Refined structure (7RMH) of Gs - NK1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 216 from structure (54.8%), 178 from model (45.2%)
Residue sidechains - 172 from structure (43.7%), 222 from model (56.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 AF2 AF2
G.HN 12 Q G.HN.29 AF2 AF2
G.HN 13 R G.HN.30 AF2 AF2
G.HN 14 N G.HN.31 Structure AF2
G.HN 15 E G.HN.32 Structure AF2
G.HN 16 E G.HN.33 Structure AF2
G.HN 17 K G.HN.34 Structure AF2
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure AF2
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure AF2
G.HN 25 K G.HN.42 Structure AF2
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure AF2
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure AF2
G.HN 32 K G.HN.49 Structure AF2
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure AF2
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure AF2
G.s1h1 50 E G.s1h1.04 Structure AF2
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure AF2
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure AF2
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 Structure AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 AF2 AF2
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure AF2
G.s2s3 216 K G.s2s3.02 Structure AF2
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure AF2
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure Structure
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure AF2
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure AF2
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure AF2
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure AF2
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure AF2
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure AF2
G.HG 296 L G.HG.03 Structure AF2
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure AF2
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 AF2 AF2
G.HG 305 K G.HG.12 AF2 AF2
G.HG 306 S G.HG.13 Structure AF2
G.HG 307 K G.HG.14 Structure AF2
G.HG 308 I G.HG.15 Structure AF2
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure AF2
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure AF2
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 AF2 AF2
G.hgh4 323 D G.hgh4.13 AF2 AF2
G.hgh4 324 A G.hgh4.14 AF2 AF2
G.hgh4 325 T G.hgh4.15 AF2 AF2
G.hgh4 326 P G.hgh4.16 AF2 AF2
G.hgh4 327 E G.hgh4.17 AF2 AF2
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure AF2
G.hgh4 331 D G.hgh4.21 Structure AF2
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure AF2
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure AF2
G.h4s6 353 G G.h4s6.09 AF2 AF2
G.h4s6 354 D G.h4s6.10 AF2 AF2
G.h4s6 355 G G.h4s6.11 AF2 AF2
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure AF2
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure AF2
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure AF2
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure AF2
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure AF2

REFINED GPCR RESIDUES

Residue backbones - 284 from structure (86.1%), 46 from model (13.9%)
Residue sidechains - 270 from structure (81.8%), 60 from model (18.2%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 N - AF2 AF2
N-term 4 V - AF2 AF2
N-term 5 L - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 V - AF2 AF2
N-term 8 D - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 D - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 P - AF2 AF2
N-term 14 N - AF2 AF2
N-term 15 I - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 T - AF2 AF2
