OR5B21 - Gs

GPCR CLASS (FAMILY)

Class O2 (Olfactory/extra-nasal 2)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

Jan. 28, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic ICL2 V 133 - G.hns1 A 32 G.hns1.03
Van-der-waals ICL2 V 133 - G.hns1 A 32 G.hns1.03
Hydrophobic ICL2 L 129 - G.S3 V 194 G.S3.01
Hydrophobic ICL2 P 128 - G.H5 R 347 G.H5.12
Hydrophobic ICL2 L 129 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 L 129 - G.H5 I 350 G.H5.15
Hydrophobic TM6 A 236 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 A 236 6x33 G.H5 L 360 G.H5.25
Hydrophobic ICL2 L 129 - G.H5 C 346 G.H5.11
Hydrophobic ICL2 L 130 - G.S3 V 194 G.S3.01
Van-der-waals ICL2 L 130 - G.S3 V 194 G.S3.01
Polar H8 K 294 8x48 G.H5 E 359 G.H5.24
Hydrophobic H8 K 294 8x48 G.H5 E 359 G.H5.24
Van-der-waals H8 K 294 8x48 G.H5 E 359 G.H5.24
Hydrophobic TM5 M 227 5x68 G.H5 L 355 G.H5.20
Polar TM3 C 126 3x55 G.H5 R 347 G.H5.12
Van-der-waals TM3 C 126 3x55 G.H5 R 347 G.H5.12
Ionic TM6 K 235 6x32 G.H5 E 359 G.H5.24
Hydrophobic TM6 K 235 6x32 G.H5 E 359 G.H5.24
Hydrophobic TM3 I 125 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 I 125 3x54 G.H5 L 355 G.H5.20
Hydrophobic ICL2 P 128 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 128 - G.H5 I 350 G.H5.15
Hydrophobic ICL2 L 130 - G.s2s3 K 193 G.s2s3.02
Van-der-waals ICL2 L 130 - G.s2s3 K 193 G.s2s3.02
Hydrophobic ICL2 L 129 - G.H5 R 347 G.H5.12
Hydrophobic TM5 T 223 5x64 G.H5 Q 351 G.H5.16
Van-der-waals TM5 T 223 5x64 G.H5 Q 351 G.H5.16
Hydrophobic TM3 R 121 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 129 - G.S3 F 196 G.S3.03
Hydrophobic TM5 I 220 5x61 G.H5 L 360 G.H5.25
Hydrophobic TM6 K 235 6x32 G.H5 L 361 G.H5.26
Van-der-waals TM6 K 235 6x32 G.H5 L 361 G.H5.26
Hydrophobic TM3 I 125 3x54 G.H5 H 354 G.H5.19
Polar ICL2 P 128 - G.H5 H 354 G.H5.19
Hydrophobic ICL2 P 128 - G.H5 H 354 G.H5.19
Van-der-waals ICL2 P 128 - G.H5 H 354 G.H5.19
Hydrophobic ICL2 P 128 - G.H5 Q 351 G.H5.16
Hydrophobic TM5 T 223 5x64 G.H5 L 355 G.H5.20
Aromatic ICL2 Y 131 - G.H5 H 354 G.H5.19
Hydrophobic ICL2 Y 131 - G.H5 H 354 G.H5.19
Hydrophobic ICL2 L 129 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 L 129 - G.H5 F 343 G.H5.08
Polar ICL2 Y 131 - G.H5 Y 358 G.H5.23
Van-der-waals ICL2 Y 131 - G.H5 Y 358 G.H5.23
Polar TM3 A 124 3x53 G.H5 H 354 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 H 354 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 H 354 G.H5.19
Polar ICL2 T 132 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 T 132 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 T 132 - G.hns1 R 31 G.hns1.02
Polar TM6 T 239 6x36 G.H5 E 359 G.H5.24
Hydrophobic TM6 T 239 6x36 G.H5 E 359 G.H5.24
Van-der-waals TM6 T 239 6x36 G.H5 E 359 G.H5.24
Hydrophobic TM3 A 124 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 A 124 3x53 G.H5 Y 358 G.H5.23
Hydrophobic TM2 M 58 2x39 G.H5 Y 358 G.H5.23
Polar ICL2 L 129 - G.S1 H 34 G.S1.02
Hydrophobic ICL2 L 129 - G.S1 H 34 G.S1.02
Van-der-waals ICL2 L 129 - G.S1 H 34 G.S1.02
Polar TM3 I 125 3x54 G.H5 Q 351 G.H5.16
Hydrophobic TM3 I 125 3x54 G.H5 Q 351 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 Q 351 G.H5.16
Hydrophobic TM6 C 240 6x37 G.H5 L 360 G.H5.25
Hydrophobic H8 N 293 8x47 G.H5 E 359 G.H5.24
Van-der-waals H8 N 293 8x47 G.H5 E 359 G.H5.24
Hydrophobic TM3 I 125 3x54 G.H5 L 360 G.H5.25
Polar TM3 D 120 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 D 120 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM6 T 239 6x36 G.H5 L 360 G.H5.25
Hydrophobic TM3 R 121 3x50 G.H5 L 360 G.H5.25