CX3CR1 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XBW

RESOLUTION

2.8 Å

REFERENCE

10.1126/SCIADV.ABN8048

PUBLICATION DATE

July 13, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

CX3CL1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 D 67 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM2 D 67 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 D 67 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM6 A 229 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 229 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 134 34x50 G.H5 T 340 G.H5.12
Hydrophobic H8 K 299 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 K 299 8x49 G.H5 F 354 G.H5.26
Hydrophobic ICL2 M 138 34x54 G.S1 V 34 G.S1.02
Van-der-waals ICL2 M 138 34x54 G.S1 V 34 G.S1.02
Hydrophobic ICL3 N 223 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 N 223 - G.H5 K 345 G.H5.17
Hydrophobic TM5 T 217 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 230 6x34 G.H5 L 348 G.H5.20
Polar TM3 R 127 3x50 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 127 3x50 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 127 3x50 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 131 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 131 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 135 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 Q 144 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 144 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 134 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM1 L 56 1x57 G.H5 L 353 G.H5.25
Van-der-waals TM1 L 56 1x57 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 218 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 131 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 M 138 34x54 G.S3 L 194 G.S3.01
Polar TM2 D 67 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 D 67 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 D 67 2x40 G.H5 G 352 G.H5.24
Polar ICL2 N 139 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 139 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic H8 K 299 8x49 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 131 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 M 138 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 138 34x54 G.hns1 R 32 G.hns1.03
Polar TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 N 347 G.H5.19
Polar TM2 T 66 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 K 226 6x30 G.H5 K 345 G.H5.17
Polar TM2 S 64 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 64 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 64 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL3 N 223 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 Q 144 - G.HN E 28 G.HN.52
Van-der-waals ICL2 Q 144 - G.HN E 28 G.HN.52
Hydrophobic TM6 K 228 6x32 G.H5 F 354 G.H5.26
Hydrophobic H8 F 300 8x50 G.H5 L 353 G.H5.25
Van-der-waals H8 F 300 8x50 G.H5 L 353 G.H5.25
Hydrophobic TM2 L 70 2x43 G.H5 L 353 G.H5.25
Van-der-waals TM2 L 70 2x43 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 226 6x30 G.H5 L 348 G.H5.20
Hydrophobic ICL2 M 138 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 138 34x54 G.H5 I 343 G.H5.15
Ionic TM3 R 127 3x50 G.H5 D 350 G.H5.22
Polar TM3 R 127 3x50 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 127 3x50 G.H5 D 350 G.H5.22
Van-der-waals TM3 R 127 3x50 G.H5 D 350 G.H5.22
Hydrophobic TM7 Y 293 7x53 G.H5 L 353 G.H5.25
Van-der-waals TM7 Y 293 7x53 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 134 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 134 34x50 G.H5 I 343 G.H5.15
Polar H8 K 299 8x49 G.H5 C 351 G.H5.23
Van-der-waals H8 K 299 8x49 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 141 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 141 34x57 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 227 6x31 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 227 6x31 G.H5 L 348 G.H5.20
Hydrophobic H8 K 299 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 K 299 8x49 G.H5 G 352 G.H5.24
Hydrophobic ICL2 A 135 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM2 T 66 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM1 V 52 1x53 G.H5 L 353 G.H5.25
Ionic ICL2 H 145 - G.HN E 28 G.HN.52
Polar ICL2 H 145 - G.HN E 28 G.HN.52
Hydrophobic ICL2 H 145 - G.HN E 28 G.HN.52
Van-der-waals ICL2 H 145 - G.HN E 28 G.HN.52
Hydrophobic TM6 L 232 6x36 G.H5 F 354 G.H5.26
Hydrophobic H8 G 297 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 G 297 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM1 A 55 1x56 G.H5 L 353 G.H5.25
Van-der-waals TM1 A 55 1x56 G.H5 L 353 G.H5.25
Hydrophobic TM2 L 70 2x43 G.H5 C 351 G.H5.23
Van-der-waals TM2 L 70 2x43 G.H5 C 351 G.H5.23
Polar TM2 D 67 2x40 G.H5 L 353 G.H5.25
Polar ICL2 N 139 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 139 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 139 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 229 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 229 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 N 140 34x56 G.hns1 R 32 G.hns1.03