PDB
7TYL
Resolution
3.3 Å
Released
March 23, 2022
Receptor
CT
Class
B1
Species
Homo sapiens
Ligand
rat amylin
Function
Agonist
Reference
10.1126/SCIENCE.ABM9609

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Ligand Amino Acid Generic Number Segment Interaction Type
rat amylin W79 N-term aromatic (face-to-edge)
rat amylin F99 N-term hydrophobic
rat amylin W128 N-term hydrophobic
rat amylin Y131 N-term hydrophobic
rat amylin L142 1.33x33 TM1 hydrophobic
rat amylin A145 1.36x36 TM1 hydrophobic
rat amylin Y146 1.37x37 TM1 polar (hydrogen bond)
rat amylin Y146 1.37x37 TM1 Van der Waals
rat amylin L148 1.39x39 TM1 Van der Waals
rat amylin L148 1.39x39 TM1 hydrophobic
rat amylin Y149 1.40x40 TM1 Van der Waals
rat amylin Y149 1.40x40 TM1 hydrophobic
rat amylin V206 ECL1 hydrophobic
rat amylin V206 ECL1 Van der Waals
rat amylin P207 ECL1 polar (hydrogen bond with backbone)
rat amylin P207 ECL1 Van der Waals
rat amylin N208 ECL1 Van der Waals
rat amylin G209 ECL1 Van der Waals
rat amylin Q227 3.37x37 TM3 polar (hydrogen bond)
rat amylin M230 3.40x40 TM3 polar (hydrogen bond)
rat amylin Y234 3.44x44 TM3 Van der Waals
rat amylin Y234 3.44x44 TM3 hydrophobic
rat amylin L291 45.52x52 ECL2 polar (hydrogen bond with backbone)
rat amylin L291 45.52x52 ECL2 Van der Waals
rat amylin V293 ECL2 Van der Waals
rat amylin V293 ECL2 polar (hydrogen bond with backbone)
rat amylin E294 ECL2 Van der Waals
rat amylin E294 ECL2 polar (hydrogen bond with backbone)
rat amylin H296 ECL2 Van der Waals
rat amylin Y299 5.37x38 TM5 Van der Waals
rat amylin Y299 5.37x38 TM5 hydrophobic
rat amylin H302 5.40x40 TM5 polar (hydrogen bond)
rat amylin H302 5.40x40 TM5 polar (hydrogen bond)
rat amylin M306 5.44x44 TM5 Van der Waals
rat amylin M306 5.44x44 TM5 hydrophobic
rat amylin F356 6.53x53 TM6 hydrophobic
rat amylin F356 6.53x53 TM6 Van der Waals
rat amylin R362 ECL3 Van der Waals
rat amylin Y372 7.38x37 TM7 Van der Waals
rat amylin H377 7.43x42 TM7 polar (hydrogen bond)
rat amylin H377 7.43x42 TM7 Van der Waals
rat amylin H381 7.47x46 TM7 Van der Waals

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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
Helix box plot — Download: PNG | SVG V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7

GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x35 1.39x39 L148
1x36 1.40x40 Y149
TM3
3x33 3.37x37 Q227
3x36 3.40x40 M230
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x42 5.37x38 Y299
5x44 5.40x40 H302
5x48 5.44x44 M306
TM6
6x48 6.53x53 F356
TM7
7x33 7.38x37 Y372
7x38 7.43x42 H377
7x42 7.47x46 H381