A2A receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

4.1 Å

REFERENCE

PUBLICATION DATE

May 16, 2018

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

adenosine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Aromatic TM3 R 102 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 102 3x50 G.H5 Y 381 G.H5.23
Van-der-waals TM3 R 102 3x50 G.H5 Y 381 G.H5.23
Polar TM3 I 106 3x54 G.H5 Q 374 G.H5.16
Hydrophobic TM3 I 106 3x54 G.H5 Q 374 G.H5.16
Van-der-waals TM3 I 106 3x54 G.H5 Q 374 G.H5.16
Hydrophobic TM5 I 200 5x61 G.H5 L 383 G.H5.25
Van-der-waals TM5 I 200 5x61 G.H5 L 383 G.H5.25
Hydrophobic ICL2 P 109 34x50 G.H5 R 370 G.H5.12
Hydrophobic ICL2 P 109 34x50 G.H5 Q 374 G.H5.16
Van-der-waals ICL2 P 109 34x50 G.H5 Q 374 G.H5.16
Hydrophobic TM6 S 234 6x36 G.H5 L 383 G.H5.25
Van-der-waals TM6 S 234 6x36 G.H5 L 383 G.H5.25
Hydrophobic TM5 A 204 5x65 G.H5 L 378 G.H5.20
Hydrophobic TM6 A 231 6x33 G.H5 L 383 G.H5.25
Van-der-waals TM6 A 231 6x33 G.H5 L 383 G.H5.25
Hydrophobic ICL2 L 110 34x51 G.H5 C 369 G.H5.11
Polar TM6 S 234 6x36 G.H5 E 382 G.H5.24
Hydrophobic ICL2 L 110 34x51 G.H5 I 373 G.H5.15
Hydrophobic TM5 A 203 5x64 G.H5 L 378 G.H5.20
Hydrophobic ICL2 G 114 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM3 I 106 3x54 G.H5 L 378 G.H5.20
Van-der-waals TM3 I 106 3x54 G.H5 L 378 G.H5.20
Hydrophobic ICL2 L 110 34x51 G.S3 V 217 G.S3.01
Van-der-waals TM3 R 107 3x55 G.H5 R 370 G.H5.12
Hydrophobic TM5 Q 207 5x68 G.H5 L 384 G.H5.26
Hydrophobic TM6 L 235 6x37 G.H5 L 383 G.H5.25
Van-der-waals TM6 L 235 6x37 G.H5 L 383 G.H5.25
Hydrophobic ICL2 L 110 34x51 G.H5 R 370 G.H5.12
Hydrophobic TM3 I 106 3x54 G.H5 H 377 G.H5.19
Van-der-waals TM3 I 106 3x54 G.H5 H 377 G.H5.19
Hydrophobic TM5 L 208 5x69 G.H5 L 384 G.H5.26
Polar TM7 R 291 7x56 G.H5 E 382 G.H5.24
Van-der-waals TM7 R 291 7x56 G.H5 E 382 G.H5.24
Polar TM3 A 105 3x53 G.H5 H 377 G.H5.19
Hydrophobic TM3 A 105 3x53 G.H5 H 377 G.H5.19
Van-der-waals TM3 A 105 3x53 G.H5 H 377 G.H5.19
Hydrophobic ICL2 R 111 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 111 34x52 G.S3 V 217 G.S3.01
Polar ICL2 L 110 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 110 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 110 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 Q 207 5x68 G.H5 L 378 G.H5.20
Polar H8 R 293 8x48 G.H5 Q 380 G.H5.22
Hydrophobic ICL2 R 111 34x52 G.s2s3 K 216 G.s2s3.02
Polar ICL2 N 113 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 N 113 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 N 113 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 110 34x51 G.H5 F 366 G.H5.08
Van-der-waals ICL2 L 110 34x51 G.H5 F 366 G.H5.08
Hydrophobic TM3 I 106 3x54 G.H5 Y 381 G.H5.23
Polar TM5 Q 207 5x68 G.H5 Q 374 G.H5.16
Hydrophobic TM5 Q 207 5x68 G.H5 Q 374 G.H5.16
Van-der-waals TM5 Q 207 5x68 G.H5 Q 374 G.H5.16
Aromatic ICL2 Y 112 34x53 G.H5 H 377 G.H5.19
Hydrophobic ICL2 Y 112 34x53 G.H5 H 377 G.H5.19
Hydrophobic ICL3 M 211 - G.h4s6 Y 348 G.h4s6.20
Hydrophobic ICL2 P 109 34x50 G.H5 I 373 G.H5.15
Van-der-waals ICL2 P 109 34x50 G.H5 I 373 G.H5.15
Hydrophobic ICL2 N 113 34x54 G.hns1 A 39 G.hns1.03
Polar TM5 Q 207 5x68 G.H5 D 371 G.H5.13
Hydrophobic TM5 Q 207 5x68 G.H5 D 371 G.H5.13
Van-der-waals TM5 Q 207 5x68 G.H5 D 371 G.H5.13
Polar H8 R 293 8x48 G.H5 E 382 G.H5.24
Hydrophobic H8 R 293 8x48 G.H5 E 382 G.H5.24
Van-der-waals H8 R 293 8x48 G.H5 E 382 G.H5.24