Other - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Petromyzon marinus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9VMG

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41421-025-00839-4

PUBLICATION DATE

May 13, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

30 interactions (Click to see)

LIGANDS

spermine - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 137 - G.H5 R 232 G.H5.12
Van-der-waals ICL2 P 137 - G.H5 R 232 G.H5.12
Hydrophobic ICL2 L 138 - G.S3 F 81 G.S3.03
Van-der-waals ICL2 L 138 - G.S3 F 81 G.S3.03
Hydrophobic ICL2 L 138 - G.S3 V 79 G.S3.01
Hydrophobic ICL2 L 138 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 L 138 - G.H5 F 228 G.H5.08
Ionic H8 R 312 8x48 G.H5 E 244 G.H5.24
Hydrophobic H8 R 312 8x48 G.H5 E 244 G.H5.24
Polar TM3 A 133 3x53 G.H5 H 239 G.H5.19
Hydrophobic TM3 A 133 3x53 G.H5 H 239 G.H5.19
Van-der-waals TM3 A 133 3x53 G.H5 H 239 G.H5.19
Hydrophobic TM7 F 310 7x56 G.H5 Y 243 G.H5.23
Van-der-waals TM7 F 310 7x56 G.H5 Y 243 G.H5.23
Hydrophobic TM3 I 134 3x54 G.H5 L 245 G.H5.25
Polar ICL2 L 138 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 138 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 138 - G.S1 H 41 G.S1.02
Polar TM7 N 311 7x57 G.H5 Q 242 G.H5.22
Van-der-waals TM7 N 311 7x57 G.H5 Q 242 G.H5.22
Hydrophobic TM5 A 223 5x66 G.H5 L 240 G.H5.20
Van-der-waals TM5 A 223 5x66 G.H5 L 240 G.H5.20
Hydrophobic ICL2 P 137 - G.H2 I 235 G.H2.08
Van-der-waals ICL2 P 137 - G.H2 I 235 G.H2.08
Hydrophobic TM3 I 134 3x54 G.H5 Y 243 G.H5.23
Hydrophobic TM3 I 134 3x54 G.H5 H 239 G.H5.19
Hydrophobic ICL2 Q 142 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 Q 142 - G.hns1 A 39 G.hns1.03
Hydrophobic TM7 F 310 7x56 G.H5 E 244 G.H5.24
Hydrophobic H8 P 313 8x49 G.H5 Q 242 G.H5.22
Van-der-waals H8 P 313 8x49 G.H5 Q 242 G.H5.22
Hydrophobic TM3 I 134 3x54 G.H5 L 240 G.H5.20
Hydrophobic TM5 I 230 5x73 G.H5 R 237 G.H5.17
Van-der-waals TM5 I 230 5x73 G.H5 R 237 G.H5.17
Hydrophobic TM5 Q 226 5x69 G.H5 L 246 G.H5.26
Polar TM3 I 134 3x54 G.H5 Q 236 G.H5.16
Hydrophobic TM3 I 134 3x54 G.H5 Q 236 G.H5.16
Van-der-waals TM3 I 134 3x54 G.H5 Q 236 G.H5.16
Polar TM6 T 255 6x36 G.H5 E 244 G.H5.24
Hydrophobic TM6 T 255 6x36 G.H5 E 244 G.H5.24
Van-der-waals TM6 T 255 6x36 G.H5 E 244 G.H5.24
Hydrophobic TM5 A 223 5x66 G.H5 L 245 G.H5.25
Van-der-waals TM5 A 223 5x66 G.H5 L 245 G.H5.25
Hydrophobic ICL2 L 138 - G.H2 I 235 G.H2.08
Van-der-waals ICL2 L 138 - G.H2 I 235 G.H2.08
Polar TM5 Q 226 5x69 G.H5 R 237 G.H5.17
Hydrophobic TM5 Q 226 5x69 G.H5 R 237 G.H5.17
