MRGPRX4 - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7S8P

RESOLUTION

2.6 Å

REFERENCE

10.1038/S41586-021-04126-6

PUBLICATION DATE

Nov. 17, 2021

3D VIEW

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LIGAND INTERACTIONS

28 interactions (Click to see)

LIGANDS

N-[(1r,3R,5S,7R)-3,5-dimethyltricyclo[3.3.1.1~3,7~]decane-1-carbonyl]-D-phenylalanine - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 S 123 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 S 123 3x53 G.H5 N 239 G.H5.19
Hydrophobic ICL2 I 128 34x51 G.S3 V 79 G.S3.01
Hydrophobic TM7 G 276 7x57 G.H5 N 244 G.H5.24
Van-der-waals TM7 G 276 7x57 G.H5 N 244 G.H5.24
Hydrophobic ICL1 N 59 - G.H5 E 242 G.H5.22
Van-der-waals ICL1 N 59 - G.H5 E 242 G.H5.22
Hydrophobic TM5 L 198 5x61 G.H5 L 245 G.H5.25
Polar ICL2 T 136 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 I 128 34x51 G.H5 I 235 G.H5.15
Polar TM3 R 120 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 Y 243 G.H5.23
Polar ICL2 R 134 34x57 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 134 34x57 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 P 127 34x50 G.H5 I 235 G.H5.15
Polar ICL2 P 127 34x50 G.H5 N 239 G.H5.19
Van-der-waals ICL2 P 127 34x50 G.H5 N 239 G.H5.19
Hydrophobic TM6 L 214 6x33 G.H5 L 245 G.H5.25
Van-der-waals TM6 L 214 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM6 P 210 6x29 G.H5 V 246 G.H5.26
Van-der-waals TM6 P 210 6x29 G.H5 V 246 G.H5.26
Hydrophobic TM6 R 213 6x32 G.H5 V 246 G.H5.26
Polar ICL2 R 131 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 I 128 34x51 G.H5 F 228 G.H5.08
Hydrophobic ICL2 P 127 34x50 G.H5 K 232 G.H5.12
Hydrophobic ICL2 I 128 34x51 G.H5 K 232 G.H5.12
Hydrophobic ICL2 P 127 34x50 G.H5 L 236 G.H5.16
Hydrophobic TM3 V 124 3x54 G.H5 L 236 G.H5.16
Hydrophobic TM6 I 218 6x37 G.H5 L 245 G.H5.25
Polar ICL2 C 132 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 C 132 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 C 132 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 C 132 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 C 132 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 C 132 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic TM2 V 61 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 V 61 2x39 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 Y 130 34x53 G.H5 Y 243 G.H5.23
Van-der-waals ICL2 Y 130 34x53 G.H5 Y 243 G.H5.23
Polar ICL2 R 131 34x54 G.H5 N 239 G.H5.19
Van-der-waals ICL2 R 131 34x54 G.H5 N 239 G.H5.19
Hydrophobic TM3 R 120 3x50 G.H5 L 245 G.H5.25
Hydrophobic ICL2 R 131 34x54 G.H5 M 238 G.H5.18
Van-der-waals ICL2 R 131 34x54 G.H5 M 238 G.H5.18
Hydrophobic TM3 S 123 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 S 123 3x53 G.H5 Y 243 G.H5.23
Ionic ICL2 R 131 34x54 G.H5 E 242 G.H5.22
Polar ICL2 R 131 34x54 G.H5 E 242 G.H5.22
Van-der-waals ICL2 R 131 34x54 G.H5 E 242 G.H5.22
Hydrophobic TM5 I 202 5x65 G.H5 L 240 G.H5.20