μ receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9PA2

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41594-026-01839-Y

PUBLICATION DATE

July 1, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

17 interactions (Click to see)

LIGANDS

PHENCYCLIDINE - Agonist (partial) chembl_ligand pubchem drugbank pubchem drug_central

PHYSIOLOGICAL LIGANDS

[Met]enkephalin (Human), dynorphin A-(1-8) (Human), dynorphin A (Human), dynorphin A-(1-13) (Human), β-endorphin (Mouse), endomorphin-1 (Human), β-endorphin (Rat), dynorphin B (Human), β-endorphin (Human), [Leu]enkephalin (Human), endomorphin-2 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 261 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 261 5x65 G.H5 L 348 G.H5.20
Polar TM2 T 105 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 105 2x39 G.H5 C 351 G.H5.23
Polar ICL2 R 181 34x57 G.H5 N 347 G.H5.19
Hydrophobic H8 N 344 8x49 G.H5 G 352 G.H5.24
Hydrophobic ICL3 R 265 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 265 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 V 175 34x51 G.H5 F 336 G.H5.08
Polar ICL2 R 181 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 181 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 181 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM6 N 276 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 174 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 174 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 L 261 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 178 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 178 34x54 G.S3 L 194 G.S3.01
Polar ICL2 V 175 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 175 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 174 34x50 G.H5 T 340 G.H5.12
Ionic ICL3 R 265 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 265 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 265 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 265 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 V 175 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 I 280 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 280 6x33 G.H5 L 353 G.H5.25
Polar H8 E 343 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 343 8x48 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 174 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 174 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 167 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 178 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM6 E 272 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 E 272 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 M 266 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 265 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 265 - G.S6 I 319 G.S6.01
Hydrophobic TM6 I 280 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 M 257 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 283 6x36 G.H5 L 353 G.H5.25
Hydrophobic H8 E 343 8x48 G.H5 L 353 G.H5.25
Hydrophobic H8 E 343 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 343 8x48 G.H5 F 354 G.H5.26
Polar ICL3 R 265 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 265 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 265 - G.H5 D 341 G.H5.13
Hydrophobic TM3 V 171 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 267 - G.H5 F 354 G.H5.26
Hydrophobic TM3 A 170 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 170 3x53 G.H5 C 351 G.H5.23
Polar TM3 R 167 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 167 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 175 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM2 T 105 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 105 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM5 R 260 5x64 G.H5 I 344 G.H5.16
Polar TM3 A 170 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 170 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 170 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 171 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL3 M 266 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 M 266 - G.H5 K 345 G.H5.17
Hydrophobic TM6 I 280 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL3 M 266 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 M 266 - G.H5 F 354 G.H5.26
Polar ICL3 M 266 - G.H5 D 341 G.H5.13
Hydrophobic TM5 V 264 5x68 G.H5 I 344 G.H5.16
Polar TM6 S 270 6x23 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 S 270 6x23 G.h4s6 D 315 G.h4s6.09