SMO - Gi1

GPCR CLASS (FAMILY)

Class F (Frizzled)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Sept. 30, 2020

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

24,25-Epoxy-cholesterol - Agonist pubchem ,

24,25-Epoxy-cholesterol - PAM pubchem

ENDOGENOUS LIGANDS

No endogenous ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM2 A 264 2x41 G.H5 D 350 G.H5.22
Hydrophobic TM2 A 264 2x41 G.H5 D 350 G.H5.22
Van-der-waals TM2 A 264 2x41 G.H5 D 350 G.H5.22
Hydrophobic TM3 L 346 3x57 G.H5 L 348 G.H5.20
Hydrophobic TM3 L 346 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 346 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM6 A 441 6x22 G.H5 D 341 G.H5.13
Van-der-waals TM6 A 441 6x22 G.H5 D 341 G.H5.13
Hydrophobic TM2 P 263 2x40 G.H5 D 350 G.H5.22
Van-der-waals TM2 P 263 2x40 G.H5 D 350 G.H5.22
Hydrophobic TM3 F 343 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 F 343 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM3 F 343 3x54 G.H5 L 348 G.H5.20
Polar ICL2 T 349 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 349 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 349 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 L 346 3x57 G.H5 I 344 G.H5.16
Hydrophobic ICL3 G 435 - G.H5 F 336 G.H5.08
Hydrophobic TM3 F 343 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 F 343 3x54 G.H5 C 351 G.H5.23
Polar ICL2 T 348 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 T 348 - G.H5 N 347 G.H5.19
Hydrophobic TM6 K 444 6x25 G.H5 L 348 G.H5.20
Hydrophobic TM6 K 444 6x25 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 444 6x25 G.H5 F 354 G.H5.26
Hydrophobic TM2 R 261 2x38 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 261 2x38 G.H5 D 350 G.H5.22
Hydrophobic TM2 P 263 2x40 G.H5 C 351 G.H5.23
Polar TM3 S 342 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 342 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 S 342 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 G 347 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 G 347 - G.H5 I 343 G.H5.15
Polar TM2 R 261 2x38 G.H5 K 349 G.H5.21
Van-der-waals TM2 R 261 2x38 G.H5 K 349 G.H5.21
Hydrophobic ICL2 T 348 - G.H5 I 343 G.H5.15
Hydrophobic TM2 R 261 2x38 G.H5 G 352 G.H5.24
Van-der-waals TM2 R 261 2x38 G.H5 G 352 G.H5.24
Polar TM3 W 339 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 W 339 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 W 339 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 W 339 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 W 339 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 H 433 - G.H5 F 336 G.H5.08
Hydrophobic C-term W 535 - G.H5 L 353 G.H5.25
Van-der-waals C-term W 535 - G.H5 L 353 G.H5.25
Polar TM3 A 345 3x56 G.H5 N 347 G.H5.19
Hydrophobic ICL2 T 349 - G.H5 I 343 G.H5.15
Hydrophobic TM6 T 448 6x29 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 448 6x29 G.H5 L 353 G.H5.25
Hydrophobic TM2 A 264 2x41 G.H5 C 351 G.H5.23
Hydrophobic ICL3 G 435 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 G 435 - G.H5 D 337 G.H5.09
Polar TM6 R 451 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 451 6x32 G.H5 L 353 G.H5.25
Polar ICL3 P 434 - G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL3 P 434 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL3 P 434 - G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 G 347 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 G 347 - G.H5 I 344 G.H5.16
Van-der-waals TM6 T 448 6x29 G.H5 F 354 G.H5.26
Polar TM6 S 438 6x19 G.H5 D 341 G.H5.13
Hydrophobic TM6 S 438 6x19 G.H5 D 341 G.H5.13
Van-der-waals TM6 S 438 6x19 G.H5 D 341 G.H5.13
Hydrophobic TM6 I 445 6x26 G.H5 L 348 G.H5.20
Polar ICL3 H 433 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 H 433 - G.H5 T 340 G.H5.12
Van-der-waals ICL3 H 433 - G.H5 T 340 G.H5.12
Hydrophobic TM2 A 264 2x41 G.H5 G 352 G.H5.24
Van-der-waals TM2 A 264 2x41 G.H5 G 352 G.H5.24
Hydrophobic ICL3 P 434 - G.H5 F 336 G.H5.08