Structure information

D1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7X2C

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

F

REFERENCE

10.1038/S41467-022-30929-W

PUBLICATION DATE

June 29, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
fenoldopam W99 3.28x28 TM3 hydrophobic
fenoldopam D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
fenoldopam S188 45.52x52 ECL2 polar (hydrogen bond with backbone)
fenoldopam S188 45.52x52 ECL2 Van der Waals
fenoldopam S189 ECL2 polar (hydrogen bond)
fenoldopam S310 7.32x31 TM7 Van der Waals
fenoldopam F313 7.35x34 TM7 hydrophobic
fenoldopam F313 7.35x34 TM7 Van der Waals
fenoldopam D314 7.36x35 TM7 polar (charge-assisted hydrogen bond)

Ligands

fenoldopam

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Residue Diagrams

T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x28 3.28x28 W99
3x32 3.32x32 D103
ECL2
45x52 45.52x52 S188
TM7
7x31 7.32x31 S310
7x34 7.35x34 F313
7x35 7.36x35 D314