Refined structure (9K1C) of Gi1 - FFA1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2025-03-19

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.9%), 135 from model (38.1%)
Residue sidechains - 208 from structure (58.8%), 146 from model (41.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure AF2
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 Structure AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure AF2
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 279 from structure (93.0%), 21 from model (7.0%)
Residue sidechains - 253 from structure (84.3%), 47 from model (15.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - Structure AF2
N-term 2 D - Structure AF2
N-term 3 L - Structure AF2
TM1 4 P 1.31x31 Structure Structure
TM1 5 P 1.32x32 Structure Structure
TM1 6 Q 1.33x33 Structure Structure
TM1 7 L 1.34x34 Structure Structure
TM1 8 S 1.35x35 Structure Structure
TM1 9 F 1.36x36 Structure Structure
TM1 10 G 1.37x37 Structure Structure
TM1 11 L 1.38x38 Structure Structure
TM1 12 Y 1.39x39 Structure Structure
TM1 13 V 1.40x40 Structure Structure
TM1 14 A 1.41x41 Structure Structure
TM1 15 A 1.42x42 Structure Structure
TM1 16 F 1.43x43 Structure Structure
TM1 17 A 1.44x44 Structure Structure
TM1 18 L 1.45x45 Structure Structure
TM1 19 G 1.46x46 Structure Structure
TM1 20 F 1.47x47 Structure Structure
TM1 21 P 1.48x48 Structure Structure
TM1 22 L 1.49x49 Structure Structure
TM1 23 N 1.50x50 Structure Structure
TM1 24 V 1.51x51 Structure Structure
TM1 25 L 1.52x52 Structure Structure
TM1 26 A 1.53x53 Structure Structure
TM1 27 I 1.54x54 Structure Structure
TM1 28 R 1.55x55 Structure AF2
TM1 29 G 1.56x56 Structure Structure
TM1 30 A 1.57x57 Structure Structure
TM1 31 T 1.58x58 Structure Structure
TM1 32 A 1.59x59 Structure Structure
TM1 33 H 1.60x60 Structure Structure
TM1 34 A 1.61x61 Structure Structure
TM1 35 R 1.62x62 Structure AF2
TM1 36 L 1.63x63 Structure Structure
TM1 37 R 1.64x64 Structure Structure
ICL1 38 L - Structure Structure
TM2 39 T 2.37x37 Structure Structure
TM2 40 P 2.38x38 Structure Structure
TM2 41 S 2.39x39 Structure Structure
TM2 42 L 2.40x40 Structure Structure
TM2 43 V 2.41x41 Structure Structure
TM2 44 Y 2.42x42 Structure Structure
TM2 45 A 2.43x43 Structure Structure
TM2 46 L 2.44x44 Structure Structure
TM2 47 N 2.45x45 Structure Structure
TM2 48 L 2.46x46 Structure Structure
TM2 49 G 2.47x47 Structure Structure
TM2 50 C 2.48x48 Structure Structure
TM2 51 S 2.49x49 Structure Structure
TM2 52 D 2.50x50 Structure Structure
TM2 53 L 2.51x51 Structure Structure
TM2 54 L 2.52x52 Structure Structure
TM2 55 L 2.53x53 Structure Structure
TM2 56 T 2.54x54 Structure Structure
TM2 57 V 2.55x55 Structure Structure
TM2 58 S 2.56x56 Structure Structure
TM2 59 L 2.57x57 Structure Structure
TM2 60 P 2.58x58 Structure Structure
TM2 61 L 2.59x59 Structure Structure
TM2 62 K 2.60x60 Structure Structure
TM2 63 A 2.61x61 Structure Structure
TM2 64 V 2.62x62 Structure Structure
TM2 65 E 2.63x63 Structure AF2
TM2 66 A 2.64x64 Structure Structure
TM2 67 L 2.65x65 Structure AF2
TM2 68 A 2.66x66 Structure Structure
TM2 69 S 2.67x67 Structure Structure
ECL1 70 G - Structure Structure
ECL1 71 A 23.49x49 Structure Structure
ECL1 72 W 23.50x50 Structure Structure
ECL1 73 P 23.51x51 Structure Structure
ECL1 74 L 23.52x52 Structure AF2
TM3 75 P 3.21x21 Structure Structure
TM3 76 A 3.22x22 Structure Structure
TM3 77 S 3.23x23 Structure Structure
TM3 78 L 3.24x24 Structure Structure
TM3 79 C 3.25x25 Structure Structure
TM3 80 P 3.26x26 Structure Structure
TM3 81 V 3.27x27 Structure Structure
TM3 82 F 3.28x28 Structure Structure
TM3 83 A 3.29x29 Structure Structure
TM3 84 V 3.30x30 Structure Structure
TM3 85 A 3.31x31 Structure Structure
TM3 86 H 3.32x32 Structure Structure
TM3 87 F 3.33x33 Structure Structure
TM3 88 F 3.34x34 Structure Structure
TM3 89 P 3.35x35 Structure Structure