N-term 18 N - AF2 AF2
N-term 19 T - AF2 AF2
N-term 20 S - AF2 AF2
N-term 21 E - AF2 AF2
N-term 22 P - AF2 AF2
N-term 23 N - Structure Structure
N-term 24 Q - Structure Structure
N-term 25 F - Structure Structure
N-term 26 V - Structure Structure
N-term 27 Q - Structure Structure
TM1 28 P 1.28x28 Structure Structure
TM1 29 A 1.29x29 Structure Structure
TM1 30 W 1.30x30 Structure Structure
TM1 31 Q 1.31x31 Structure Structure
TM1 32 I 1.32x32 Structure Structure
TM1 33 V 1.33x33 Structure Structure
TM1 34 L 1.34x34 Structure Structure
TM1 35 W 1.35x35 Structure Structure
TM1 36 A 1.36x36 Structure Structure
TM1 37 A 1.37x37 Structure Structure
TM1 38 A 1.38x38 Structure Structure
TM1 39 Y 1.39x39 Structure Structure
TM1 40 T 1.40x40 Structure Structure
TM1 41 V 1.41x41 Structure Structure
TM1 42 I 1.42x42 Structure Structure
TM1 43 V 1.43x43 Structure Structure
TM1 44 V 1.44x44 Structure Structure
TM1 45 T 1.45x45 Structure Structure
TM1 46 S 1.46x46 Structure Structure
TM1 47 V 1.47x47 Structure Structure
TM1 48 V 1.48x48 Structure Structure
TM1 49 G 1.49x49 Structure Structure
TM1 50 N 1.50x50 Structure Structure
TM1 51 V 1.51x51 Structure Structure
TM1 52 V 1.52x52 Structure Structure
TM1 53 V 1.53x53 Structure Structure
TM1 54 M 1.54x54 Structure Structure
TM1 55 W 1.55x55 Structure Structure
TM1 56 I 1.56x56 Structure Structure
TM1 57 I 1.57x57 Structure Structure
TM1 58 L 1.58x58 Structure Structure
TM1 59 A 1.59x59 Structure Structure
TM1 60 H 1.60x60 Structure Structure
ICL1 61 K 12.48x48 Structure AF2
ICL1 62 R 12.49x49 Structure AF2
ICL1 63 M 12.50x50 Structure Structure
ICL1 64 R 12.51x51 Structure Structure
TM2 65 T 2.37x37 Structure Structure
TM2 66 V 2.38x38 Structure Structure
TM2 67 T 2.39x39 Structure Structure
TM2 68 N 2.40x40 Structure Structure
TM2 69 Y 2.41x41 Structure Structure
TM2 70 F 2.42x42 Structure Structure
TM2 71 L 2.43x43 Structure Structure
TM2 72 V 2.44x44 Structure Structure
TM2 73 N 2.45x45 Structure Structure
TM2 74 L 2.46x46 Structure Structure
TM2 75 A 2.47x47 Structure Structure
TM2 76 F 2.48x48 Structure Structure
TM2 77 A 2.49x49 Structure Structure
TM2 78 E 2.50x50 Structure Structure
TM2 79 A 2.51x51 Structure Structure
TM2 80 S 2.52x52 Structure Structure
TM2 81 M 2.53x53 Structure Structure
TM2 82 A 2.54x54 Structure Structure
TM2 83 A 2.55x55 Structure Structure
TM2 84 F 2.56x56 Structure Structure
TM2 85 N 2.57x57 Structure Structure
TM2 86 T 2.58x58 Structure Structure
TM2 87 V 2.59x59 Structure Structure
TM2 88 V 2.60x60 Structure Structure
TM2 89 N 2.61x61 Structure Structure
TM2 90 F 2.62x62 Structure Structure
TM2 91 T 2.63x63 Structure Structure
TM2 92 Y 2.64x64 Structure Structure
TM2 93 A 2.65x65 Structure Structure
TM2 94 V 2.66x66 Structure Structure
TM2 95 H 2.67x67 Structure Structure
TM2 96 N 2.68x68 Structure Structure
ECL1 97 E 23.49x49 Structure Structure
ECL1 98 W 23.50x50 Structure Structure
ECL1 99 Y 23.51x51 Structure Structure
ECL1 100 Y 23.52x52 Structure Structure
TM3 101 G 3.21x21 Structure Structure
TM3 102 L 3.22x22 Structure Structure
TM3 103 F 3.23x23 Structure Structure
TM3 104 Y 3.24x24 Structure Structure
TM3 105 C 3.25x25 Structure Structure
TM3 106 K 3.26x26 Structure Structure
TM3 107 F 3.27x27 Structure Structure
TM3 108 H 3.28x28 Structure Structure
TM3 109 N 3.29x29 Structure Structure
TM3 110 F 3.30x30 Structure Structure
TM3 111 F 3.31x31 Structure Structure
TM3 112 P 3.32x32 Structure Structure
TM3 113 I 3.33x33 Structure Structure
TM3 114 A 3.34x34 Structure Structure
TM3 115 A 3.35x35 Structure Structure
