NMU2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XK8

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41467-022-34814-4

PUBLICATION DATE

Feb. 22, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

66 interactions (Click to see)

LIGANDS

Neuromedin U-25 (human) - Agonist pubchem

PHYSIOLOGICAL LIGANDS

neuromedin U-25, neuromedin S-36, neuromedin S-33, neuromedin U-23



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 T 78 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 78 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 78 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM6 V 266 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 266 6x33 G.H5 L 353 G.H5.25
Van-der-waals C-term S 331 - G.H5 G 352 G.H5.24
Polar C-term S 331 - G.H5 F 354 G.H5.26
Polar TM3 E 143 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 E 143 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 80 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 80 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 156 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 L 156 34x55 G.HN E 28 G.HN.52
Hydrophobic TM3 A 147 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 147 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 151 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 151 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 F 152 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 152 34x51 G.S3 L 194 G.S3.01
Polar C-term R 333 - G.H5 K 349 G.H5.21
Van-der-waals C-term R 333 - G.H5 K 349 G.H5.21
Hydrophobic ICL2 L 156 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 L 156 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 M 239 5x61 G.H5 L 353 G.H5.25
Polar TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 347 G.H5.19
Polar TM2 T 80 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 80 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 80 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM3 I 148 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 148 3x54 G.H5 L 348 G.H5.20
Hydrophobic C-term L 330 - G.H5 L 353 G.H5.25
Van-der-waals C-term L 330 - G.H5 L 353 G.H5.25
Hydrophobic C-term L 330 - G.H5 F 354 G.H5.26
Van-der-waals C-term L 330 - G.H5 F 354 G.H5.26
Hydrophobic TM3 I 148 3x54 G.H5 I 344 G.H5.16
Hydrophobic C-term L 330 - G.H5 G 352 G.H5.24
Van-der-waals C-term L 330 - G.H5 G 352 G.H5.24
Hydrophobic TM5 L 243 5x65 G.H5 L 348 G.H5.20
Polar TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 151 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 F 152 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 152 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 C 262 6x29 G.H5 F 354 G.H5.26
Polar TM3 I 148 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 151 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 R 263 6x30 G.H5 I 344 G.H5.16