TM3 90 L 3.36x36 Structure Structure
TM3 91 Y 3.37x37 Structure Structure
TM3 92 A 3.38x38 Structure Structure
TM3 93 G 3.39x39 Structure Structure
TM3 94 G 3.40x40 Structure Structure
TM3 95 G 3.41x41 Structure Structure
TM3 96 F 3.42x42 Structure Structure
TM3 97 L 3.43x43 Structure Structure
TM3 98 A 3.44x44 Structure Structure
TM3 99 A 3.45x45 Structure Structure
TM3 100 L 3.46x46 Structure Structure
TM3 101 S 3.47x47 Structure Structure
TM3 102 A 3.48x48 Structure Structure
TM3 103 G 3.49x49 Structure Structure
TM3 104 R 3.50x50 Structure Structure
TM3 105 Y 3.51x51 Structure Structure
TM3 106 L 3.52x52 Structure Structure
TM3 107 G 3.53x53 Structure Structure
TM3 108 A 3.54x54 Structure Structure
TM3 109 A 3.55x55 Structure Structure
TM3 110 F 3.56x56 Structure Structure
ICL2 111 P 34.50x50 Structure Structure
ICL2 112 L 34.51x51 Structure Structure
ICL2 113 G 34.52x52 Structure Structure
ICL2 114 Y 34.53x53 Structure Structure
ICL2 115 Q 34.54x54 Structure Structure
ICL2 116 A 34.55x55 Structure Structure
ICL2 117 F 34.56x56 Structure Structure
ICL2 118 R 34.57x57 Structure Structure
TM4 119 R 4.38x38 Structure Structure
TM4 120 P 4.39x39 Structure Structure
TM4 121 C 4.40x40 Structure Structure
TM4 122 Y 4.41x41 Structure Structure
TM4 123 S 4.42x42 Structure Structure
TM4 124 W 4.43x43 Structure Structure
TM4 125 G 4.44x44 Structure Structure
TM4 126 V 4.45x45 Structure Structure
TM4 127 C 4.46x46 Structure Structure
TM4 128 A 4.47x47 Structure Structure
TM4 129 A 4.48x48 Structure Structure
TM4 130 I 4.49x49 Structure Structure
TM4 131 W 4.50x50 Structure Structure
TM4 132 A 4.51x51 Structure Structure
TM4 133 L 4.52x52 Structure Structure
TM4 134 V 4.53x53 Structure Structure
TM4 135 L 4.54x54 Structure Structure
TM4 136 C 4.55x55 Structure Structure
TM4 137 H 4.56x56 Structure Structure
TM4 138 L 4.57x57 Structure Structure
TM4 139 G 4.58x58 Structure Structure
TM4 140 L 4.59x59 Structure Structure
TM4 141 V 4.60x60 Structure Structure
TM4 142 F 4.61x61 Structure Structure
TM4 143 G 4.62x62 Structure Structure
TM4 144 L 4.63x63 Structure Structure
TM4 145 E 4.64x64 Structure AF2
TM4 146 A 4.65x65 Structure Structure
ECL2 147 P - Structure Structure
ECL2 148 G - Structure Structure
ECL2 149 G - Structure Structure
ECL2 150 W - Structure AF2
ECL2 151 L - Structure AF2
ECL2 152 D - Structure AF2
ECL2 153 H - Structure AF2
ECL2 154 S - Structure Structure
ECL2 155 N - Structure AF2
ECL2 156 T - Structure AF2
ECL2 157 S - Structure Structure
ECL2 158 L - Structure AF2
ECL2 159 G - Structure Structure
ECL2 160 I - Structure AF2
ECL2 161 N - Structure AF2
ECL2 162 T - Structure AF2
ECL2 163 P - Structure Structure
ECL2 164 V - Structure AF2
ECL2 165 N - Structure AF2
ECL2 166 G - Structure Structure
ECL2 167 S - Structure Structure
ECL2 168 P - Structure Structure
ECL2 169 V - Structure AF2
ECL2 170 C 45.50x50 Structure Structure
ECL2 171 L 45.51x51 Structure AF2
ECL2 172 E 45.52x52 Structure AF2
ECL2 173 A - Structure Structure
ECL2 174 W - Structure Structure
TM5 175 D 5.31x32 Structure AF2
TM5 176 P 5.32x33 Structure Structure
TM5 177 A 5.33x34 Structure Structure
TM5 178 S 5.34x35 Structure Structure
TM5 179 A 5.35x36 Structure Structure
TM5 180 G 5.36x37 Structure Structure
TM5 181 P 5.37x38 Structure Structure
TM5 182 A 5.38x39 Structure Structure
TM5 183 R 5.39x40 Structure Structure
TM5 184 F 5.40x41 Structure Structure
TM5 185 S 5.41x42 Structure Structure
TM5 186 L 5.42x43 Structure Structure
TM5 187 S 5.43x44 Structure Structure
TM5 188 L 5.44x45 Structure Structure
TM5 189 L 5.45x46 Structure Structure
TM5 190 L 5.46x461 Structure Structure
TM5 191 F 5.47x47 Structure Structure
TM5 192 F 5.48x48 Structure Structure
TM5 193 L 5.49x49 Structure Structure
TM5 194 P 5.50x50 Structure Structure
TM5 195 L 5.51x51 Structure Structure
TM5 196 A 5.52x52 Structure Structure