TM3 116 V 3.36x36 Structure Structure
TM3 117 F 3.37x37 Structure Structure
TM3 118 A 3.38x38 Structure Structure
TM3 119 S 3.39x39 Structure Structure
TM3 120 I 3.40x40 Structure Structure
TM3 121 Y 3.41x41 Structure Structure
TM3 122 S 3.42x42 Structure Structure
TM3 123 M 3.43x43 Structure Structure
TM3 124 T 3.44x44 Structure Structure
TM3 125 A 3.45x45 Structure Structure
TM3 126 V 3.46x46 Structure Structure
TM3 127 A 3.47x47 Structure Structure
TM3 128 F 3.48x48 Structure Structure
TM3 129 D 3.49x49 Structure Structure
TM3 130 R 3.50x50 Structure Structure
TM3 131 Y 3.51x51 Structure Structure
TM3 132 M 3.52x52 Structure Structure
TM3 133 A 3.53x53 Structure Structure
TM3 134 I 3.54x54 Structure Structure
TM3 135 I 3.55x55 Structure Structure
TM3 136 H 3.56x56 Structure Structure
ICL2 137 P - Structure Structure
ICL2 138 L - Structure Structure
ICL2 139 Q - Structure Structure
ICL2 140 P - Structure Structure
ICL2 141 R - Structure Structure
ICL2 142 L - Structure Structure
TM4 143 S 4.38x38 Structure Structure
TM4 144 A 4.39x39 Structure Structure
TM4 145 T 4.40x40 Structure Structure
TM4 146 A 4.41x41 Structure Structure
TM4 147 T 4.42x42 Structure Structure
TM4 148 K 4.43x43 Structure Structure
TM4 149 V 4.44x44 Structure Structure
TM4 150 V 4.45x45 Structure Structure
TM4 151 I 4.46x46 Structure Structure
TM4 152 C 4.47x47 Structure Structure
TM4 153 V 4.48x48 Structure Structure
TM4 154 I 4.49x49 Structure Structure
TM4 155 W 4.50x50 Structure Structure
TM4 156 V 4.51x51 Structure Structure
TM4 157 L 4.52x52 Structure Structure
TM4 158 A 4.53x53 Structure Structure
TM4 159 L 4.54x54 Structure Structure
TM4 160 L 4.55x55 Structure Structure
TM4 161 L 4.56x56 Structure Structure
TM4 162 A 4.57x57 Structure Structure
TM4 163 F 4.58x59 Structure Structure
TM4 164 P 4.59x60 Structure Structure
TM4 165 Q 4.60x61 Structure Structure
TM4 166 G 4.61x62 Structure Structure
TM4 167 Y 4.62x63 Structure Structure
TM4 168 Y 4.63x64 Structure Structure
TM4 169 S 4.64x65 Structure Structure
ECL2 170 T - Structure Structure
ECL2 171 T - Structure Structure
ECL2 172 E - Structure Structure
ECL2 173 T - Structure Structure
ECL2 174 M - Structure Structure
ECL2 175 P - Structure Structure
ECL2 176 S - Structure Structure
ECL2 177 R - Structure Structure
ECL2 178 V - Structure Structure
ECL2 179 V - Structure Structure
ECL2 180 C 45.50x50 Structure Structure
ECL2 181 M 45.51x51 Structure Structure
ECL2 182 I 45.52x52 Structure Structure
ECL2 183 E - Structure Structure
ECL2 184 W - Structure Structure
ECL2 185 P - Structure Structure
ECL2 186 E - Structure AF2
ECL2 187 H - Structure Structure
TM5 188 P 5.30x31 Structure Structure
TM5 189 N 5.31x32 Structure AF2
TM5 190 K 5.32x33 Structure Structure
TM5 191 I 5.33x34 Structure Structure
TM5 192 Y 5.34x35 Structure Structure
TM5 193 E 5.35x36 Structure Structure
TM5 194 K 5.36x37 Structure Structure
TM5 195 V 5.37x38 Structure Structure
TM5 196 Y 5.38x39 Structure Structure
TM5 197 H 5.39x40 Structure Structure
TM5 198 I 5.40x41 Structure Structure
TM5 199 C 5.41x42 Structure Structure
TM5 200 V 5.42x43 Structure Structure
TM5 201 T 5.43x44 Structure Structure
TM5 202 V 5.44x45 Structure Structure
TM5 203 L 5.45x46 Structure Structure
TM5 204 I 5.46x461 Structure Structure
TM5 205 Y 5.47x47 Structure Structure
TM5 206 F 5.48x48 Structure Structure
TM5 207 L 5.49x49 Structure Structure
TM5 208 P 5.50x50 Structure Structure
TM5 209 L 5.51x51 Structure Structure
TM5 210 L 5.52x52 Structure Structure
TM5 211 V 5.53x53 Structure Structure
