Refined structure (6VN7) of Gs - VPAC1 receptor

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 239 from structure (60.7%), 155 from model (39.3%)
Residue sidechains - 231 from structure (58.6%), 163 from model (41.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 Structure Structure
G.HN 10 E G.HN.27 Structure Structure
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure Structure
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 Structure Structure
G.H1 62 I G.H1.10 Structure Structure
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 Structure Structure
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure Structure
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 Structure Structure
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 Structure Structure
G.s4h3 262 Q G.s4h3.13 Structure Structure
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 263 from structure (61.6%), 164 from model (38.4%)
Residue sidechains - 263 from structure (61.6%), 164 from model (38.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 R - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 P - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 P - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 R - AF2 AF2
N-term 11 W - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 C - AF2 AF2
N-term 14 V - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 A - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 L - AF2 AF2
N-term 20 A - AF2 AF2
N-term 21 W - AF2 AF2
N-term 22 A - AF2 AF2
N-term 23 L - AF2 AF2
N-term 24 G - AF2 AF2
N-term 25 P - AF2 AF2
N-term 26 A - AF2 AF2
N-term 27 G - AF2 AF2
N-term 28 G - AF2 AF2
N-term 29 Q - AF2 AF2
N-term 30 A - AF2 AF2
N-term 31 A - AF2 AF2
N-term 32 R - AF2 AF2
N-term 33 L - AF2 AF2
N-term 34 Q - AF2 AF2
N-term 35 E - AF2 AF2
N-term 36 E - AF2 AF2
N-term 37 C - AF2 AF2
N-term 38 D - AF2 AF2
N-term 39 Y - AF2 AF2
N-term 40 V - AF2 AF2
N-term 41 Q - AF2 AF2
N-term 42 M - AF2 AF2
N-term 43 I - AF2 AF2
N-term 44 E - AF2 AF2
N-term 45 V - AF2 AF2
N-term 46 Q - AF2 AF2
N-term 47 H - AF2 AF2
N-term 48 K - AF2 AF2
N-term 49 Q - AF2 AF2
N-term 50 C - AF2 AF2
N-term 51 L - AF2 AF2
N-term 52 E - AF2 AF2
N-term 53 E - AF2 AF2
N-term 54 A - AF2 AF2
N-term 55 Q - AF2 AF2
N-term 56 L - AF2 AF2
N-term 57 E - AF2 AF2
N-term 58 N - AF2 AF2
N-term 59 E - AF2 AF2
N-term 60 T - AF2 AF2
N-term 61 I - AF2 AF2
N-term 62 G - AF2 AF2
N-term 63 C - AF2 AF2
N-term 64 S - AF2 AF2
N-term 65 K - AF2 AF2
N-term 66 M - AF2 AF2
N-term 67 W - AF2 AF2
N-term 68 D - AF2 AF2
N-term 69 N - AF2 AF2
N-term 70 L - AF2 AF2
N-term 71 T - AF2 AF2
N-term 72 C - AF2 AF2
N-term 73 W - AF2 AF2
N-term 74 P - AF2 AF2
N-term 75 A - AF2 AF2
N-term 76 T - AF2 AF2
N-term 77 P - AF2 AF2
N-term 78 R - AF2 AF2
N-term 79 G - AF2 AF2
N-term 80 Q - AF2 AF2
N-term 81 V - AF2 AF2
N-term 82 V - AF2 AF2
N-term 83 V - AF2 AF2
N-term 84 L - AF2 AF2
N-term 85 A - AF2 AF2
N-term 86 C - AF2 AF2
N-term 87 P - AF2 AF2
N-term 88 L - AF2 AF2
N-term 89 I - AF2 AF2
