D1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

F

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7X2F

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41467-022-30929-W

PUBLICATION DATE

June 15, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

27 interactions (Click to see)

LIGANDS

mevidalen - PAM pubchem gtoplig chembl_ligand ,

dopamine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

ENDOGENOUS LIGANDS

L-NOREPINEPHRINE, 5-hydroxytryptamine, noradrenaline, (-)-noradrenaline, dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR AA GPCR number GPCRdb# Segment G protein AA G protein number CGN# Interaction Type
R 227 5x71 TM5 D 381 G.H5.13 ionic
R 227 5x71 TM5 D 381 G.H5.13 polar
R 227 5x71 TM5 D 381 G.H5.13 hydrophobic
R 227 5x71 TM5 D 381 G.H5.13 van-der-waals
A 238 5x82 TM5 Y 318 G.hgh4.08 hydrophobic
F 129 34x51 ICL2 C 379 G.H5.11 hydrophobic
F 129 34x51 ICL2 C 379 G.H5.11 van-der-waals
A 221 5x65 TM5 L 393 G.H5.25 hydrophobic
T 59 2x39 TM2 Y 391 G.H5.23 polar
S 126 3x55 TM3 R 380 G.H5.12 polar
T 273 6x36 TM6 L 393 G.H5.25 hydrophobic
K 269 6x32 TM6 E 392 G.H5.24 polar
K 269 6x32 TM6 E 392 G.H5.24 hydrophobic
K 269 6x32 TM6 E 392 G.H5.24 van-der-waals
I 125 3x54 TM3 L 388 G.H5.20 hydrophobic
I 228 5x72 TM5 R 385 G.H5.17 hydrophobic
I 228 5x72 TM5 R 385 G.H5.17 van-der-waals
I 217 5x61 TM5 L 393 G.H5.25 hydrophobic
I 217 5x61 TM5 L 393 G.H5.25 van-der-waals
F 129 34x51 ICL2 V 217 G.S3.01 hydrophobic
I 228 5x72 TM5 Y 358 G.h4s6.20 hydrophobic
I 228 5x72 TM5 Y 358 G.h4s6.20 van-der-waals
Q 224 5x68 TM5 R 385 G.H5.17 polar
Q 224 5x68 TM5 R 385 G.H5.17 hydrophobic
Q 224 5x68 TM5 R 385 G.H5.17 van-der-waals
Q 224 5x68 TM5 Q 384 G.H5.16 polar
Q 224 5x68 TM5 Q 384 G.H5.16 van-der-waals
Y 131 34x53 ICL2 H 387 G.H5.19 hydrophobic
E 132 34x54 ICL2 R 38 G.hns1.02 polar
E 132 34x54 ICL2 R 38 G.hns1.02 van-der-waals
F 129 34x51 ICL2 R 380 G.H5.12 hydrophobic
F 129 34x51 ICL2 R 380 G.H5.12 van-der-waals
R 227 5x71 TM5 R 385 G.H5.17 hydrophobic
R 227 5x71 TM5 R 385 G.H5.17 van-der-waals
I 125 3x54 TM3 Y 391 G.H5.23 hydrophobic
I 125 3x54 TM3 Y 391 G.H5.23 van-der-waals
I 125 3x54 TM3 H 387 G.H5.19 hydrophobic
H 237 5x81 TM5 T 319 G.hgh4.09 polar
H 237 5x81 TM5 T 319 G.hgh4.09 hydrophobic
H 237 5x81 TM5 T 319 G.hgh4.09 van-der-waals
I 125 3x54 TM3 Q 384 G.H5.16 polar
I 125 3x54 TM3 Q 384 G.H5.16 hydrophobic
I 125 3x54 TM3 Q 384 G.H5.16 van-der-waals
L 274 6x37 TM6 L 393 G.H5.25 hydrophobic
I 228 5x72 TM5 L 394 G.H5.26 hydrophobic