TM5 212 I 5.54x54 Structure Structure
TM5 213 G 5.55x55 Structure Structure
TM5 214 Y 5.56x56 Structure Structure
TM5 215 A 5.57x57 Structure Structure
TM5 216 Y 5.58x58 Structure Structure
TM5 217 T 5.59x59 Structure Structure
TM5 218 V 5.60x60 Structure Structure
TM5 219 V 5.61x61 Structure Structure
TM5 220 G 5.62x62 Structure Structure
TM5 221 I 5.63x63 Structure Structure
TM5 222 T 5.64x64 Structure Structure
TM5 223 L 5.65x65 Structure Structure
TM5 224 W 5.66x66 Structure Structure
TM5 225 A 5.67x67 AF2 AF2
TM5 226 S 5.68x68 AF2 AF2
TM5 227 E 5.69x69 AF2 AF2
TM5 228 I 5.70x70 AF2 AF2
TM5 229 P 5.71x71 AF2 AF2
TM5 230 G 5.72x72 AF2 AF2
TM5 231 D 5.73x73 AF2 AF2
ICL3 232 S - AF2 AF2
ICL3 233 S - AF2 AF2
ICL3 234 D - AF2 AF2
TM6 235 R 6.22x22 AF2 AF2
TM6 236 Y 6.23x23 AF2 AF2
TM6 237 H 6.24x24 AF2 AF2
TM6 238 E 6.25x25 AF2 AF2
TM6 239 Q 6.26x26 Structure Structure
TM6 240 V 6.27x27 Structure Structure
TM6 241 S 6.28x28 Structure Structure
TM6 242 A 6.29x29 Structure Structure
TM6 243 K 6.30x30 Structure Structure
TM6 244 R 6.31x31 Structure Structure
TM6 245 K 6.32x32 Structure Structure
TM6 246 V 6.33x33 Structure Structure
TM6 247 V 6.34x34 Structure Structure
TM6 248 K 6.35x35 Structure AF2
TM6 249 M 6.36x36 Structure Structure
TM6 250 M 6.37x37 Structure Structure
TM6 251 I 6.38x38 Structure Structure
TM6 252 V 6.39x39 Structure Structure
TM6 253 V 6.40x40 Structure Structure
TM6 254 V 6.41x41 Structure Structure
TM6 255 C 6.42x42 Structure Structure
TM6 256 T 6.43x43 Structure Structure
TM6 257 F 6.44x44 Structure Structure
TM6 258 A 6.45x45 Structure Structure
TM6 259 I 6.46x46 Structure AF2
TM6 260 C 6.47x47 Structure Structure
TM6 261 W 6.48x48 Structure Structure
TM6 262 L 6.49x49 Structure Structure
TM6 263 P 6.50x50 Structure Structure
TM6 264 F 6.51x51 Structure Structure
TM6 265 H 6.52x52 Structure Structure
TM6 266 I 6.53x53 Structure Structure
TM6 267 F 6.54x54 Structure Structure
TM6 268 F 6.55x55 Structure Structure
TM6 269 L 6.56x56 Structure Structure
TM6 270 L 6.57x57 Structure Structure
TM6 271 P 6.58x58 Structure Structure
TM6 272 Y 6.59x59 Structure Structure
TM6 273 I 6.60x60 Structure AF2
TM6 274 N 6.61x61 Structure Structure
ECL3 275 P - Structure Structure
ECL3 276 D - Structure Structure
ECL3 277 L - Structure Structure
ECL3 278 Y - Structure Structure
ECL3 279 L - Structure Structure
ECL3 280 K - Structure AF2
TM7 281 K 7.29x28 Structure Structure
TM7 282 F 7.30x29 Structure Structure
TM7 283 I 7.31x30 Structure Structure
TM7 284 Q 7.32x31 Structure Structure
TM7 285 Q 7.33x32 Structure Structure
TM7 286 V 7.34x33 Structure Structure
TM7 287 Y 7.35x34 Structure Structure
TM7 288 L 7.36x35 Structure Structure
TM7 289 A 7.37x36 Structure Structure
TM7 290 I 7.38x37 Structure Structure
TM7 291 M 7.39x38 Structure Structure
TM7 292 W 7.40x39 Structure Structure
TM7 293 L 7.41x40 Structure Structure
TM7 294 A 7.42x41 Structure Structure
TM7 295 M 7.43x42 Structure Structure
TM7 296 S 7.44x43 Structure Structure
TM7 297 S 7.45x45 Structure Structure
TM7 298 T 7.46x46 Structure Structure
TM7 299 M 7.47x47 Structure Structure
TM7 300 Y 7.48x48 Structure Structure
TM7 301 N 7.49x49 Structure Structure
TM7 302 P 7.50x50 Structure Structure
TM7 303 I 7.51x51 Structure Structure
TM7 304 I 7.52x52 Structure Structure
TM7 305 Y 7.53x53 Structure Structure
TM7 306 C 7.54x54 Structure Structure
TM7 307 C 7.55x55 Structure Structure
TM7 308 L 7.56x56 Structure Structure
H8 309 N 8.47x47 Structure Structure
H8 310 D 8.48x48 Structure AF2
H8 311 R 8.49x49 Structure AF2