N-term 90 F - AF2 AF2
N-term 91 K - AF2 AF2
N-term 92 L - AF2 AF2
N-term 93 F - AF2 AF2
N-term 94 S - AF2 AF2
N-term 95 S - AF2 AF2
N-term 96 I - AF2 AF2
N-term 97 Q - AF2 AF2
N-term 98 G - AF2 AF2
N-term 99 R - AF2 AF2
N-term 100 N - AF2 AF2
N-term 101 V - AF2 AF2
N-term 102 S - AF2 AF2
N-term 103 R - AF2 AF2
N-term 104 S - AF2 AF2
N-term 105 C - AF2 AF2
N-term 106 T - AF2 AF2
N-term 107 D - AF2 AF2
N-term 108 E - AF2 AF2
N-term 109 G - AF2 AF2
N-term 110 W - AF2 AF2
N-term 111 T - AF2 AF2
N-term 112 H - AF2 AF2
N-term 113 L - AF2 AF2
N-term 114 E - AF2 AF2
N-term 115 P - AF2 AF2
N-term 116 G - AF2 AF2
N-term 117 P - AF2 AF2
N-term 118 Y - AF2 AF2
N-term 119 P - AF2 AF2
N-term 120 I - AF2 AF2
N-term 121 A - AF2 AF2
N-term 122 C - AF2 AF2
N-term 123 G - AF2 AF2
N-term 124 L - AF2 AF2
N-term 125 D - AF2 AF2
N-term 126 D - AF2 AF2
N-term 127 K - AF2 AF2
N-term 128 A - AF2 AF2
TM1 129 A 1.26x26 Structure Structure
TM1 130 S 1.27x27 Structure Structure
TM1 131 L 1.28x28 Structure Structure
TM1 132 D 1.29x29 Structure Structure
TM1 133 E 1.30x30 Structure Structure
TM1 134 Q 1.31x31 Structure Structure
TM1 135 Q 1.32x32 Structure Structure
TM1 136 T 1.33x33 Structure Structure
TM1 137 M 1.34x34 Structure Structure
TM1 138 F 1.35x35 Structure Structure
TM1 139 Y 1.36x36 Structure Structure
TM1 140 G 1.37x37 Structure Structure
TM1 141 S 1.38x38 Structure Structure
TM1 142 V 1.39x39 Structure Structure
TM1 143 K 1.40x40 Structure Structure
TM1 144 T 1.41x41 Structure Structure
TM1 145 G 1.42x42 Structure Structure
TM1 146 Y 1.43x43 Structure Structure
TM1 147 T 1.44x44 Structure Structure
TM1 148 I 1.45x45 Structure Structure
TM1 149 G 1.46x46 Structure Structure
TM1 150 Y 1.47x47 Structure Structure
TM1 151 G 1.48x48 Structure Structure
TM1 152 L 1.49x49 Structure Structure
TM1 153 S 1.50x50 Structure Structure
TM1 154 L 1.51x51 Structure Structure
TM1 155 A 1.52x52 Structure Structure
TM1 156 T 1.53x53 Structure Structure
TM1 157 L 1.54x54 Structure Structure
TM1 158 L 1.55x55 Structure Structure
TM1 159 V 1.56x56 Structure Structure
TM1 160 A 1.57x57 Structure Structure
TM1 161 T 1.58x58 Structure Structure
TM1 162 A 1.59x59 Structure Structure
TM1 163 I 1.60x60 Structure Structure
TM1 164 L 1.61x61 Structure Structure
TM1 165 S 1.62x62 Structure Structure
TM1 166 L 1.63x63 Structure Structure
TM1 167 F 1.64x64 Structure Structure
ICL1 168 R 12.48x48 Structure Structure
ICL1 169 K 12.49x49 Structure Structure
ICL1 170 L 12.50x50 Structure Structure
ICL1 171 H 12.51x51 Structure Structure
TM2 172 C 2.44x44 Structure Structure
TM2 173 T 2.45x45 Structure Structure
TM2 174 R 2.46x46 Structure Structure
TM2 175 N 2.47x47 Structure Structure
TM2 176 Y 2.48x48 Structure Structure
TM2 177 I 2.49x49 Structure Structure
TM2 178 H 2.50x50 Structure Structure
TM2 179 M 2.51x51 Structure Structure
TM2 180 H 2.52x52 Structure Structure
TM2 181 L 2.53x53 Structure Structure
TM2 182 F 2.54x54 Structure Structure
TM2 183 I 2.55x55 Structure Structure
TM2 184 S 2.56x56 Structure Structure
