δ receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9PPW

RESOLUTION

3.3 Å

REFERENCE

10.1126/SCIADV.AEB6737

PUBLICATION DATE

March 4, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

32 interactions (Click to see)

LIGANDS

naltrindole - Antagonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

[Met]enkephalin (Human), dynorphin A (Human), dynorphin A-(1-8) (Human), dynorphin A-(1-13) (Human), β-endorphin (Mouse), endomorphin-1 (Human), β-endorphin (Rat), dynorphin B (Human), β-endorphin (Human), α-neoendorphin (Human), [Leu]enkephalin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 150 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 150 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 153 - G.H5 I 343 G.H5.15
Hydrophobic TM6 S 255 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 S 255 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL3 R 244 - G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 E 323 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 323 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 146 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 149 3x53 G.H5 C 351 G.H5.23
Polar H8 E 323 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 E 323 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 323 8x48 G.H5 G 352 G.H5.24
Polar ICL2 L 157 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 157 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 157 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 240 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 M 236 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 153 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 V 154 - G.S3 L 194 G.S3.01
Hydrophobic H8 N 324 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 N 324 8x49 G.H5 G 352 G.H5.24
Polar ICL3 R 244 - G.H5 D 341 G.H5.13
Hydrophobic TM5 M 236 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 M 236 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 154 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 V 154 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 L 157 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 157 - G.S3 L 194 G.S3.01
Polar TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 146 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 154 - G.H5 F 336 G.H5.08
Polar TM3 A 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 149 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 V 243 5x68 G.H5 I 344 G.H5.16
Polar ICL2 R 160 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 160 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 160 - G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 246 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 L 246 - G.H5 F 354 G.H5.26
Hydrophobic TM3 V 150 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 150 3x54 G.H5 I 344 G.H5.16
Polar ICL2 R 160 - G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 245 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 153 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 153 - G.H5 I 344 G.H5.16
Polar TM6 R 258 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 258 6x32 G.H5 F 354 G.H5.26
Hydrophobic H8 E 323 8x48 G.H5 L 353 G.H5.25