I 228 5x72 TM5 L 394 G.H5.26 van-der-waals
K 269 6x32 TM6 L 393 G.H5.25 polar
K 269 6x32 TM6 L 393 G.H5.25 hydrophobic
K 269 6x32 TM6 L 393 G.H5.25 van-der-waals
F 129 34x51 ICL2 I 383 G.H5.15 hydrophobic
F 129 34x51 ICL2 I 383 G.H5.15 van-der-waals
T 273 6x36 TM6 E 392 G.H5.24 polar
F 129 34x51 ICL2 H 41 G.S1.02 aromatic
F 129 34x51 ICL2 H 41 G.S1.02 hydrophobic
F 129 34x51 ICL2 H 41 G.S1.02 van-der-waals
Q 224 5x68 TM5 L 388 G.H5.20 hydrophobic
Q 224 5x68 TM5 D 381 G.H5.13 polar
Q 224 5x68 TM5 D 381 G.H5.13 van-der-waals
A 235 5x79 TM5 L 346 G.H4.16 hydrophobic
L 231 5x75 TM5 R 342 G.H4.12 hydrophobic
F 129 34x51 ICL2 F 376 G.H5.08 aromatic
F 129 34x51 ICL2 F 376 G.H5.08 hydrophobic
F 129 34x51 ICL2 F 376 G.H5.08 van-der-waals
A 124 3x53 TM3 H 387 G.H5.19 polar
A 124 3x53 TM3 H 387 G.H5.19 hydrophobic
A 124 3x53 TM3 H 387 G.H5.19 van-der-waals
R 121 3x50 TM3 Y 391 G.H5.23 aromatic
R 121 3x50 TM3 Y 391 G.H5.23 hydrophobic
R 121 3x50 TM3 Y 391 G.H5.23 van-der-waals
A 235 5x79 TM5 T 350 G.h4s6.03 hydrophobic
A 235 5x79 TM5 T 350 G.h4s6.03 van-der-waals
A 124 3x53 TM3 Y 391 G.H5.23 hydrophobic
I 220 5x64 TM5 Q 384 G.H5.16 hydrophobic
K 239 5x83 TM5 R 347 G.H4.17 hydrophobic
A 238 5x82 TM5 D 343 G.H4.13 hydrophobic
A 238 5x82 TM5 D 343 G.H4.13 van-der-waals
F 129 34x51 ICL2 F 219 G.S3.03 hydrophobic
P 128 34x50 ICL2 I 383 G.H5.15 hydrophobic
P 128 34x50 ICL2 I 383 G.H5.15 van-der-waals
C 241 5x85 TM5 R 317 G.hgh4.07 polar
C 241 5x85 TM5 R 317 G.hgh4.07 hydrophobic
C 241 5x85 TM5 R 317 G.hgh4.07 van-der-waals
I 225 5x69 TM5 L 394 G.H5.26 hydrophobic
V 270 6x33 TM6 L 393 G.H5.25 hydrophobic
V 270 6x33 TM6 L 393 G.H5.25 van-der-waals
P 128 34x50 ICL2 Q 384 G.H5.16 hydrophobic
A 238 5x82 TM5 R 347 G.H4.17 polar
A 238 5x82 TM5 R 347 G.H4.17 hydrophobic
A 238 5x82 TM5 R 347 G.H4.17 van-der-waals
P 128 34x50 ICL2 R 380 G.H5.12 hydrophobic
P 128 34x50 ICL2 R 380 G.H5.12 van-der-waals
A 221 5x65 TM5 L 388 G.H5.20 hydrophobic
Q 224 5x68 TM5 L 394 G.H5.26 hydrophobic
E 132 34x54 ICL2 H 41 G.S1.02 ionic
E 132 34x54 ICL2 H 41 G.S1.02 polar
E 132 34x54 ICL2 H 41 G.S1.02 hydrophobic
E 132 34x54 ICL2 H 41 G.S1.02 van-der-waals
L 231 5x75 TM5 L 346 G.H4.16 hydrophobic
E 232 5x76 TM5 T 350 G.h4s6.03 hydrophobic
C 241 5x85 TM5 T 319 G.hgh4.09 polar
C 241 5x85 TM5 T 319 G.hgh4.09 hydrophobic
C 241 5x85 TM5 T 319 G.hgh4.09 van-der-waals
V 270 6x33 TM6 L 394 G.H5.26 hydrophobic
K 269 6x32 TM6 L 394 G.H5.26 polar
K 269 6x32 TM6 L 394 G.H5.26 hydrophobic
K 269 6x32 TM6 L 394 G.H5.26 van-der-waals