TM2 185 F 2.57x57 Structure Structure
TM2 186 I 2.58x58 Structure Structure
TM2 187 L 2.59x59 Structure Structure
TM2 188 R 2.60x60 Structure Structure
TM2 189 A 2.61x61 Structure Structure
TM2 190 A 2.62x62 Structure Structure
TM2 191 A 2.63x63 Structure Structure
TM2 192 V 2.64x64 Structure Structure
TM2 193 F 2.65x65 Structure Structure
TM2 194 I 2.66x66 Structure Structure
TM2 195 K 2.67x67 Structure Structure
TM2 196 D 2.68x68 Structure Structure
TM2 197 L 2.69x69 Structure Structure
TM2 198 A 2.70x70 Structure Structure
TM2 199 L 2.71x71 Structure Structure
ECL1 200 F - Structure Structure
ECL1 201 D - Structure Structure
ECL1 202 S - AF2 AF2
ECL1 203 G - AF2 AF2
ECL1 204 E - AF2 AF2
ECL1 205 S - AF2 AF2
ECL1 206 D - AF2 AF2
ECL1 207 Q - AF2 AF2
ECL1 208 C - AF2 AF2
ECL1 209 S - AF2 AF2
ECL1 210 E - AF2 AF2
ECL1 211 G - AF2 AF2
TM3 212 S 3.26x26 Structure Structure
TM3 213 V 3.27x27 Structure Structure
TM3 214 G 3.28x28 Structure Structure
TM3 215 C 3.29x29 Structure Structure
TM3 216 K 3.30x30 Structure Structure
TM3 217 A 3.31x31 Structure Structure
TM3 218 A 3.32x32 Structure Structure
TM3 219 M 3.33x33 Structure Structure
TM3 220 V 3.34x34 Structure Structure
TM3 221 F 3.35x35 Structure Structure
TM3 222 F 3.36x36 Structure Structure
TM3 223 Q 3.37x37 Structure Structure
TM3 224 Y 3.38x38 Structure Structure
TM3 225 C 3.39x39 Structure Structure
TM3 226 V 3.40x40 Structure Structure
TM3 227 M 3.41x41 Structure Structure
TM3 228 A 3.42x42 Structure Structure
TM3 229 N 3.43x43 Structure Structure
TM3 230 F 3.44x44 Structure Structure
TM3 231 F 3.45x45 Structure Structure
TM3 232 W 3.46x46 Structure Structure
TM3 233 L 3.47x47 Structure Structure
TM3 234 L 3.48x48 Structure Structure
TM3 235 V 3.49x49 Structure Structure
TM3 236 E 3.50x50 Structure Structure
TM3 237 G 3.51x51 Structure Structure
TM3 238 L 3.52x52 Structure Structure
TM3 239 Y 3.53x53 Structure Structure
TM3 240 L 3.54x54 Structure Structure
TM3 241 Y 3.55x55 Structure Structure
TM3 242 T 3.56x56 Structure Structure
TM3 243 L 3.57x57 Structure Structure
TM3 244 L 3.58x58 Structure Structure
TM3 245 A 3.59x59 Structure Structure
TM3 246 V 3.60x60 Structure Structure
ICL2 247 S - Structure Structure
ICL2 248 F - Structure Structure
ICL2 249 F - Structure Structure
TM4 250 S 4.37x38 Structure Structure
TM4 251 E 4.38x39 Structure Structure
TM4 252 R 4.39x40 Structure Structure
TM4 253 K 4.40x41 Structure Structure
TM4 254 Y 4.41x42 Structure Structure
TM4 255 F 4.42x43 Structure Structure
TM4 256 W 4.43x44 Structure Structure
TM4 257 G 4.44x45 Structure Structure
TM4 258 Y 4.45x46 Structure Structure
TM4 259 I 4.46x47 Structure Structure
TM4 260 L 4.47x48 Structure Structure
TM4 261 I 4.48x49 Structure Structure
TM4 262 G 4.49x491 Structure Structure
TM4 263 W 4.50x50 Structure Structure
TM4 264 G 4.51x51 Structure Structure
TM4 265 V 4.52x52 Structure Structure
TM4 266 P 4.53x53 Structure Structure
TM4 267 S 4.54x54 Structure Structure
TM4 268 T 4.55x55 Structure Structure
TM4 269 F 4.56x56 Structure Structure