TM5 197 I 5.53x53 Structure Structure
TM5 198 T 5.54x54 Structure Structure
TM5 199 A 5.55x55 Structure Structure
TM5 200 F 5.56x56 Structure Structure
TM5 201 C 5.57x57 Structure Structure
TM5 202 Y 5.58x58 Structure Structure
TM5 203 V 5.59x59 Structure Structure
TM5 204 G 5.60x60 Structure Structure
TM5 205 C 5.61x61 Structure Structure
TM5 206 L 5.62x62 Structure Structure
TM5 207 R 5.63x63 Structure Structure
TM5 208 A 5.64x64 Structure Structure
TM5 209 L 5.65x65 Structure Structure
TM5 210 A 5.66x66 Structure Structure
TM5 211 R 5.67x67 Structure Structure
ICL3 212 S - Structure Structure
ICL3 213 G - Structure Structure
ICL3 214 L - Structure Structure
ICL3 215 T - Structure Structure
ICL3 216 H - Structure Structure
TM6 217 R 6.28x29 Structure Structure
TM6 218 R 6.29x30 Structure Structure
TM6 219 K 6.30x31 Structure Structure
TM6 220 L 6.31x32 Structure Structure
TM6 221 R 6.32x33 Structure Structure
TM6 222 A 6.33x34 Structure Structure
TM6 223 A 6.34x35 Structure Structure
TM6 224 W 6.35x36 Structure Structure
TM6 225 V 6.36x37 Structure Structure
TM6 226 A 6.37x38 Structure Structure
TM6 227 G 6.38x39 Structure Structure
TM6 228 G 6.39x40 Structure Structure
TM6 229 A 6.40x41 Structure Structure
TM6 230 L 6.41x42 Structure Structure
TM6 231 L 6.42x43 Structure Structure
TM6 232 T 6.43x44 Structure Structure
TM6 233 L 6.44x45 Structure Structure
TM6 234 L 6.45x46 Structure Structure
TM6 235 L 6.46x461 Structure Structure
TM6 236 C 6.47x47 Structure Structure
TM6 237 V 6.48x48 Structure Structure
TM6 238 G 6.49x49 Structure Structure
TM6 239 P 6.50x50 Structure Structure
TM6 240 Y 6.51x51 Structure Structure
TM6 241 N 6.52x52 Structure Structure
TM6 242 A 6.53x53 Structure Structure
TM6 243 S 6.54x54 Structure Structure
TM6 244 N 6.55x55 Structure Structure
TM6 245 V 6.56x56 Structure Structure
TM6 246 A 6.57x57 Structure Structure
TM6 247 S 6.58x58 Structure Structure
TM6 248 F 6.59x59 Structure Structure
TM6 249 L 6.60x60 Structure Structure
TM6 250 Y 6.61x61 Structure Structure
ECL3 251 P - Structure Structure
ECL3 252 N - Structure Structure
ECL3 253 L - Structure Structure
ECL3 254 G - Structure Structure
TM7 255 G 7.32x31 Structure Structure
TM7 256 S 7.33x32 Structure Structure
TM7 257 W 7.34x33 Structure Structure
TM7 258 R 7.35x34 Structure Structure
TM7 259 K 7.36x35 Structure AF2
TM7 260 L 7.37x36 Structure Structure
TM7 261 G 7.38x37 Structure Structure
TM7 262 L 7.39x38 Structure Structure
TM7 263 I 7.40x39 Structure Structure
TM7 264 T 7.41x40 Structure Structure
TM7 265 G 7.42x41 Structure Structure
TM7 266 A 7.43x42 Structure Structure
TM7 267 W 7.44x43 Structure Structure
TM7 268 S 7.45x45 Structure Structure
TM7 269 V 7.46x46 Structure Structure
TM7 270 V 7.47x47 Structure Structure
TM7 271 L 7.48x48 Structure Structure
TM7 272 N 7.49x49 Structure Structure
TM7 273 P 7.50x50 Structure Structure
TM7 274 L 7.51x51 Structure Structure
TM7 275 V 7.52x52 Structure Structure
TM7 276 T 7.53x53 Structure Structure
TM7 277 G 7.54x54 Structure Structure
TM7 278 Y 7.55x55 Structure Structure
TM7 279 L 7.56x56 Structure Structure
H8 280 G 8.47x47 AF2 AF2
H8 281 R 8.48x48 AF2 AF2
H8 282 G 8.49x49 AF2 AF2
H8 283 P 8.50x50 AF2 AF2
H8 284 G 8.51x51 AF2 AF2
H8 285 L 8.52x52 AF2 AF2
H8 286 K 8.53x53 AF2 AF2
H8 287 T 8.54x54 AF2 AF2
H8 288 V 8.55x55 AF2 AF2
H8 289 C 8.56x56 AF2 AF2
H8 290 A 8.57x57 AF2 AF2
H8 291 A 8.58x58 AF2 AF2
H8 292 R 8.59x59 AF2 AF2
H8 293 T 8.60x60 AF2 AF2
H8 294 Q 8.61x61 AF2 AF2
C-term 295 G - AF2 AF2
C-term 296 G - AF2 AF2
C-term 297 K - AF2 AF2
C-term 298 S - AF2 AF2
C-term 299 Q - AF2 AF2
C-term 300 K - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 111 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 111 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM5 L 209 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 209 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 214 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 Q 115 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 115 34x54 G.H5 I 343 G.H5.15
