H4 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8HN8

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Dec. 20, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

16 interactions (Click to see)

LIGANDS

histamine - Agonist pubchem gtoplig chembl_ligand drug_central drugbank gtoplig

ENDOGENOUS LIGANDS

histamine, CCL16



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 116 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 116 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 123 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 123 34x54 G.hns1 R 32 G.hns1.03
Polar ICL2 R 123 34x54 G.S1 E 33 G.S1.01
Hydrophobic ICL2 R 123 34x54 G.S1 V 34 G.S1.02
Van-der-waals ICL2 R 123 34x54 G.S1 V 34 G.S1.02
Hydrophobic TM5 L 201 5x65 G.H5 F 354 G.H5.26
Van-der-waals TM5 L 201 5x65 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 305 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 201 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 201 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 201 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM5 R 204 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 204 5x68 G.H5 I 344 G.H5.16
Polar ICL2 H 126 - G.hns1 R 32 G.hns1.03
Polar ICL4 K 363 - G.H5 D 350 G.H5.22
Hydrophobic ICL4 K 363 - G.H5 D 350 G.H5.22
Van-der-waals ICL4 K 363 - G.H5 D 350 G.H5.22
Hydrophobic TM5 I 197 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL4 H 362 - G.H5 C 351 G.H5.23
Hydrophobic TM6 R 297 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 297 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 A 119 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 S 304 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 304 6x36 G.H5 L 353 G.H5.25
Polar ICL2 R 123 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 T 124 34x55 G.hns1 R 32 G.hns1.03
Polar ICL4 C 361 - G.H5 G 352 G.H5.24
Hydrophobic ICL4 C 361 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 C 361 - G.H5 G 352 G.H5.24
Hydrophobic TM6 K 300 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 300 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL4 H 362 - G.H5 D 350 G.H5.22
Van-der-waals ICL4 H 362 - G.H5 D 350 G.H5.22
Hydrophobic TM6 R 297 6x29 G.H5 K 345 G.H5.17
Hydrophobic ICL2 V 120 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 V 120 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL3 L 293 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 T 124 34x55 G.S3 L 194 G.S3.01
Hydrophobic TM6 L 301 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 301 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 R 123 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 R 123 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM6 L 301 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 308 6x40 G.H5 L 353 G.H5.25
Hydrophobic ICL4 C 361 - G.H5 C 351 G.H5.23
Van-der-waals ICL4 C 361 - G.H5 C 351 G.H5.23
Hydrophobic TM3 R 112 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 119 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 119 34x50 G.H5 I 344 G.H5.16