TM4 270 T 4.57x57 Structure Structure
TM4 271 M 4.58x58 Structure Structure
TM4 272 V 4.59x59 Structure Structure
TM4 273 W 4.60x60 Structure Structure
TM4 274 T 4.61x61 Structure Structure
TM4 275 I 4.62x62 Structure Structure
TM4 276 A 4.63x63 Structure Structure
TM4 277 R 4.64x64 Structure Structure
TM4 278 I 4.65x65 Structure Structure
TM4 279 H 4.66x66 Structure Structure
TM4 280 F 4.67x67 Structure Structure
TM4 281 E 4.68x68 Structure Structure
ECL2 282 D - Structure Structure
ECL2 283 Y - Structure Structure
ECL2 284 G - Structure Structure
ECL2 285 C 45.50x50 Structure Structure
ECL2 286 W 45.51x51 Structure Structure
ECL2 287 D 45.52x52 Structure Structure
ECL2 288 T - Structure Structure
ECL2 289 I - Structure Structure
TM5 290 N 5.32x33 Structure Structure
TM5 291 S 5.33x34 Structure Structure
TM5 292 S 5.34x35 Structure Structure
TM5 293 L 5.35x36 Structure Structure
TM5 294 W 5.36x37 Structure Structure
TM5 295 W 5.37x38 Structure Structure
TM5 296 I 5.38x381 Structure Structure
TM5 297 I 5.39x39 Structure Structure
TM5 298 K 5.40x40 Structure Structure
TM5 299 G 5.41x41 Structure Structure
TM5 300 P 5.42x42 Structure Structure
TM5 301 I 5.43x43 Structure Structure
TM5 302 L 5.44x44 Structure Structure
TM5 303 T 5.45x45 Structure Structure
TM5 304 S 5.46x46 Structure Structure
TM5 305 I 5.47x47 Structure Structure
TM5 306 L 5.48x48 Structure Structure
TM5 307 V 5.49x49 Structure Structure
TM5 308 N 5.50x50 Structure Structure
TM5 309 F 5.51x51 Structure Structure
TM5 310 I 5.52x52 Structure Structure
TM5 311 L 5.53x53 Structure Structure
TM5 312 F 5.54x54 Structure Structure
TM5 313 I 5.55x55 Structure Structure
TM5 314 C 5.56x56 Structure Structure
TM5 315 I 5.57x57 Structure Structure
TM5 316 I 5.58x58 Structure Structure
TM5 317 R 5.59x59 Structure Structure
TM5 318 I 5.60x60 Structure Structure
TM5 319 L 5.61x61 Structure Structure
TM5 320 L 5.62x62 Structure Structure
TM5 321 Q 5.63x63 Structure Structure
TM5 322 K 5.64x64 Structure Structure
TM5 323 L 5.65x65 Structure Structure
ICL3 324 R - Structure Structure
ICL3 325 P - Structure Structure
ICL3 326 P - Structure Structure
ICL3 327 D - AF2 AF2
ICL3 328 I - AF2 AF2
ICL3 329 R - AF2 AF2
ICL3 330 K - AF2 AF2
TM6 331 S 6.30x30 AF2 AF2
TM6 332 D 6.31x31 AF2 AF2
TM6 333 S 6.32x32 AF2 AF2
TM6 334 S 6.33x33 AF2 AF2
TM6 335 P 6.34x34 Structure Structure
TM6 336 Y 6.35x35 Structure Structure
TM6 337 S 6.36x36 Structure Structure
TM6 338 R 6.37x37 Structure Structure
TM6 339 L 6.38x38 Structure Structure
TM6 340 A 6.39x39 Structure Structure
TM6 341 R 6.40x40 Structure Structure
TM6 342 S 6.41x41 Structure Structure
TM6 343 T 6.42x42 Structure Structure
TM6 344 L 6.43x43 Structure Structure
TM6 345 L 6.44x44 Structure Structure
TM6 346 L 6.45x45 Structure Structure
TM6 347 I 6.46x46 Structure Structure
TM6 348 P 6.47x47 Structure Structure
TM6 349 L 6.48x48 Structure Structure
TM6 350 F 6.49x49 Structure Structure
TM6 351 G 6.50x50 Structure Structure
TM6 352 V 6.51x51 Structure Structure
