CCR2 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XA3

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41421-022-00403-4

PUBLICATION DATE

Aug. 24, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

72 interactions (Click to see)

LIGANDS

C-C motif chemokine 2 - Agonist

ENDOGENOUS LIGANDS

CCL2, CCL8, CCL11, CCL13, CCL24, CCL7, CCL26, CCL16



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM5 R 231 5x67 G.H5 D 341 G.H5.13
Polar TM5 R 231 5x67 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 231 5x67 G.H5 D 341 G.H5.13
Hydrophobic ICL2 A 145 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 A 145 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL3 R 233 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 L 229 5x65 G.H5 F 354 G.H5.26
Polar TM6 R 240 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 240 6x32 G.H5 L 353 G.H5.25
Polar H8 G 309 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 309 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 309 8x47 G.H5 G 352 G.H5.24
Polar TM6 R 240 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 240 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 240 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM2 T 77 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 142 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 I 245 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 149 34x54 G.hns1 R 32 G.hns1.03
Polar TM6 N 234 6x26 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 N 234 6x26 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM5 R 231 5x67 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 241 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 244 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 149 34x54 G.S3 L 194 G.S3.01
Polar TM2 C 75 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 C 75 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 C 75 2x37 G.H5 D 350 G.H5.22
Polar TM3 A 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 141 3x53 G.H5 N 347 G.H5.19
Ionic H8 K 311 8x49 G.H5 D 350 G.H5.22
Polar H8 K 311 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 K 311 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 311 8x49 G.H5 D 350 G.H5.22
Ionic ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 237 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 237 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 A 141 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 L 353 G.H5.25
Ionic ICL2 K 150 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 150 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 150 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 150 34x55 G.s2s3 D 193 G.s2s3.02
Ionic H8 E 310 8x48 G.H5 K 349 G.H5.21
Hydrophobic TM3 I 142 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 149 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM3 I 142 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 T 228 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 229 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 229 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 K 150 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 146 34x51 G.H5 F 336 G.H5.08
Polar H8 E 310 8x48 G.H5 F 354 G.H5.26