H8 312 F 8.50x50 Structure Structure
H8 313 R 8.51x51 Structure Structure
H8 314 L 8.52x52 Structure AF2
H8 315 G 8.53x53 Structure Structure
H8 316 F 8.54x54 Structure Structure
H8 317 K 8.55x55 Structure AF2
H8 318 H 8.56x56 Structure AF2
H8 319 A 8.57x57 Structure Structure
H8 320 F 8.58x58 Structure AF2
C-term 321 R - AF2 AF2
C-term 322 C - AF2 AF2
C-term 323 C - AF2 AF2
C-term 324 P - AF2 AF2
C-term 325 F - AF2 AF2
C-term 326 I - AF2 AF2
C-term 327 S - AF2 AF2
C-term 328 A - AF2 AF2
C-term 329 G - AF2 AF2
C-term 330 D - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 K 245 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 245 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 138 - G.S3 V 217 G.S3.01
Polar TM6 Q 239 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM6 Q 239 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 Q 239 6x26 G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 137 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 137 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 137 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 137 - G.H5 R 380 G.H5.12
Hydrophobic H8 F 312 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 F 312 8x50 G.H5 E 392 G.H5.24
Hydrophobic TM2 T 67 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 67 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 138 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 138 - G.H5 F 376 G.H5.08
Polar ICL2 L 138 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 138 - G.S1 H 41 G.S1.02
Hydrophobic TM6 Y 236 6x23 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 D 231 5x73 G.H4 L 346 G.H4.16
Hydrophobic TM5 P 229 5x71 G.S6 Y 360 G.S6.02
Van-der-waals TM5 P 229 5x71 G.S6 Y 360 G.S6.02
Van-der-waals TM2 N 68 2x40 G.H5 E 392 G.H5.24
Hydrophobic TM3 A 133 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 133 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 138 - G.S3 F 219 G.S3.03
Hydrophobic ICL2 P 137 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 D 231 5x73 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 D 231 5x73 G.hgh4 D 323 G.hgh4.13
Polar ICL2 P 137 - G.H5 H 387 G.H5.19
Hydrophobic TM3 I 134 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 134 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 R 130 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM7 L 308 7x56 G.H5 L 394 G.H5.26
Van-der-waals TM7 L 308 7x56 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 138 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 138 - G.H5 R 380 G.H5.12
Hydrophobic TM6 M 249 6x36 G.H5 L 393 G.H5.25
Polar TM3 I 135 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM6 A 242 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM6 V 246 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 246 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 P 229 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 P 229 5x71 G.H5 D 381 G.H5.13
Ionic TM5 D 231 5x73 G.H4 R 342 G.H4.12
Hydrophobic TM5 D 231 5x73 G.H4 R 342 G.H4.12
Van-der-waals TM5 D 231 5x73 G.H4 R 342 G.H4.12
Hydrophobic ICL2 L 138 - G.H5 C 379 G.H5.11
Hydrophobic TM7 L 308 7x56 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 134 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 G 230 5x72 G.S6 P 361 G.S6.03
Hydrophobic H8 N 309 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 309 8x47 G.H5 E 392 G.H5.24
Van-der-waals ICL2 R 141 - G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 223 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM3 D 129 3x49 G.H5 Y 391 G.H5.23