CB1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9ERX

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

June 26, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

52 interactions (Click to see)

LIGANDS

HU-210 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

anandamide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 214 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 214 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 214 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 M 337 6x29 G.H5 L 348 G.H5.20
Polar ICL3 Q 314 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Q 314 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 T 313 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 T 313 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 T 313 - G.H5 D 337 G.H5.09
Hydrophobic TM6 M 337 6x29 G.H5 K 345 G.H5.17
Polar ICL2 P 221 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 221 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 221 - G.H5 N 347 G.H5.19
Hydrophobic H8 S 401 8x47 G.H5 F 354 G.H5.26
Hydrophobic H8 S 401 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 222 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 222 - G.H5 I 343 G.H5.15
Polar TM2 R 150 2x37 G.H5 K 349 G.H5.21
Polar TM3 R 214 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 214 3x50 G.H5 G 352 G.H5.24
Polar H8 K 402 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 K 402 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 402 8x48 G.H5 F 354 G.H5.26
Ionic TM5 H 304 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 304 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 304 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 304 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 R 226 - G.HN E 28 G.HN.52
Hydrophobic TM6 L 341 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Y 224 - G.H5 N 347 G.H5.19
Van-der-waals TM7 R 400 7x56 G.H5 F 354 G.H5.26
Hydrophobic ICL3 T 313 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 L 222 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 L 222 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 222 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 M 308 5x72 G.H5 D 341 G.H5.13
Hydrophobic ICL3 G 312 - G.H5 F 334 G.H5.06
Hydrophobic ICL2 R 226 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 226 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 221 - G.H5 I 343 G.H5.15
Polar TM2 S 152 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 152 2x39 G.H5 C 351 G.H5.23
Ionic TM5 R 311 5x75 G.H5 D 337 G.H5.09
Polar TM5 R 311 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 311 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 311 5x75 G.H5 D 337 G.H5.09
Hydrophobic ICL3 Q 314 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 I 297 5x61 G.H5 L 353 G.H5.25
Polar TM3 S 217 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 217 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 221 - G.H5 I 344 G.H5.16
Hydrophobic TM6 M 337 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 M 337 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL3 T 313 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 T 313 - G.H5 F 334 G.H5.06
Hydrophobic TM5 M 308 5x72 G.H5 D 337 G.H5.09
Polar TM3 S 217 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 217 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 217 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 222 - G.S3 L 194 G.S3.01
Aromatic TM6 R 340 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 340 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 340 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 345 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 345 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 H 304 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 304 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 341 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 337 6x29 G.H5 I 344 G.H5.16
Van-der-waals TM6 M 337 6x29 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 341 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 341 6x33 G.H5 L 348 G.H5.20
Ionic TM2 R 150 2x37 G.H5 D 350 G.H5.22
Polar TM2 R 150 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 150 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 150 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM6 T 344 6x36 G.H5 L 353 G.H5.25
Polar ICL2 K 225 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 225 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 225 - G.H5 N 347 G.H5.19
Hydrophobic TM2 Y 153 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 218 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 H 304 5x68 G.H5 T 340 G.H5.12
Hydrophobic ICL3 T 313 - G.H5 A 338 G.H5.10
Hydrophobic TM3 R 214 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 214 3x50 G.H5 L 353 G.H5.25