PDB
21AG
Resolution
3.1 Å
Released
April 8, 2026
Receptor
5-HT1F
Class
A
Species
Homo sapiens
Ligand
LY334370
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
LY334370 D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
LY334370 I104 3.33x33 TM3 hydrophobic
LY334370 I104 3.33x33 TM3 Van der Waals
LY334370 C107 3.36x36 TM3 Van der Waals
LY334370 T108 3.37x37 TM3 Van der Waals
LY334370 T108 3.37x37 TM3 polar (hydrogen bond)
LY334370 I174 45.52x52 ECL2 polar (hydrogen bond with backbone)
LY334370 I174 45.52x52 ECL2 Van der Waals
LY334370 K175 ECL2 Van der Waals
LY334370 H176 ECL2 polar (hydrogen bond with backbone)
LY334370 H176 ECL2 Van der Waals
LY334370 T182 5.39x40 TM5 Van der Waals
LY334370 S185 5.42x43 TM5 Van der Waals
LY334370 A189 5.46x461 TM5 Van der Waals
LY334370 W306 6.48x48 TM6 Van der Waals
LY334370 W306 6.48x48 TM6 hydrophobic
LY334370 F309 6.51x51 TM6 hydrophobic
LY334370 F309 6.51x51 TM6 Van der Waals
LY334370 F310 6.52x52 TM6 aromatic (edge-to-face)
LY334370 F310 6.52x52 TM6 Van der Waals
LY334370 N317 6.59x59 TM6 Van der Waals
LY334370 N317 6.59x59 TM6 polar (hydrogen bond)
LY334370 A333 7.39x38 TM7 Van der Waals
LY334370 A333 7.39x38 TM7 hydrophobic
LY334370 Y337 7.43x42 TM7 Van der Waals
LY334370 Y337 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R K L H ICL1ECL1 S W I M ECL1ICL2 A V E Y A R K R ICL2ECL2 Q G T S R D D E C I I K H D ECL2ICL3 I A K E E V N G Q V L L E S G E K S T K S V S T S Y V L E K S L S D P S T D F D K I H S T V R S L R S E F K H E K S W R R Q ICL3ECL3 D K C K I ECL3N-term M D F L N S S D Q N L T S E E L L N R N-termC-term V R C R C C-term M P S K I L V S L T L S G L A L M T T T I N S L V I A A I I V T H P A N Y L I C S L A V T D F L V A V L V M P F S I V Y I V R E G Q V V C D I W L S V D I T C C T C S I L H L S A I A L D R Y R A I T D T P K H A G I M I T I V W I I S V F I S M P P L F W R H H I V S T I Y S T F G A F Y I P L A L I L I L Y Y K I Y R A A K T L Y H K R Q A S R K I S G T R E R K A A T T L G L I L G A F V I C W L P F F V K E L V V N V C S E E M S N F L A W L G Y L N S L I N P L I Y T I F N E D F Q K F K K A L
Helix box plot — Download: PNG | SVG S N I T T T M L A L G S L T L S V L I K 1 C S L A V T D F L V A L V V M P F S I V Y 2 A S L H L I S C T C C T I D V S L W I D 3 A G I M I T I V W I I S V F I S M P P L 4 Y L I L I L A L P I Y F A G F T S Y I T S 5 G L I L G A F V I C W L P F F V K E L V 6 L P N I L S N L Y G L W A L F N S M E 7

GPCRdb(A)
GPCRdb(A)
5-HT1F receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 C107
3x37 3.37x37 T108
ECL2
45x52 45.52x52 I174
TM5
5x40 5.39x40 T182
5x43 5.42x43 S185
5x461 5.46x461 A189
TM6
6x48 6.48x48 W306
6x51 6.51x51 F309
6x52 6.52x52 F310
6x59 6.59x59 N317
TM7
7x38 7.39x38 A333
7x42 7.43x42 Y337