AF2
ECL2 188 W - Structure Structure
ECL2 189 G - Structure Structure
ECL2 190 R - Structure AF2
ECL2 191 S - Structure Structure
ECL2 192 S - Structure Structure
ECL2 193 C 45.50x50 Structure Structure
ECL2 194 T 45.51x51 Structure Structure
ECL2 195 I 45.52x52 Structure Structure
ECL2 196 N - Structure Structure
ECL2 197 W - Structure Structure
ECL2 198 P - Structure Structure
ECL2 199 G - Structure Structure
ECL2 200 E - Structure AF2
TM5 201 S 5.31x32 Structure Structure
TM5 202 G 5.32x33 Structure Structure
TM5 203 A 5.33x34 Structure Structure
TM5 204 W 5.34x35 Structure AF2
TM5 205 Y 5.35x36 Structure Structure
TM5 206 T 5.36x37 Structure AF2
TM5 207 G 5.37x38 Structure Structure
TM5 208 F 5.38x39 Structure Structure
TM5 209 I 5.39x40 Structure Structure
TM5 210 I 5.40x41 Structure Structure
TM5 211 Y 5.41x42 Structure Structure
TM5 212 T 5.42x43 Structure Structure
TM5 213 F 5.43x44 Structure Structure
TM5 214 I 5.44x45 Structure Structure
TM5 215 L 5.45x46 Structure Structure
TM5 216 G 5.46x461 Structure Structure
TM5 217 F 5.47x47 Structure Structure
TM5 218 L 5.48x48 Structure Structure
TM5 219 V 5.49x49 Structure Structure
TM5 220 P 5.50x50 Structure Structure
TM5 221 L 5.51x51 Structure Structure
TM5 222 T 5.52x52 Structure Structure
TM5 223 I 5.53x53 Structure Structure
TM5 224 I 5.54x54 Structure Structure
TM5 225 C 5.55x55 Structure Structure
TM5 226 L 5.56x56 Structure Structure
TM5 227 C 5.57x57 Structure Structure
TM5 228 Y 5.58x58 Structure Structure
TM5 229 L 5.59x59 Structure Structure
TM5 230 F 5.60x60 Structure Structure
TM5 231 I 5.61x61 Structure Structure
TM5 232 I 5.62x62 Structure Structure
TM5 233 I 5.63x63 Structure Structure
TM5 234 K 5.64x64 Structure Structure
TM5 235 V 5.65x65 Structure Structure
TM5 236 K 5.66x66 Structure AF2
TM5 237 S 5.67x67 Structure Structure
TM5 238 S 5.68x68 Structure AF2
ICL3 239 G - Structure AF2
ICL3 240 I - Structure AF2
ICL3 241 R - Structure AF2
ICL3 242 V - Structure AF2
ICL3 243 G - Structure Structure
TM6 244 S 6.23x23 Structure Structure
TM6 245 S 6.24x24 Structure AF2
TM6 246 K 6.25x25 Structure AF2
TM6 247 R 6.26x26 Structure AF2
TM6 248 K 6.27x27 Structure AF2
TM6 249 K 6.28x28 Structure AF2
TM6 250 S 6.29x29 Structure AF2
TM6 251 E 6.30x30 Structure AF2
TM6 252 K 6.31x31 Structure AF2
TM6 253 K 6.32x32 Structure AF2
TM6 254 V 6.33x33 Structure Structure
TM6 255 T 6.34x34 Structure Structure
TM6 256 R 6.35x35 Structure AF2
TM6 257 M 6.36x36 Structure AF2
TM6 258 V 6.37x37 Structure AF2
TM6 259 S 6.38x38 Structure Structure
TM6 260 I 6.39x39 Structure Structure
TM6 261 V 6.40x40 Structure Structure
TM6 262 V 6.41x41 Structure Structure
TM6 263 A 6.42x42 Structure Structure
TM6 264 V 6.43x43 Structure Structure
TM6 265 F 6.44x44 Structure Structure
TM6 266 I 6.45x45 Structure Structure
TM6 267 F 6.46x46 Structure Structure
TM6 268 C 6.47x47 Structure Structure
TM6 269 W 6.48x48 Structure Structure
TM6 270 L 6.49x49 Structure Structure
TM6 271 P 6.50x50 Structure Structure
TM6 272 F 6.51x51 Structure Structure
TM6 273 Y 6.52x52 Structure Structure
TM6 274 I 6.53x53 Structure Structure
TM6 275 F 6.54x54 Structure Structure
TM6 276 N 6.55x55 Structure Structure
TM6 277 V 6.56x56 Structure Structure
TM6 278 S 6.57x57 Structure Structure
TM6 279 S 6.58x58 Structure Structure
TM6 280 V 6.59x59 Structure AF2
TM6 281 S 6.60x60 Structure Structure
TM6 282 M 6.61x61 Structure AF2
ECL3 283 A - Structure Structure
ECL3 284 I - Structure Structure
ECL3 285 S - Structure Structure
ECL3 286 P - Structure Structure
TM7 287 T 7.28x27 Structure AF2
TM7 288 P 7.29x28 Structure Structure
TM7 289 A 7.30x29 Structure Structure
TM7 290 L 7.31x30 Structure Structure
TM7 291 K 7.32x31 Structure Structure
TM7 292 G 7.33x32 Structure Structure
TM7 293 M 7.34x33 Structure AF2
TM7 294 F 7.35x34 Structure Structure
TM7 295 D 7.36x35 Structure Structure
TM7 296 F 7.37x36 Structure Structure
TM7 297 V 7.38x37 Structure Structure
TM7 298 V 7.39x38 Structure Structure
TM7 299 V 7.40x39 Structure Structure
TM7 300 L 7.41x40 Structure Structure
TM7 301 T 7.42x41 Structure Structure
