GnRH1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Sus scrofa

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9U4W

RESOLUTION

3.2 Å

REFERENCE

10.1073/PNAS.2500112122

PUBLICATION DATE

June 11, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

73 interactions (Click to see)

LIGANDS

CHEMBL266314 - Agonist chembl_ligand pubchem pubchem drugbank pubchem chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 234 5x61 G.H5 L 358 G.H5.25
Van-der-waals TM5 I 234 5x61 G.H5 L 358 G.H5.25
Polar ICL2 N 152 - G.HN R 32 G.HN.50
Van-der-waals ICL2 N 152 - G.HN R 32 G.HN.50
Polar TM3 D 138 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 138 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 138 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM2 M 76 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 M 76 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM6 A 261 6x29 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 261 6x29 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 146 34x50 G.H5 L 349 G.H5.16
Van-der-waals ICL2 P 146 34x50 G.H5 L 349 G.H5.16
Hydrophobic TM3 A 142 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 N 352 G.H5.19
Polar ICL2 S 151 - G.HN R 32 G.HN.50
Hydrophobic ICL2 S 151 - G.HN R 32 G.HN.50
Hydrophobic TM6 I 258 6x26 G.H5 L 349 G.H5.16
Hydrophobic TM5 L 238 5x65 G.H5 L 358 G.H5.25
Polar C-term L 328 - G.H5 N 357 G.H5.24
Hydrophobic C-term L 328 - G.H5 N 357 G.H5.24
Van-der-waals C-term L 328 - G.H5 N 357 G.H5.24
Hydrophobic TM6 I 258 6x26 G.H5 L 353 G.H5.20
Hydrophobic TM3 A 142 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 142 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM6 M 268 6x36 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 146 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 146 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM3 R 139 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 143 3x54 G.H5 N 352 G.H5.19
Hydrophobic ICL2 P 146 34x50 G.H5 N 352 G.H5.19
Van-der-waals ICL2 P 146 34x50 G.H5 N 352 G.H5.19
Hydrophobic ICL2 L 147 34x51 G.HN L 34 G.HN.52
Van-der-waals ICL2 L 147 34x51 G.HN L 34 G.HN.52
Hydrophobic TM6 A 261 6x29 G.H5 L 353 G.H5.20
Van-der-waals TM6 A 261 6x29 G.H5 L 353 G.H5.20
Hydrophobic TM3 I 143 3x54 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 147 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 147 34x51 G.H5 F 341 G.H5.08
Hydrophobic TM3 I 143 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM3 R 139 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 139 3x50 G.H5 L 358 G.H5.25
Polar ICL2 S 151 - G.HN R 31 G.HN.49
Van-der-waals ICL2 S 151 - G.HN R 31 G.HN.49
Polar TM6 R 264 6x32 G.H5 N 357 G.H5.24
Van-der-waals TM6 R 264 6x32 G.H5 N 357 G.H5.24
Hydrophobic ICL2 L 147 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 147 34x51 G.H5 I 348 G.H5.15
Hydrophobic ICL2 L 147 34x51 G.S2 V 192 G.S2.04
Van-der-waals ICL2 L 147 34x51 G.S2 V 192 G.S2.04
Hydrophobic TM6 T 265 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 T 265 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM5 V 241 5x68 G.H5 L 349 G.H5.16