GLP-1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7E14

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41467-021-24058-Z

PUBLICATION DATE

July 7, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

57 interactions (Click to see)

LIGANDS

N-Tert-butyl-6,7-dichloroquinoxalin-2-amine - Ago-PAM pubchem ,

orforglipron - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

glucagon-like peptide 1-(7-37), glucagon, glucagon-like peptide 1-(7-36) amide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 R 348 6x37 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 348 6x37 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 330 5x60 G.H5 L 388 G.H5.20
Polar TM6 R 348 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 348 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 R 348 6x37 G.H5 L 393 G.H5.25
Polar TM4 Q 263 4x40 G.HN Q 35 G.HN.52
Van-der-waals TM4 Q 263 4x40 G.HN Q 35 G.HN.52
Van-der-waals TM3 Y 250 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 356 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 331 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 251 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 V 259 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 V 259 - G.hns1 R 38 G.hns1.02
Polar TM5 K 334 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 334 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 334 5x64 G.H5 R 385 G.H5.17
Polar TM6 S 352 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 352 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 352 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM5 K 334 5x64 G.H5 L 394 G.H5.26
Polar TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Polar TM6 R 348 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 348 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 348 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM5 V 331 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 335 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 335 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 254 3x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 S 258 - G.S3 V 217 G.S3.01
Polar TM3 E 247 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 247 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 247 3x50 G.H5 Y 391 G.H5.23
Aromatic TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM5 V 331 5x61 G.H5 L 394 G.H5.26
Polar TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 V 327 5x57 G.H5 L 393 G.H5.25
Ionic TM5 K 334 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 334 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 334 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 334 5x64 G.H5 D 381 G.H5.13
Polar TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Ionic TM4 E 262 4x39 G.HN K 34 G.HN.51
Polar TM4 E 262 4x39 G.HN K 34 G.HN.51
Hydrophobic TM4 E 262 4x39 G.HN K 34 G.HN.51
Van-der-waals TM4 E 262 4x39 G.HN K 34 G.HN.51
Hydrophobic TM6 L 359 6x48 G.H5 Y 391 G.H5.23
Polar H8 N 407 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 N 407 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 N 407 8x48 G.H5 E 392 G.H5.24
Ionic TM4 E 262 4x39 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 L 251 3x54 G.H5 Y 391 G.H5.23
Polar TM3 L 254 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 254 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 254 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 255 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 255 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 255 3x58 G.H5 H 387 G.H5.19
Polar H8 N 406 8x47 G.H5 Q 390 G.H5.22
Hydrophobic TM5 K 334 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 V 259 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 V 259 - G.hns1 A 39 G.hns1.03
Hydrophobic TM5 V 327 5x57 G.H5 L 388 G.H5.20
Ionic TM6 K 351 6x40 G.H5 E 392 G.H5.24
Polar TM6 K 351 6x40 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 351 6x40 G.H5 E 392 G.H5.24
Hydrophobic TM4 Q 263 4x40 G.HN Q 31 G.HN.48
Van-der-waals TM4 Q 263 4x40 G.HN Q 31 G.HN.48
Hydrophobic TM7 Y 402 7x57 G.H5 Y 391 G.H5.23