TM6 353 H 6.52x52 Structure Structure
TM6 354 Y 6.53x53 Structure Structure
TM6 355 I 6.54x54 Structure Structure
TM6 356 M 6.55x55 Structure Structure
TM6 357 F 6.56x56 Structure Structure
TM6 358 A 6.57x57 Structure Structure
TM6 359 F 6.58x58 Structure Structure
TM6 360 F 6.59x59 Structure Structure
ECL3 361 P - Structure Structure
ECL3 362 D - Structure Structure
ECL3 363 N - Structure Structure
ECL3 364 F - Structure Structure
ECL3 365 K - Structure Structure
TM7 366 P 7.35x34 Structure Structure
TM7 367 E 7.36x35 Structure Structure
TM7 368 V 7.37x36 Structure Structure
TM7 369 K 7.38x37 Structure Structure
TM7 370 M 7.39x38 Structure Structure
TM7 371 V 7.40x39 Structure Structure
TM7 372 F 7.41x40 Structure Structure
TM7 373 E 7.42x41 Structure Structure
TM7 374 L 7.43x42 Structure Structure
TM7 375 V 7.44x43 Structure Structure
TM7 376 V 7.45x44 Structure Structure
TM7 377 G 7.46x45 Structure Structure
TM7 378 S 7.47x46 Structure Structure
TM7 379 F 7.48x47 Structure Structure
TM7 380 Q 7.49x49 Structure Structure
TM7 381 G 7.50x50 Structure Structure
TM7 382 F 7.51x51 Structure Structure
TM7 383 V 7.52x52 Structure Structure
TM7 384 V 7.53x53 Structure Structure
TM7 385 A 7.54x54 Structure Structure
TM7 386 I 7.55x55 Structure Structure
TM7 387 L 7.56x56 Structure Structure
TM7 388 Y 7.57x57 Structure Structure
TM7 389 C 7.58x58 Structure Structure
TM7 390 F 7.59x59 Structure Structure
TM7 391 L 7.60x60 Structure Structure
H8 392 N 8.47x47 Structure Structure
H8 393 G 8.48x48 Structure Structure
H8 394 E 8.49x49 Structure Structure
H8 395 V 8.50x50 Structure Structure
H8 396 Q 8.51x51 Structure Structure
H8 397 A 8.52x52 Structure Structure
H8 398 E 8.53x53 Structure Structure
H8 399 L 8.54x54 Structure Structure
H8 400 R 8.55x55 Structure Structure
H8 401 R 8.56x56 Structure Structure
H8 402 K 8.57x57 Structure Structure
H8 403 W 8.58x58 Structure Structure
H8 404 R 8.59x59 Structure Structure
H8 405 R 8.60x60 Structure Structure
H8 406 W 8.61x61 Structure Structure
H8 407 H 8.62x62 Structure Structure
H8 408 L 8.63x63 Structure Structure
H8 409 Q 8.64x64 Structure Structure
H8 410 G 8.65x65 AF2 AF2
H8 411 V 8.66x66 AF2 AF2
H8 412 L 8.67x67 AF2 AF2
H8 413 G 8.68x68 AF2 AF2
H8 414 W 8.69x69 AF2 AF2
H8 415 N 8.70x70 AF2 AF2
H8 416 P 8.71x71 AF2 AF2
H8 417 K 8.72x72 AF2 AF2
C-term 418 Y - AF2 AF2
C-term 419 R - AF2 AF2
C-term 420 H - AF2 AF2
C-term 421 P - AF2 AF2
C-term 422 S - AF2 AF2
C-term 423 G - AF2 AF2
C-term 424 G - AF2 AF2
C-term 425 S - AF2 AF2
C-term 426 N - AF2 AF2
C-term 427 G - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 K 330 - G.h4s6 G 353 G.h4s6.09
Hydrophobic ICL3 K 330 - G.h4s6 G 353 G.h4s6.09
Van-der-waals ICL3 K 330 - G.h4s6 G 353 G.h4s6.09
Polar TM3 A 245 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 A 245 3x59 G.H5 R 380 G.H5.12
Polar ICL3 K 330 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 K 330 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 K 330 - G.h4s6 T 350 G.h4s6.03
