D1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

F

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7X2C

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41467-022-30929-W

PUBLICATION DATE

June 29, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

21 interactions (Click to see)

LIGANDS

fenoldopam - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem gtoplig chembl_ligand pubchem pubchem gtoplig chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

L-NOREPINEPHRINE, noradrenaline, (-)-noradrenaline, 5-hydroxytryptamine, dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 128 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM6 L 274 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 273 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 228 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 I 125 3x54 G.H5 Y 391 G.H5.23
Ionic TM5 R 227 5x71 G.H5 D 381 G.H5.13
Polar TM5 R 227 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 227 5x71 G.H5 D 381 G.H5.13
Polar TM5 Q 224 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 224 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 235 5x79 G.H4 R 347 G.H4.17
Polar TM3 S 126 3x55 G.H5 R 380 G.H5.12
Polar TM5 C 241 5x85 G.hgh4 R 317 G.hgh4.07
Hydrophobic TM5 C 241 5x85 G.hgh4 R 317 G.hgh4.07
Van-der-waals TM5 C 241 5x85 G.hgh4 R 317 G.hgh4.07
Polar TM2 T 59 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 217 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 217 5x61 G.H5 L 393 G.H5.25
Aromatic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 228 5x72 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 129 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 129 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 F 129 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM5 A 235 5x79 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM3 I 125 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 125 3x54 G.H5 H 387 G.H5.19
Polar TM5 H 237 5x81 G.hgh4 T 319 G.hgh4.09
Hydrophobic TM5 H 237 5x81 G.hgh4 T 319 G.hgh4.09
Van-der-waals TM5 H 237 5x81 G.hgh4 T 319 G.hgh4.09
Hydrophobic TM5 A 238 5x82 G.hgh4 Y 318 G.hgh4.08
Hydrophobic TM5 I 220 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 129 34x51 G.H5 I 383 G.H5.15
Polar TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 128 34x50 G.H5 R 380 G.H5.12
Polar TM5 A 238 5x82 G.H4 R 347 G.H4.17
Hydrophobic TM5 A 238 5x82 G.H4 R 347 G.H4.17
Van-der-waals TM5 A 238 5x82 G.H4 R 347 G.H4.17
Polar TM3 S 126 3x55 G.H5 Q 384 G.H5.16
Ionic ICL2 E 132 34x54 G.S1 H 41 G.S1.02
Polar ICL2 E 132 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 E 132 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 129 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM5 L 231 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM3 A 124 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 129 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 129 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 I 228 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 228 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 A 235 5x79 G.H4 L 346 G.H4.16
Hydrophobic TM5 Q 224 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Polar TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 A 221 5x65 G.H5 L 388 G.H5.20
Polar TM6 T 273 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 231 5x75 G.S6 P 361 G.S6.03
Hydrophobic TM5 K 239 5x83 G.H4 R 347 G.H4.17
Polar TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Polar TM6 V 270 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 V 270 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 270 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 V 270 6x33 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 128 34x50 G.H5 Q 384 G.H5.16
Aromatic ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 A 238 5x82 G.H4 D 343 G.H4.13
Van-der-waals TM5 A 238 5x82 G.H4 D 343 G.H4.13
Hydrophobic TM3 I 125 3x54 G.H5 L 388 G.H5.20