ADGRL3 - Gs

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7WY8

RESOLUTION

2.8 Å

REFERENCE

10.1016/J.MOLCEL.2022.10.009

PUBLICATION DATE

Oct. 26, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 V 1038 3x59 G.H5 R 380 G.H5.12
Hydrophobic TM3 L 1037 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 1041 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 1041 - G.H5 F 376 G.H5.08
Hydrophobic TM3 L 1033 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 1033 3x54 G.H5 Y 391 G.H5.23
Ionic ICL2 E 1042 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 E 1044 - G.hns1 A 39 G.hns1.03
Polar H8 K 1197 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 K 1197 8x49 G.H5 Q 390 G.H5.22
Hydrophobic TM3 M 1036 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 M 1036 3x57 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 1041 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 1041 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 1041 - G.S1 H 41 G.S1.02
Polar TM2 R 977 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 977 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 977 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 1040 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 1041 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 1041 - G.H5 R 380 G.H5.12
Hydrophobic TM5 K 1113 5x60 G.H5 L 388 G.H5.20
Polar TM3 L 1037 3x58 G.H5 Q 384 G.H5.16
Polar ICL3 H 1117 - G.H5 R 385 G.H5.17
Ionic H8 K 1196 8x48 G.H5 E 392 G.H5.24
Polar H8 K 1196 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 1196 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 1196 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 S 1043 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 F 1041 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 V 1040 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 1040 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 1041 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 1041 - G.H5 I 383 G.H5.15
Polar TM3 Q 1032 3x53 G.H5 Y 391 G.H5.23
Polar TM3 M 1036 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 M 1036 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 M 1036 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 1037 3x58 G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 1040 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 1040 - G.H5 I 383 G.H5.15