PDB
21DU
Resolution
2.9 Å
Released
Feb. 11, 2026
Receptor
ADGRG6
Class
B2
Species
Homo sapiens
Ligand
apomorphine
Function
PAM
Reference
10.1038/S41421-025-00866-1

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Ligand Amino Acid Generic Number Segment Interaction Type
apomorphine F910 2.59x59 TM2 hydrophobic
apomorphine W979 4.50x50 TM4 aromatic (face-to-face)

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ICL1 E K L R R ICL1ECL1 N ECL1ICL2 V F N T Y I R ICL2ECL2 N N N E V Y G K E S Y G K E K G D E F C W I Q D ECL2ICL3 S N R T L R E ICL3ECL3 P L N ECL3N-term M M F R S D R M W S C H W K W K P S P L L F L F A L Y I M C V P H S V W G C A N C R V V L S N P S G T F T S P C Y P N D Y P N S Q A C M W T L R A P T G Y I I Q I T F N D F D I E E A P N C I Y D S L S L D N G E S Q T K F C G A T A K G L S F N S S A N E M H V S F S S D F S I Q K K G F N A S Y I R V A V S L R N Q K V I L P Q T S D A Y Q V S V A K S I S I P E L S A F T L C F E A T K V G H E D S D W T A F S Y S N A S F T Q L L S F G K A K S G Y F L S I S D S K C L L N N A L P V K E K E D I F A E S F E Q L C L V W N N S L G S I G V N F K R N Y E T V P C D S T I S K V I P G N G K L L L G S N Q N E I V S L K G D I Y N F R L W N F T M N A K I L S N L S C N V K G N V V D W Q N D F W N I P N L A L K A E S N L S C G S Y L I P L P A A E L A S C A D L G T L C Q A T V N S P S T T P P T V T T N M P V T N R I D K Q R N D G I I Y R I S V V I Q N I L R H P E V K V Q S K V A E W L N S T F Q N W N Y T V Y V V N I S F H L S A G E D K I K V K R S L E D E P R L V L W A L L V Y N A T N N T N L E G K I I Q Q K L L K N N E S L D E G L R L H T V N V R Q L G H C L A M E E P K G Y Y W P S I Q P S E Y V L P C P D K P G F S A S R I C F Y N A T N P L V T Y W G P V D I S N C L K E N-termC-term R L A D N S D W S K T A T N I I K K S S D N L G K S L S S S S I G S N S T Y L T S K S K S S S T T Y F K R N S H T D N V S Y E H S F N K S G S L R Q C F H G Q V L V K T G P C C-term A R N T K V L T F I S Y I G C G I S A I F S A A T L L T Y V A F D Y P S K I L M N L S T A L L F L N L L F L L D G W I T S F V D G L C I A V A V L L H F F L L A T F T W M G L E A I H M Y I A L V K R Y I L K F C I I G W G L P A L V V S V V L A S R P V I F Y V T C A G Y F G V M F F L N I A M F I V V M V Q I C G R N G K R E V L R N L R S V V S L T F L L G M T W G F A F F A W G I P F M Y L F S I F N S L Q G L F I F I F H C A M K E N W R Q G R F V Q K Q H L C C
Helix box plot — Download: PNG | SVG A S F I A S I G C G I Y S I F T L V K T 1 M N L S T A L L F L N L L F L L D G W I 2 L G M W T F T A L L F F H L L V A V A I 3 Y I L K F C I G I W G L P A L V V S V V L 4 F M A I N L F F M V G F Y G A C T V Y F I 5 V S L T F L L G M T W G F A F F A W G 6 I F I F L G Q L S N F I S F L Y M F P 7

GPCRdb(A)
GPCRdb(B)
ADGRG6
TM2
2x52 2.59x59 F910
TM4
4x50 4.50x50 W979