ADGRG1 - G13

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7SF8

RESOLUTION

2.7 Å

REFERENCE

10.1038/S41586-022-04575-7

PUBLICATION DATE

April 27, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Y 505 - G.HN T 28 G.HN.52
Polar ICL2 Y 505 - G.HN K 27 G.HN.51
Van-der-waals ICL2 Y 505 - G.HN K 27 G.HN.51
Hydrophobic TM5 Q 589 5x60 G.H5 L 220 G.H5.16
Van-der-waals TM5 Q 589 5x60 G.H5 L 220 G.H5.16
Hydrophobic TM7 W 651 7x56 G.H5 L 229 G.H5.25
Polar TM6 T 605 6x41 G.H5 M 228 G.H5.24
Hydrophobic TM6 T 605 6x41 G.H5 M 228 G.H5.24
Van-der-waals TM6 T 605 6x41 G.H5 M 228 G.H5.24
Hydrophobic TM5 M 586 5x57 G.H5 M 228 G.H5.24
Polar TM2 D 434 2x44 G.H5 Q 226 G.H5.22
Hydrophobic TM2 D 434 2x44 G.H5 Q 226 G.H5.22
Van-der-waals TM2 D 434 2x44 G.H5 Q 226 G.H5.22
Aromatic ICL2 Y 505 - G.hns1 K 31 G.hns1.02
Hydrophobic ICL2 Y 505 - G.hns1 K 31 G.hns1.02
Van-der-waals ICL2 Y 505 - G.hns1 K 31 G.hns1.02
Hydrophobic TM6 H 602 6x38 G.H5 M 228 G.H5.24
Van-der-waals TM6 H 602 6x38 G.H5 M 228 G.H5.24
Polar ICL3 S 601 - G.H5 Q 230 G.H5.26
Polar TM5 R 592 5x63 G.H5 H 221 G.H5.17
Aromatic TM5 R 592 5x63 G.H5 H 221 G.H5.17
Hydrophobic TM5 R 592 5x63 G.H5 H 221 G.H5.17
Van-der-waals TM5 R 592 5x63 G.H5 H 221 G.H5.17
Hydrophobic ICL2 V 501 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 V 501 - G.H5 I 219 G.H5.15
Hydrophobic TM7 M 655 7x60 G.H5 L 229 G.H5.25
Hydrophobic TM3 L 497 3x57 G.H5 Q 226 G.H5.22
Hydrophobic TM6 T 605 6x41 G.H5 Q 230 G.H5.26
Hydrophobic ICL2 F 502 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 F 502 - G.H5 I 219 G.H5.15
Hydrophobic ICL2 F 502 - G.H5 V 215 G.H5.11
Van-der-waals ICL2 F 502 - G.H5 V 215 G.H5.11
Hydrophobic ICL2 V 501 - G.H5 K 216 G.H5.12
Van-der-waals ICL2 V 501 - G.H5 K 216 G.H5.12
Hydrophobic TM5 I 590 5x61 G.H5 L 224 G.H5.20
Hydrophobic ICL2 F 502 - G.S3 V 79 G.S3.01
Hydrophobic ICL2 T 504 - G.H5 N 223 G.H5.19
Hydrophobic TM3 V 498 3x58 G.H5 L 224 G.H5.20
Hydrophobic TM5 I 590 5x61 G.H5 M 228 G.H5.24
Van-der-waals TM5 I 590 5x61 G.H5 M 228 G.H5.24
Polar TM3 L 497 3x57 G.H5 N 223 G.H5.19
Hydrophobic TM3 L 497 3x57 G.H5 N 223 G.H5.19
Van-der-waals TM3 L 497 3x57 G.H5 N 223 G.H5.19
Hydrophobic TM5 M 586 5x57 G.H5 L 227 G.H5.23
Polar ICL2 Y 505 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Y 505 - G.hns1 R 32 G.hns1.03
Aromatic ICL2 F 502 - G.H5 F 212 G.H5.08
Hydrophobic ICL2 F 502 - G.H5 F 212 G.H5.08
Van-der-waals ICL2 F 502 - G.H5 F 212 G.H5.08
Hydrophobic TM6 L 609 6x45 G.H5 L 227 G.H5.23
Polar TM2 T 436 2x46 G.H5 Q 226 G.H5.22
Van-der-waals TM2 T 436 2x46 G.H5 Q 226 G.H5.22
Ionic TM5 R 592 5x63 G.H5 D 217 G.H5.13
Hydrophobic ICL2 V 501 - G.H5 L 220 G.H5.16
Van-der-waals ICL2 V 501 - G.H5 L 220 G.H5.16
Hydrophobic TM5 M 586 5x57 G.H5 L 224 G.H5.20
Hydrophobic TM2 T 436 2x46 G.H5 L 227 G.H5.23
Hydrophobic TM3 V 498 3x58 G.H5 L 220 G.H5.16
Hydrophobic TM3 L 497 3x57 G.H5 L 227 G.H5.23
Van-der-waals TM3 L 497 3x57 G.H5 L 227 G.H5.23
Polar ICL2 V 501 - G.H5 N 223 G.H5.19
Van-der-waals ICL2 V 501 - G.H5 N 223 G.H5.19
Hydrophobic ICL2 F 502 - G.H5 K 216 G.H5.12
Van-der-waals ICL2 F 502 - G.H5 K 216 G.H5.12
Hydrophobic ICL2 P 507 - G.HN T 28 G.HN.52
Hydrophobic TM3 L 494 3x54 G.H5 L 227 G.H5.23