Van-der-waals TM5 Q 226 5x69 G.H5 R 237 G.H5.17
Hydrophobic ICL2 R 139 - G.H5 F 228 G.H5.08
Polar TM6 S 251 6x32 G.H5 E 244 G.H5.24
Hydrophobic TM7 N 311 7x57 G.H5 Y 243 G.H5.23
Van-der-waals TM7 N 311 7x57 G.H5 Y 243 G.H5.23
Hydrophobic TM5 I 219 5x62 G.H5 L 245 G.H5.25
Van-der-waals TM5 I 219 5x62 G.H5 L 245 G.H5.25
Hydrophobic ICL2 L 138 - G.H5 C 231 G.H5.11
Polar TM3 S 135 3x55 G.H5 Q 236 G.H5.16
Polar TM5 Q 226 5x69 G.H5 D 233 G.H5.13
Hydrophobic TM5 I 230 5x73 G.h4s6 Y 210 G.h4s6.20
Hydrophobic ICL2 R 139 - G.hns1 A 39 G.hns1.03
Polar TM5 S 232 5x75 G.hgh4 D 175 G.hgh4.13
Van-der-waals TM5 S 232 5x75 G.hgh4 D 175 G.hgh4.13
Ionic ICL2 R 139 - G.s2s3 D 77 G.s2s3.01
Polar ICL2 R 139 - G.s2s3 D 77 G.s2s3.01
Van-der-waals ICL2 R 139 - G.s2s3 D 77 G.s2s3.01
Ionic TM5 K 229 5x72 G.H5 D 233 G.H5.13
Polar TM5 K 229 5x72 G.H5 D 233 G.H5.13
Van-der-waals TM5 K 229 5x72 G.H5 D 233 G.H5.13
Hydrophobic TM6 T 255 6x36 G.H5 L 245 G.H5.25
Van-der-waals TM6 T 255 6x36 G.H5 L 245 G.H5.25
Van-der-waals TM5 K 229 5x72 G.H5 R 237 G.H5.17
Hydrophobic ICL2 P 137 - G.H5 Q 236 G.H5.16
Polar TM5 Q 226 5x69 G.H5 Q 236 G.H5.16
Hydrophobic ICL2 E 141 - G.hns1 A 38 G.hns1.02
Van-der-waals ICL2 E 141 - G.hns1 A 38 G.hns1.02
Hydrophobic ICL2 L 138 - G.H5 R 232 G.H5.12
Hydrophobic TM5 Q 226 5x69 G.H5 L 240 G.H5.20
Van-der-waals TM5 Q 226 5x69 G.H5 L 240 G.H5.20
Polar ICL3 V 235 - G.h4s6 T 202 G.h4s6.03
Hydrophobic ICL3 V 235 - G.h4s6 T 202 G.h4s6.03
Van-der-waals ICL3 V 235 - G.h4s6 T 202 G.h4s6.03
Polar TM6 S 251 6x32 G.H5 L 245 G.H5.25
Van-der-waals TM6 S 251 6x32 G.H5 L 245 G.H5.25
Hydrophobic ICL3 V 235 - H.HF L 198 H.HF.05
Polar TM6 S 251 6x32 G.H5 L 246 G.H5.26
Van-der-waals TM6 S 251 6x32 G.H5 L 246 G.H5.26
Ionic ICL3 R 247 - G.H5 E 244 G.H5.24
Polar ICL3 R 247 - G.H5 E 244 G.H5.24
Van-der-waals ICL3 R 247 - G.H5 E 244 G.H5.24
Hydrophobic ICL2 R 139 - G.S3 V 79 G.S3.01
Hydrophobic TM5 I 230 5x73 G.H5 L 246 G.H5.26
Van-der-waals TM5 I 230 5x73 G.H5 L 246 G.H5.26
Hydrophobic TM6 M 256 6x37 G.H5 L 245 G.H5.25
Van-der-waals TM6 M 256 6x37 G.H5 L 245 G.H5.25
Aromatic TM3 R 130 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 Y 243 G.H5.23
Polar H8 R 312 8x48 G.H5 R 241 G.H5.21
Hydrophobic H8 R 312 8x48 G.H5 R 241 G.H5.21
Van-der-waals H8 R 312 8x48 G.H5 R 241 G.H5.21
Ionic H8 R 315 8x51 G.H5 E 244 G.H5.24
Polar H8 R 315 8x51 G.H5 E 244 G.H5.24
Hydrophobic H8 R 315 8x51 G.H5 E 244 G.H5.24
Van-der-waals H8 R 315 8x51 G.H5 E 244 G.H5.24
Polar H8 R 312 8x48 G.H5 Q 242 G.H5.22
Hydrophobic H8 R 312 8x48 G.H5 Q 242 G.H5.22
Van-der-waals H8 R 312 8x48 G.H5 Q 242 G.H5.22