5-HT1F receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

April 8, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

LY334370 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM5 A 208 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 129 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 V 129 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM3 I 125 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 125 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 125 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 125 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 I 204 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM5 A 208 5x65 G.H5 L 353 G.H5.25
Polar TM6 T 294 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 T 294 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL2 V 129 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 L 295 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 211 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 L 211 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 128 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 128 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 A 291 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 291 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 125 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 211 5x68 G.H5 D 341 G.H5.13
Polar TM3 A 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic H8 N 351 8x47 G.H5 G 350 G.H5.22
Van-der-waals H8 N 351 8x47 G.H5 G 350 G.H5.22
Hydrophobic ICL2 V 129 34x51 G.S3 L 195 G.S3.01
Aromatic TM6 R 287 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 287 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 287 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM3 I 125 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL4 F 350 - G.H5 G 352 G.H5.24
Polar ICL2 R 133 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 R 133 34x55 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 R 133 34x55 G.s2s3 N 194 G.s2s3.02
Polar ICL2 E 130 34x52 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 E 130 34x52 G.s2s3 N 194 G.s2s3.02
Hydrophobic TM5 I 204 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 204 5x61 G.H5 L 353 G.H5.25
Polar TM5 L 211 5x68 G.H5 Y 354 G.H5.26
Van-der-waals TM5 L 211 5x68 G.H5 Y 354 G.H5.26
Polar TM6 R 287 6x29 G.h4s6 N 316 G.h4s6.10
Van-der-waals TM6 R 287 6x29 G.h4s6 N 316 G.h4s6.10
Polar TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 128 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 128 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 129 34x51 G.H5 I 343 G.H5.15