GPCRdb

chlorpromazine

Agent/drug
Bioactivity

chlorpromazine

SMILES	CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21
InChIKey	ZPEIMTDSQAKGNT-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	318.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	α_2A D₁ D₂ D₃ D₅

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	8.46	8.46	8.46	ChEMBL
α_1A	Q9TSW7	Pig	Adrenoceptors	A	pKi	6.80	7.45	8.10	PDSP Ki database
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.02	8.02	8.02	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	9.09	9.09	9.09	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.04	8.04	8.04	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.08	8.08	8.08	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.30	8.30	8.30	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.71	8.71	8.71	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	9.55	9.55	9.55	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.06	8.06	8.06	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.50	6.05	6.60	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.88	6.88	6.88	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.25	6.67	7.11	PDSP Ki database
α_2A	ADA2A	Pig	Adrenoceptors	A	pKi	7.19	7.19	7.19	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.60	7.45	8.30	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.92	7.92	7.92	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.55	7.81	8.32	PDSP Ki database
α_2B	ADA2B	Rat	Adrenoceptors	A	pKi	7.60	7.63	7.66	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central

Showing 1 to 20 of 161 entries

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Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.07	8.07	8.07	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.09	8.09	8.09	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	8.05	8.05	8.05	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	8.40	8.40	8.40	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.45	6.45	6.45	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.58	7.58	7.58	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.43	6.43	6.43	ChEMBL
δ	OPRD	Human	Opioid	A	pIC50	4.68	4.68	4.68	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	4.96	4.96	4.96	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	4.84	4.84	4.84	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.33	5.88	6.43	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	5.39	5.39	5.39	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	8.41	8.44	8.47	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.90	6.90	6.90	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	8.28	8.28	8.28	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	7.24	7.24	7.24	ChEMBL
D₁	DRD1	Rat	Dopamine	A	pIC50	8.67	8.67	8.67	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	6.65	6.65	6.65	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	7.40	7.40	7.40	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	7.27	8.34	9.00	ChEMBL

Showing 1 to 20 of 37 entries

chlorpromazine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 9

Phase II 18

Phase III 18

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	α_2A D₁ D₂ D₃ D₅

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	COVID-19	RA01	N05A	0.001	3	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Conduct-dissocial disorder, unspecified	6C91.Z	N05A	0.370	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Glioblastoma of brain	2A00.00	N05A	0.251	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90	N05A	0.306	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Other specified mental, behavioural or neurodevelopmental disorders	6E8Y	N05A	0.550	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.566	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.622	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	COVID-19	RA01	N05A	0.269	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Conduct-dissocial disorder, unspecified	6C91.Z	N05A	0.530	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Delirium, unspecified or unknown cause	6D70.Z	N05A	0.588	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Glioblastoma of brain	2A00.00	N05A	0.283	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Malignant neoplasms of colon, unspecified	2B90.Z	N05A	0.037	1	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90	N05A	0.543	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Neonatal withdrawal syndrome from maternal use of drugs of addiction	KD35	N05A	0.259	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Other specified mental, behavioural or neurodevelopmental disorders	6E8Y	N05A	0.601	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Porphyrias, unspecified	5C58.1Z	N05A	0.370	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.609	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.620	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	COVID-19	RA01	N05A	0.343	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Glioblastoma of brain	2A00.00	N05A	0.023	2	Yes

Showing 1 to 20 of 69 entries

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chlorpromazine

chlorpromazine

Chemical Properties

Database connections

Bioactivities

chlorpromazine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information