CB1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Feb. 12, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

AM841 - Agonist pubchem gtoplig chembl_ligand

ENDOGENOUS LIGANDS

2-arachidonoylglycerol, anandamide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar ICL2 Y 224 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 224 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 224 34x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 218 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 M 337 6x29 G.H5 L 348 G.H5.20
Van-der-waals TM6 M 337 6x29 G.H5 L 348 G.H5.20
Polar TM3 D 213 3x49 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 222 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 222 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 M 337 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 M 337 6x29 G.H5 K 345 G.H5.17
Hydrophobic ICL2 Y 224 34x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 214 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 214 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM2 R 150 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM6 E 340 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 E 340 6x32 G.H5 F 354 G.H5.26
Polar TM2 R 150 2x37 G.H5 K 349 G.H5.21
Hydrophobic TM6 L 341 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 H 304 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 304 5x68 G.H5 I 344 G.H5.16
Polar TM2 S 152 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 341 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 341 6x33 G.H5 L 348 G.H5.20
Polar TM3 S 217 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 217 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 S 217 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 341 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 297 5x61 G.H5 L 353 G.H5.25
Polar TM3 R 214 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 214 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 214 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 222 34x51 G.H5 I 343 G.H5.15
Ionic TM5 R 311 5x75 G.H5 D 337 G.H5.09
Polar TM5 R 311 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 311 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM5 M 308 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 M 308 5x72 G.H5 D 341 G.H5.13
Polar ICL3 T 313 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 T 313 - G.S6 T 321 G.S6.03
Hydrophobic TM5 Y 294 5x58 G.H5 L 353 G.H5.25
Polar ICL2 P 221 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 221 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM5 M 308 5x72 G.S6 Y 320 G.S6.02
Polar TM3 S 217 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 217 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 221 34x50 G.H5 I 343 G.H5.15
Ionic TM5 H 304 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 304 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 304 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 304 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 Y 224 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 224 34x53 G.H5 N 347 G.H5.19
Ionic ICL2 R 226 34x55 G.HN E 28 G.HN.52
Polar ICL2 R 226 34x55 G.HN E 28 G.HN.52
Hydrophobic TM5 H 304 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM6 M 337 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 M 337 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 221 34x50 G.H5 I 344 G.H5.16