Aromatic TM2 R 174 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 174 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 174 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 322 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 248 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 248 - G.S3 V 217 G.S3.01
Hydrophobic TM3 L 244 3x58 G.H5 L 388 G.H5.20
Polar TM5 K 322 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 322 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 322 5x64 G.H5 R 385 G.H5.17
Hydrophobic ICL2 F 248 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 S 247 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 S 247 - G.H5 I 383 G.H5.15
Hydrophobic TM3 L 243 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL3 D 327 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 D 327 - G.H4 L 346 G.H4.16
Polar ICL3 R 324 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 S 247 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 319 5x61 G.H5 L 393 G.H5.25
Ionic ICL3 R 329 - G.H4 D 343 G.H4.13
Polar ICL3 R 329 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 R 329 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 R 329 - G.H4 D 343 G.H4.13
Hydrophobic TM5 L 319 5x61 G.H5 L 388 G.H5.20
Hydrophobic ICL3 P 326 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 P 326 - G.S6 Y 360 G.S6.02
Polar TM6 S 342 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 342 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 342 6x41 G.H5 L 393 G.H5.25
Aromatic ICL2 F 248 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 248 - G.H5 F 376 G.H5.08
Ionic TM5 K 322 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 322 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 322 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 322 5x64 G.H5 D 381 G.H5.13
Aromatic ICL2 F 248 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 248 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 248 - G.S1 H 41 G.S1.02
Polar ICL3 D 327 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 D 327 - G.S6 C 359 G.S6.01
Hydrophobic TM3 L 240 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 240 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 248 - G.H5 R 380 G.H5.12
Hydrophobic TM5 L 319 5x61 G.H5 L 394 G.H5.26
Hydrophobic ICL3 P 326 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 P 326 - G.H5 R 385 G.H5.17
Polar TM5 K 322 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 322 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 322 5x64 G.H5 Q 384 G.H5.16
Polar TM3 L 244 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 244 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 323 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 323 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM3 Y 239 3x53 G.H5 Y 391 G.H5.23
Polar ICL3 D 327 - G.h4s6 S 349 G.h4s6.02
Hydrophobic TM3 L 243 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM6 R 338 6x37 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 248 - G.S3 F 219 G.S3.03