CT receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7TYL

RESOLUTION

3.3 Å

REFERENCE

10.1126/SCIENCE.ABM9609

PUBLICATION DATE

March 23, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

97 interactions (Click to see)

LIGANDS

Amylin rat - Agonist pubchem

ENDOGENOUS LIGANDS

β-CGRP, α-CGRP, calcitonin, calcitonin (salmon), amylin, adrenomedullin, adrenomedullin 2/intermedin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 253 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 253 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 F 253 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 253 - G.H5 I 383 G.H5.15
Aromatic TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 252 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 252 - G.H5 I 383 G.H5.15
Aromatic ICL2 F 253 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 253 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 253 - G.H5 R 380 G.H5.12
Van-der-waals TM5 E 329 5x67 G.H5 D 381 G.H5.13
Hydrophobic TM5 L 323 5x61 G.H5 L 388 G.H5.20
Polar TM5 K 326 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 326 5x64 G.H5 R 385 G.H5.17
Polar TM2 R 180 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM5 M 327 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 348 6x45 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 253 - G.S3 F 219 G.S3.03
Hydrophobic ICL2 E 255 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 255 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 I 248 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 248 3x58 G.H5 L 388 G.H5.20
Polar TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Polar TM3 V 249 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 V 249 3x59 G.H5 R 380 G.H5.12
Polar TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 248 3x58 G.H5 H 387 G.H5.19
Ionic TM5 E 329 5x67 G.H5 R 385 G.H5.17
Polar TM5 E 329 5x67 G.H5 R 385 G.H5.17
Hydrophobic TM3 L 244 3x54 G.H5 L 393 G.H5.25
Ionic TM5 K 326 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 326 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 326 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 326 5x64 G.H5 D 381 G.H5.13
Aromatic ICL2 F 253 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 253 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 253 - G.S1 H 41 G.S1.02
Polar ICL2 V 252 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 252 - G.H5 H 387 G.H5.19
Hydrophobic TM3 Y 243 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 243 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 244 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 244 3x54 G.H5 Y 391 G.H5.23
Polar H8 N 396 8x48 G.H5 E 392 G.H5.24
Ionic TM5 H 331 5x69 G.hgh4 D 323 G.hgh4.13
Polar TM5 H 331 5x69 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 H 331 5x69 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 H 331 5x69 G.hgh4 D 323 G.hgh4.13
Polar TM6 K 340 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM7 Y 391 7x57 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 323 5x61 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 323 5x61 G.H5 L 394 G.H5.26
Hydrophobic ICL2 V 252 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 252 - G.H5 Q 384 G.H5.16
Hydrophobic TM6 I 347 6x44 G.H5 L 393 G.H5.25
Polar TM3 E 240 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 351 6x48 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 252 - G.H5 R 380 G.H5.12
Hydrophobic TM3 L 247 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 247 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM6 A 344 6x41 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 253 - G.H5 C 379 G.H5.11
Van-der-waals ICL2 F 253 - G.H5 C 379 G.H5.11
Hydrophobic TM5 T 330 5x68 G.H5 R 385 G.H5.17
Aromatic ICL2 F 253 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 253 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 253 - G.H5 F 376 G.H5.08
Hydrophobic TM6 K 340 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 340 6x37 G.H5 L 394 G.H5.26