C3a receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

E

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9L0H

RESOLUTION

3.6 Å

REFERENCE

PUBLICATION DATE

Nov. 26, 2025

3D VIEW

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LIGAND INTERACTIONS

18 interactions (Click to see)

LIGANDS

JR14a - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 Q 131 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 I 128 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 I 128 - G.S3 L 195 G.S3.01
Polar ICL2 N 132 - G.s2s3 N 194 G.s2s3.02
Polar ICL2 N 132 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 N 132 - G.hns1 K 32 G.hns1.03
Hydrophobic TM3 I 123 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM4 R 137 4x40 G.HN I 28 G.HN.52
Van-der-waals TM4 R 137 4x40 G.HN I 28 G.HN.52
Hydrophobic ICL2 Q 131 - G.H5 I 343 G.H5.15
Hydrophobic TM3 R 120 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 120 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM7 L 431 7x56 G.H5 G 352 G.H5.24
Polar TM6 T 368 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 368 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 368 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 356 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 V 124 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 124 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 Y 349 5x58 G.H5 L 353 G.H5.25
Van-der-waals TM5 Y 349 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM2 N 57 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 123 3x53 G.H5 C 351 G.H5.23
Polar TM6 K 367 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 367 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 367 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 367 6x32 G.H5 L 353 G.H5.25
Polar ICL3 N 360 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 N 360 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 Q 131 - G.S3 L 195 G.S3.01
Hydrophobic TM3 I 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 127 - G.H5 I 344 G.H5.16
Polar ICL3 K 363 - G.h4s6 P 315 G.h4s6.09
Hydrophobic ICL3 K 363 - G.h4s6 P 315 G.h4s6.09
Van-der-waals ICL3 K 363 - G.h4s6 P 315 G.h4s6.09
Polar TM2 N 57 2x39 G.H5 G 350 G.H5.22
Hydrophobic ICL3 F 361 - G.H5 Y 354 G.H5.26
Hydrophobic ICL3 S 364 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 S 364 - G.H5 Y 354 G.H5.26
Polar TM6 K 367 6x32 G.H5 G 352 G.H5.24
Hydrophobic ICL2 I 128 - G.H5 F 336 G.H5.08