β3-adrenoceptor (adrb3_canlf)

FAMILY

Class A (Rhodopsin) Aminergic receptors Adrenoceptors β3-adrenoceptor

GENE

ADRB3 (B3AR)

ORGANISM

Dog (Canis lupus familiaris)

ALT. NAMES

Beta-3 adrenergic receptor, Beta-3 adrenoreceptor, Beta-3 adrenoceptor

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
A
P
W
P
H
G
N
G
S
10
                   
V
A
S
W
P
A
A
P
T
P
20
                   
T
P
D
A
A
N
T
S
G
L
30
TM1              
P
G
A
P
W
A
V
A
L
A
40
                   
G
A
L
L
A
L
E
V
L
A
50
                   
T
V
G
G
N
L
L
V
I
V
60
          ICL1  
A
I
A
R
T
P
R
L
Q
T
70
TM2              
M
T
N
V
F
V
T
S
L
A
80
                   
T
A
D
L
V
V
G
L
L
V
90
                   
V
P
P
G
A
T
L
A
L
T
100
  ECL1 TM3    
G
R
W
P
L
G
A
T
G
C
110
                   
E
L
W
T
S
V
D
V
L
C
120
                   
V
T
A
S
I
E
T
L
C
A
130
                   
L
A
V
D
R
Y
L
A
V
T
140
  ICL2          
N
P
L
R
Y
G
A
L
V
T
150
TM4              
K
R
R
A
R
A
A
V
V
L
160
                   
V
W
V
V
S
A
A
V
S
F
170
            ECL2
A
P
I
M
S
K
W
W
R
V
180
                   
G
A
D
A
E
A
Q
R
C
H
190
                   
S
N
P
H
C
C
A
F
A
S
200
TM5              
N
I
P
Y
A
L
L
S
S
S
210
                   
V
S
F
Y
L
P
L
L
V
M
220
                   
L
F
V
Y
A
R
V
F
L
V
230
                   
A
T
R
Q
L
R
L
L
R
R
240
    ICL3        
E
L
G
R
F
P
P
A
E
S
250
                   
P
P
A
A
S
R
S
R
S
P
260
                   
G
P
A
R
R
C
A
S
P
A
270
                   
A
V
P
S
D
R
L
R
P
A
280
TM6              
R
L
L
P
L
R
E
H
R
A
290
                   
L
R
T
L
G
L
I
V
G
T
300
                   
F
T
L
C
W
L
P
F
F
V
310
                   
A
N
V
M
R
A
L
G
G
P
320
ECL3 TM7      
S
L
V
P
S
P
A
L
L
A
330
                   
L
N
W
L
G
Y
A
N
S
A
340
                H8
F
N
P
L
I
Y
C
R
S
P
350
                   
D
F
R
S
A
F
R
R
L
L
360
  C-term      
C
R
C
R
R
E
E
H
R
A
370
                   
A
A
S
P
P
G
D
P
S
A
380
                   
A
P
A
A
L
T
S
P
A
E
390
                   
S
S
R
C
Q
A
L
D
G
A
400
         
S
W
G
I
S

LINKS

ChEMBL

UniProt

DIAGRAMS

7TM

ICL1 P R L Q ICL1ECL1 R W P L ECL1ICL2 P L R Y G A L V ICL2ECL2 W W R V G A D A E A Q R C H S N P H C C A F A S ECL2ICL3 G R F P P A E S P P A A S R S R S P G P A R R C A S P A A V P S D R L R P A ICL3ECL3 G P S L V ECL3N-term M A P W P H G N G S V A S W P A A P T P T P D A A N T S G N-termC-term R C R R E E H R A A A S P P G D P S A A P A A L T S P A E S S R C Q A L D G A S W G I S C-term L P G A P W A V A L A G A L L A L E V L A T V G G N L L V I V A I A R T T M T N V F V T S L A T A D L V V G L L V V P P G A T L A L T G G A T G C E L W T S V D V L C V T A S I E T L C A L A V D R Y L A V T N T K R R A R A A V V L V W V V S A A V S F A P I M S K N I P Y A L L S S S V S F Y L P L L V M L F V Y A R V F L V A T R Q L R L L R R E L R L L P L R E H R A L R T L G L I V G T F T L C W L P F F V A N V M R A L G P S P A L L A L N W L G Y A N S A F N P L I Y C R S P D F R R F R S A L L C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N G G V T A L V E L A L L A G A L A V 1 T S L A T A D L V V G L L V V P P G A T L 2 A C L T E I S A T V C L V D V S T W L E 3 A R A A V V L V W V V S A A V S F A P I 4 Y V F L M V L L P L Y F S V S S S L L A Y 5 G L I V G T F T L C W L P F F V A N V M 6 L P N F A S N A Y G L W N L A L L A P 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models have been generated as experimental structures are available (see below).

STRUCTURES

Found 3 structure(s) - view all details on the Structures page

PDBs: 7DH5, 7XJH, 7XJI