Refined structure (6WPW) of Gs - glucagon receptor

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 222 from structure (56.3%), 172 from model (43.7%)
Residue sidechains - 216 from structure (54.8%), 178 from model (45.2%)

REFINED GPCR RESIDUES

Residue backbones - 395 from structure (90.0%), 44 from model (10.0%)
Residue sidechains - 381 from structure (86.8%), 58 from model (13.2%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
R02G.hns1H02G.S1T03G.h4s6H19Q22G.H5GproteinH-L3x57A-R2x46L-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.S1G.h4s6G.H5GPCR segments:TM2ICL2TM3ICL3

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x392x433x493x503x533x543x555x615x645x655x685x696x326x366x396x407x568x478x48G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.18G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.08G.S6.02G.S6.01G.h4s6.20G.h4s6.03G.S3.01G.S1.02G.hns1.03G.hns1.02G.HN.52Res. Pos.glucagon (6WPW_REFINED)- (6WPW_REFINED)--------------------RHYLLLGILLKLRSTLLNKRHYLLLGILLKLRSTLLNKAQYHQLLLDREFRIMQHVCYTYRA

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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