SST2 receptor - Gi3

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7T11

RESOLUTION

2.7 Å

REFERENCE

10.1038/S41594-022-00727-5

PUBLICATION DATE

March 9, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

60 interactions (Click to see)

LIGANDS

Octreotide - Agonist

PHYSIOLOGICAL LIGANDS

cortistatin-14, SRIF-14, CST-17, SRIF-28



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 148 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 240 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 L 241 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 I 148 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL3 L 241 - G.H5 I 344 G.H5.16
Polar TM3 A 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 147 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL3 L 241 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 L 240 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 L 240 - G.S6 Y 320 G.S6.02
Polar TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 254 6x33 G.H5 Y 354 G.H5.26
Hydrophobic TM3 R 140 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 238 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 A 143 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 240 - G.H5 V 342 G.H5.14
Hydrophobic ICL2 P 147 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 240 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 L 240 - G.H5 K 345 G.H5.17
Hydrophobic TM6 N 250 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 N 250 6x29 G.H5 Y 354 G.H5.26
Hydrophobic ICL3 L 241 - G.H5 Y 354 G.H5.26
Hydrophobic ICL2 P 147 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 254 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 254 6x33 G.H5 L 353 G.H5.25