ADGRG6 - Gs

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

21DU

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41421-025-00866-1

PUBLICATION DATE

Feb. 11, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

8 interactions (Click to see)

LIGANDS

apomorphine - PAM pubchem gtoplig chembl_ligand drugbank drug_central pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 N 964 - G.s2s3 K 78 G.s2s3.02
Van-der-waals ICL2 N 964 - G.s2s3 K 78 G.s2s3.02
Hydrophobic ICL2 Y 966 - G.HN K 27 G.HN.51
Van-der-waals ICL2 Y 966 - G.HN K 27 G.HN.51
Hydrophobic ICL2 F 963 - G.H2 I 235 G.H2.08
Van-der-waals ICL2 F 963 - G.H2 I 235 G.H2.08
Hydrophobic TM5 V 1043 5x57 G.H5 L 240 G.H5.20
Hydrophobic TM3 L 959 3x58 G.H5 L 240 G.H5.20
Polar ICL4 E 1119 - G.H5 E 244 G.H5.24
Hydrophobic ICL2 Y 966 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 Y 966 - G.hns1 R 31 G.hns1.02
Hydrophobic TM5 I 1047 5x61 G.H5 L 240 G.H5.20
Hydrophobic TM6 S 1069 6x41 G.H5 L 245 G.H5.25
Hydrophobic ICL2 Y 966 - G.HN Q 28 G.HN.52
Van-der-waals ICL2 Y 966 - G.HN Q 28 G.HN.52
Hydrophobic TM6 L 1076 6x48 G.H5 Y 243 G.H5.23
Polar TM6 R 1068 6x40 G.H5 E 244 G.H5.24
Hydrophobic TM5 R 1050 5x64 G.H5 L 246 G.H5.26
Van-der-waals TM5 R 1050 5x64 G.H5 L 246 G.H5.26
Hydrophobic ICL2 V 962 - G.H5 R 232 G.H5.12
Hydrophobic TM5 I 1047 5x61 G.H5 L 245 G.H5.25
Van-der-waals TM5 I 1047 5x61 G.H5 L 245 G.H5.25
Ionic ICL4 K 1118 - G.H5 E 244 G.H5.24
Polar ICL4 K 1118 - G.H5 E 244 G.H5.24
Hydrophobic ICL4 K 1118 - G.H5 E 244 G.H5.24
Van-der-waals ICL4 K 1118 - G.H5 E 244 G.H5.24
Hydrophobic TM5 I 1047 5x61 G.H5 L 246 G.H5.26
Polar TM6 R 1065 6x37 G.H5 E 244 G.H5.24
Hydrophobic TM3 L 959 3x58 G.H5 H 239 G.H5.19
Van-der-waals TM3 L 959 3x58 G.H5 H 239 G.H5.19
Aromatic ICL2 F 963 - G.H5 F 228 G.H5.08
Hydrophobic ICL2 F 963 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 F 963 - G.H5 F 228 G.H5.08
Hydrophobic TM5 V 1043 5x57 G.H5 L 245 G.H5.25
Van-der-waals TM5 V 1043 5x57 G.H5 L 245 G.H5.25
Hydrophobic TM3 M 955 3x54 G.H5 Y 243 G.H5.23
Polar TM3 E 951 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 E 951 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 E 951 3x50 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 F 963 - G.H5 C 231 G.H5.11
Hydrophobic TM5 Q 1046 5x60 G.H5 Q 236 G.H5.16
Hydrophobic TM2 P 897 2x46 G.H5 Q 242 G.H5.22
Van-der-waals TM2 P 897 2x46 G.H5 Q 242 G.H5.22
Polar TM3 A 958 3x57 G.H5 H 239 G.H5.19
Hydrophobic TM3 A 958 3x57 G.H5 H 239 G.H5.19
Van-der-waals TM3 A 958 3x57 G.H5 H 239 G.H5.19
Aromatic ICL2 F 963 - G.S1 H 34 G.S1.02
Hydrophobic ICL2 F 963 - G.S1 H 34 G.S1.02
Van-der-waals ICL2 F 963 - G.S1 H 34 G.S1.02
Hydrophobic TM5 R 1050 5x64 G.H5 L 240 G.H5.20
Hydrophobic TM6 L 1073 6x45 G.H5 L 245 G.H5.25
Hydrophobic TM5 R 1050 5x64 G.H5 R 237 G.H5.17
Hydrophobic ICL2 F 963 - G.H5 R 232 G.H5.12
Van-der-waals ICL2 F 963 - G.H5 R 232 G.H5.12
Van-der-waals ICL4 M 1117 - G.H5 E 244 G.H5.24
Polar TM3 L 959 3x58 G.H5 Q 236 G.H5.16
Hydrophobic TM3 L 959 3x58 G.H5 Q 236 G.H5.16
Van-der-waals TM3 L 959 3x58 G.H5 Q 236 G.H5.16
Ionic TM5 R 1050 5x64 G.H5 D 233 G.H5.13
Polar TM5 R 1050 5x64 G.H5 D 233 G.H5.13
Hydrophobic TM5 R 1050 5x64 G.H5 D 233 G.H5.13
Van-der-waals TM5 R 1050 5x64 G.H5 D 233 G.H5.13
Hydrophobic TM3 H 954 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 H 954 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM2 P 897 2x46 G.H5 Y 243 G.H5.23
Van-der-waals TM2 P 897 2x46 G.H5 Y 243 G.H5.23
Polar ICL2 Y 966 - G.HN Q 24 G.HN.48
Van-der-waals ICL2 Y 966 - G.HN Q 24 G.HN.48
Hydrophobic ICL2 F 963 - G.S3 V 79 G.S3.01
Van-der-waals ICL2 F 963 - G.S3 V 79 G.S3.01
Polar TM3 V 960 3x59 G.H5 R 232 G.H5.12
Van-der-waals TM3 V 960 3x59 G.H5 R 232 G.H5.12
Hydrophobic ICL2 V 962 - G.H5 Q 236 G.H5.16
Van-der-waals ICL2 V 962 - G.H5 Q 236 G.H5.16
Hydrophobic ICL2 F 963 - G.S3 F 81 G.S3.03
Hydrophobic ICL2 V 962 - G.H2 I 235 G.H2.08
Van-der-waals ICL2 V 962 - G.H2 I 235 G.H2.08
Hydrophobic ICL2 R 968 - G.HN Q 24 G.HN.48
Van-der-waals ICL2 R 968 - G.HN Q 24 G.HN.48
Polar TM5 R 1050 5x64 G.H5 Q 236 G.H5.16
Hydrophobic TM5 R 1050 5x64 G.H5 Q 236 G.H5.16
Van-der-waals TM5 R 1050 5x64 G.H5 Q 236 G.H5.16