TM7 302 Y 7.43x42 Structure Structure
TM7 303 A 7.44x43 Structure Structure
TM7 304 N 7.45x45 Structure Structure
TM7 305 S 7.46x46 Structure Structure
TM7 306 C 7.47x47 Structure Structure
TM7 307 A 7.48x48 Structure Structure
TM7 308 N 7.49x49 Structure Structure
TM7 309 P 7.50x50 Structure Structure
TM7 310 I 7.51x51 Structure Structure
TM7 311 L 7.52x52 Structure Structure
TM7 312 Y 7.53x53 Structure Structure
TM7 313 A 7.54x54 Structure Structure
TM7 314 F 7.55x55 Structure Structure
TM7 315 L 7.56x56 Structure Structure
H8 316 S 8.47x47 Structure Structure
H8 317 D 8.48x48 Structure AF2
H8 318 N 8.49x49 Structure Structure
H8 319 F 8.50x50 Structure AF2
H8 320 K 8.51x51 Structure AF2
H8 321 K 8.52x52 Structure AF2
H8 322 S 8.53x53 Structure Structure
H8 323 F 8.54x54 Structure AF2
H8 324 Q 8.55x55 Structure AF2
H8 325 N 8.56x56 Structure AF2
H8 326 V 8.57x57 Structure AF2
H8 327 L 8.58x58 Structure AF2
H8 328 C 8.59x59 AF2 AF2
C-term 329 L - AF2 AF2
C-term 330 V - AF2 AF2
C-term 331 K - AF2 AF2
C-term 332 V - AF2 AF2
C-term 333 S - AF2 AF2
C-term 334 G - AF2 AF2
C-term 335 T - AF2 AF2
C-term 336 D - AF2 AF2
C-term 337 D - AF2 AF2
C-term 338 G - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 M 257 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 257 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 247 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 247 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM6 V 254 6x33 G.H5 Y 354 G.H5.26
Hydrophobic ICL3 I 240 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 I 240 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 R 140 3x50 G.H5 L 353 G.H5.25
Polar TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 147 34x50 G.H5 I 344 G.H5.16
Polar TM6 S 244 6x23 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 S 244 6x23 G.h4s6 D 315 G.h4s6.09
Ionic TM6 K 246 6x25 G.h4s6 D 315 G.h4s6.09
Polar TM6 K 246 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 K 246 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 246 6x25 G.h4s6 D 315 G.h4s6.09
Polar ICL3 I 240 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 I 240 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 I 240 - G.h4s6 E 318 G.h4s6.12
Polar TM6 R 247 6x26 G.H5 Y 354 G.H5.26
Polar TM6 S 250 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 S 250 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 S 250 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM3 A 143 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 I 148 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL3 I 240 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 I 240 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 R 241 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 R 241 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 147 34x50 G.H5 T 340 G.H5.12
Polar ICL3 R 241 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 R 241 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 R 241 - G.H5 I 344 G.H5.16
Polar TM2 T 76 2x37 G.H5 E 350 G.H5.22
Hydrophobic TM2 T 76 2x37 G.H5 E 350 G.H5.22
Van-der-waals TM2 T 76 2x37 G.H5 E 350 G.H5.22
Hydrophobic ICL3 R 241 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 R 241 - G.H5 K 345 G.H5.17
Polar TM5 S 238 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 S 238 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 238 5x68 G.H5 D 341 G.H5.13
Polar TM3 A 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 347 G.H5.19
Ionic ICL3 R 241 - G.H5 D 341 G.H5.13
Polar ICL3 R 241 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 241 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 I 148 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 V 254 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 254 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 147 34x50 G.H5 I 343 G.H5.15
Polar ICL3 I 240 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 I 240 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 I 240 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 G 239 - G.h4s6 E 318 G.h4s6.12