GPR3 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9M8V

RESOLUTION

3.8 Å

REFERENCE

PUBLICATION DATE

Sept. 24, 2025

3D VIEW

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LIGAND INTERACTIONS

10 interactions (Click to see)

LIGANDS

AF64394 - NAM pubchem

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 K 244 - G.H5 L 393 G.H5.25
Van-der-waals ICL3 K 244 - G.H5 L 393 G.H5.25
Hydrophobic ICL3 G 245 - G.H5 L 394 G.H5.26
Ionic ICL3 K 244 - G.H5 E 392 G.H5.24
Hydrophobic TM4 E 147 4x36 G.HN Q 35 G.HN.52
Van-der-waals TM4 E 147 4x36 G.HN Q 35 G.HN.52
Polar TM5 Q 226 5x71 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 226 5x71 G.H5 R 385 G.H5.17
Hydrophobic ICL2 Y 144 - G.H5 H 387 G.H5.19
Polar TM3 S 137 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 137 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 137 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL3 K 244 - G.H5 L 394 G.H5.26
Polar ICL3 G 245 - G.H5 L 393 G.H5.25
Hydrophobic ICL3 G 245 - G.H5 L 393 G.H5.25
Van-der-waals ICL3 G 245 - G.H5 L 393 G.H5.25
Hydrophobic ICL2 A 141 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 141 - G.H5 I 383 G.H5.15
Hydrophobic TM2 M 75 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM6 T 248 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 220 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 220 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 138 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 142 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 142 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 L 142 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 L 142 - G.H5 I 383 G.H5.15
Hydrophobic TM5 I 227 5x72 G.h4s6 Y 358 G.h4s6.20
Polar ICL2 Y 145 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 145 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 145 - G.H5 H 387 G.H5.19
Polar TM5 H 223 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 223 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 I 227 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 227 5x72 G.H5 R 385 G.H5.17
Ionic TM5 R 222 5x67 G.H5 D 381 G.H5.13
Hydrophobic TM5 I 216 5x61 G.H5 L 393 G.H5.25
Polar TM3 Y 139 3x55 G.H5 R 380 G.H5.12
Aromatic TM3 Y 139 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 Y 139 3x55 G.H5 R 380 G.H5.12
Aromatic ICL2 Y 145 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Y 145 - G.hns1 R 38 G.hns1.02
Polar TM3 L 138 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 138 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 142 - G.H5 R 380 G.H5.12
Aromatic TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Polar TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Polar TM5 Q 230 5x75 G.S6 C 359 G.S6.01
Hydrophobic TM5 V 220 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 220 5x65 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 142 - G.S1 H 41 G.S1.02
Ionic TM5 H 223 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 223 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 223 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 223 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM6 L 249 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 A 141 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 A 141 - G.H5 Q 384 G.H5.16
Polar TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Ionic TM7 R 300 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 138 3x54 G.H5 H 387 G.H5.19