PDB
7XBW
Resolution
2.8 Å
Released
July 13, 2022
Receptor
CX3CR1
Class
A
Species
Homo sapiens
Ligand
Cholesterol
Function
PAM
Reference
10.1126/SCIADV.ABN8048

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Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol L75 2.48x48 TM2 hydrophobic
Cholesterol L79 2.52x52 TM2 hydrophobic
Cholesterol L151 4.47x47 TM4 hydrophobic
Cholesterol W154 4.50x50 TM4 hydrophobic
Cholesterol I158 4.54x54 TM4 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K K P K ICL1ECL1 E K G L H N A ECL1ICL2 A A N S M N N R ICL2ECL2 K Q K E N E C L G D Y P E V ECL2ICL3 K N ICL3ECL3 F F P ECL3N-term M D Q F P E S V T E N F E Y D D L A E A C Y N-termC-term C L A V L C G R S V H V D F S S S E S Q R S R H G S V L S S N F T Y H T S D G D A L L L L C-term I G D I V V F G T V F L S I F Y S V I F A I G L V G N L L V V F A L T N S S V T D I Y L L N L A L S D L L F V A T L P F W T H Y L I N M C K F T T A F F F I G F F G S I F F I T V I S I D R Y L A I V L T V Q H G V T I S L G V W A A A I L V A A P Q F M F T L Q E I W P V L R N V E T N F L G F L L P L L I M S Y C Y F R I I Q T L F S C H K K A K A I K L I L L V V I V F F L F W T P Y N V M I F L E T L K L Y D S C D M R K D L R L A L S V T E T V A F S H C C L N P L I Y A F A G E K L Y H F R R Y L Y G K
Helix box plot — Download: PNG | SVG L N G V L G I A F I V S Y F I S L F V T 1 L N L A L S D L L F V A T L P F W T H Y 2 V T I F F I S G F F G I F F F A T T F K 3 G V T I S L G V W A A A I L V A A P Q 4 Y C Y S M I L L P L L F G L F N T E V N R 5 L L V V I V F F L F W T P Y N V M I F L 6 L P N L C C H S F A V T E T V S L A L 7

GPCRdb(A)
GPCRdb(A)
CX3CR1
TM2
2x48 2.48x48 L75
2x52 2.52x52 L79
TM4
4x47 4.47x47 L151
4x50 4.50x50 W154
4x54 4.54x54 I158