Structure information

NMU2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XK8

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-34814-4

PUBLICATION DATE

Feb. 22, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Neuromedin U-25 (human) E102 2.61x60 TM2 polar (charge-assisted hydrogen bond)
Neuromedin U-25 (human) E105 2.64x63 TM2 polar (charge-assisted hydrogen bond)
Neuromedin U-25 (human) M106 2.65x64 TM2 hydrophobic
Neuromedin U-25 (human) M106 2.65x64 TM2 Van der Waals
Neuromedin U-25 (human) N109 ECL1 polar (hydrogen bond)
Neuromedin U-25 (human) N109 ECL1 Van der Waals
Neuromedin U-25 (human) N109 ECL1 polar (hydrogen bond)
Neuromedin U-25 (human) F126 3.32x32 TM3 hydrophobic
Neuromedin U-25 (human) F126 3.32x32 TM3 Van der Waals
Neuromedin U-25 (human) E127 3.33x33 TM3 polar (charge-assisted hydrogen bond)
Neuromedin U-25 (human) H185 ECL2 polar (hydrogen bond)
Neuromedin U-25 (human) P199 ECL2 Van der Waals
Neuromedin U-25 (human) P199 ECL2 polar (hydrogen bond with backbone)
Neuromedin U-25 (human) S201 ECL2 Van der Waals
Neuromedin U-25 (human) C204 45.50x50 ECL2 Van der Waals
Neuromedin U-25 (human) Y213 5.35x35 TM5 Van der Waals
Neuromedin U-25 (human) Y213 5.35x35 TM5 polar (hydrogen bond)
Neuromedin U-25 (human) F284 6.51x51 TM6 hydrophobic
Neuromedin U-25 (human) F284 6.51x51 TM6 Van der Waals
Neuromedin U-25 (human) R288 6.55x55 TM6 polar (charge-assisted hydrogen bond)
Neuromedin U-25 (human) F291 6.58x58 TM6 hydrophobic
Neuromedin U-25 (human) F291 6.58x58 TM6 Van der Waals
Neuromedin U-25 (human) W297 ECL3 hydrophobic
Neuromedin U-25 (human) W297 ECL3 Van der Waals
Neuromedin U-25 (human) A302 7.28x27 TM7 Van der Waals
Neuromedin U-25 (human) A302 7.28x27 TM7 hydrophobic
Neuromedin U-25 (human) F305 7.31x30 TM7 Van der Waals
Neuromedin U-25 (human) F305 7.31x30 TM7 hydrophobic
Neuromedin U-25 (human) N306 7.32x31 TM7 Van der Waals
Neuromedin U-25 (human) H309 7.35x34 TM7 polar (hydrogen bond)
Neuromedin U-25 (human) H309 7.35x34 TM7 Van der Waals
Neuromedin U-25 (human) G313 7.39x38 TM7 Van der Waals

Ligands

Neuromedin U-25 (human)

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Residue Diagrams

V N G I V G V V F I P V Y V V S V P L F 1 F S L A V S D L L V L L L G M P L E V Y E 2 T T I S L I S A F C V T E F L A T K F Y 3 A L R I L G I V W G F S V L F S L P N 4 Y L V S I V T M P L L Y F L F S T V Q I 5 F V L V L V F A I C W A P F H I D R L F 6 I P N V A S S L Y F F V G S V V H V L 7
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ICL1 Q A M K ICL1ECL1 Y P F L F ECL1ICL2 P F R A K L Q S ICL2ECL2 G I K F H Y F P N G S L V P G S A T C T V I K P M W ECL2ICL3 D E G ICL3ECL3 E E W S ECL3N-term M S G M E K L Q N A S W I Y Q Q K L E D P F Q K H L N S T E E Y L A F L C G P R N-termC-term K Q W H S Q H D P Q L P P A Q R N I F L T E C H F V E L T E D I G P Q F P C Q S S M H N S H L P A A L S S E Q M S R T N Y Q S F H F N K T C-term R S H F F L P V S V V Y V P I F V V G V I G N V L V C L V I L Q H T P T N Y Y L F S L A V S D L L V L L L G M P L E V Y E M W R N G P V G C Y F K T A L F E T V C F A S I L S I T T V S V E R Y V A I L H T R R R A L R I L G I V W G F S V L F S L P N T S I H I Y N F I I Q V T S F L F Y L L P M T V I S V L Y Y L M A L R L K K D K S L E A N A N I Q R P C R K S V N K M L F V L V L V F A I C W A P F H I D R L F F S F V E S L A A V F N L V H V V S G V F F Y L S S A V N P I I Y N L L S R R F Q N F H F Q A A V I S S
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Residue Table


GPCRdb(A)
GPCRdb(A)
NMU2 receptor
TM2
2x60 2.61x60 E102
2x63 2.64x63 E105
2x64 2.65x64 M106
TM3
3x32 3.32x32 F126
3x33 3.33x33 E127
ECL2
45x50 45.50x50 C204
TM5
5x35 5.35x35 Y213
TM6
6x51 6.51x51 F284
6x55 6.55x55 R288
6x58 6.58x58 F291
TM7
7x27 7.28x27 A302
7x30 7.31x30 F305
7x31 7.32x31 N306
7x34 7.35x34 H309
7x38 7.39x38 G313