Structure information

CB1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6KPG

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2020.01.008

PUBLICATION DATE

Feb. 12, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AM841 F108 N-term hydrophobic
AM841 F170 2.57x57 TM2 aromatic (edge-to-face)
AM841 F174 2.61x61 TM2 hydrophobic
AM841 F177 2.64x64 TM2 hydrophobic
AM841 H178 2.65x65 TM2 Van der Waals
AM841 H178 2.65x65 TM2 polar (hydrogen bond)
AM841 F189 3.25x25 TM3 hydrophobic
AM841 L193 3.29x29 TM3 Van der Waals
AM841 L193 3.29x29 TM3 hydrophobic
AM841 V196 3.32x32 TM3 Van der Waals
AM841 T197 3.33x33 TM3 Van der Waals
AM841 F200 3.36x36 TM3 Van der Waals
AM841 P251 4.60x60 TM4 Van der Waals
AM841 F268 ECL2 Van der Waals
AM841 F268 ECL2 aromatic (edge-to-face)
AM841 I271 ECL2 hydrophobic
AM841 I271 ECL2 Van der Waals
AM841 Y275 5.39x39 TM5 hydrophobic
AM841 Y275 5.39x39 TM5 Van der Waals
AM841 L276 5.40x40 TM5 Van der Waals
AM841 W279 5.43x43 TM5 hydrophobic
AM841 W279 5.43x43 TM5 Van der Waals
AM841 L359 6.51x51 TM6 hydrophobic
AM841 L359 6.51x51 TM6 Van der Waals
AM841 F379 7.35x34 TM7 Van der Waals
AM841 F379 7.35x34 TM7 hydrophobic
AM841 S383 7.39x38 TM7 Van der Waals
AM841 C386 7.42x41 TM7 Van der Waals

Ligands

AM841

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Residue Diagrams

L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7
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ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x57 2.57x57 F170
2x61 2.61x61 F174
2x64 2.64x64 F177
2x65 2.65x65 H178
TM3
3x25 3.25x25 F189
3x29 3.29x29 L193
3x32 3.32x32 V196
3x33 3.33x33 T197
3x36 3.36x36 F200
TM4
4x60 4.60x60 P251
TM5
5x39 5.39x39 Y275
5x40 5.40x40 L276
5x43 5.43x43 W279
TM6
6x51 6.51x51 L359
TM7
7x34 7.35x34 F379
7x38 7.39x38 S383
7x41 7.42x41 C386