Polar ICL3 T 215 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 104 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 111 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 111 34x50 G.H5 I 344 G.H5.16
Ionic TM4 R 119 4x38 G.HN E 28 G.HN.52
Polar TM4 R 119 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 R 119 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 119 4x38 G.HN E 28 G.HN.52
Polar ICL3 T 215 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 T 215 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 T 215 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 L 214 - G.H5 K 345 G.H5.17
Polar TM2 S 41 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 41 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 41 2x39 G.H5 C 351 G.H5.23
Ionic TM1 R 37 1x64 G.H5 D 350 G.H5.22
Polar TM1 R 37 1x64 G.H5 D 350 G.H5.22
Van-der-waals TM1 R 37 1x64 G.H5 D 350 G.H5.22
Polar TM3 G 107 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 G 107 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 G 107 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 225 6x37 G.H5 L 353 G.H5.25
Polar TM3 R 104 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 104 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 C 205 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 114 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 114 34x53 G.H5 N 347 G.H5.19
Polar ICL2 Q 115 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 115 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 115 34x54 G.hns1 R 32 G.hns1.03
Ionic TM6 R 218 6x30 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 218 6x30 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 218 6x30 G.h4s6 E 318 G.h4s6.12
Polar ICL2 Q 115 34x54 G.hns1 A 31 G.hns1.02
Polar ICL3 G 213 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 R 221 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 222 6x34 G.H5 L 348 G.H5.20
Polar ICL2 P 111 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 112 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM2 P 40 2x38 G.H5 D 350 G.H5.22
Van-der-waals TM2 P 40 2x38 G.H5 D 350 G.H5.22
Hydrophobic ICL2 L 112 34x51 G.S3 L 194 G.S3.01
Polar TM6 A 222 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 222 6x34 G.H5 L 353 G.H5.25
Polar ICL3 G 213 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 G 213 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 G 213 - G.H5 D 341 G.H5.13
Hydrophobic TM2 T 39 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 39 2x37 G.H5 D 350 G.H5.22
Polar ICL3 S 212 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 111 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 111 34x50 G.H5 I 343 G.H5.15
Ionic ICL2 R 118 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 118 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 118 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 118 34x57 G.H5 D 350 G.H5.22
Polar ICL2 Y 114 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 114 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 114 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 214 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 214 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 A 108 3x54 G.H5 L 348 G.H5.20
Polar TM6 R 218 6x30 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM6 R 218 6x30 G.h4s6 T 316 G.h4s6.10
Van-der-waals TM6 R 218 6x30 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM6 R 218 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 218 6x30 G.H5 K 345 G.H5.17
Hydrophobic ICL2 L 112 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM3 G 103 3x49 G.H5 C 351 G.H5.23
Polar ICL3 L 214 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 L 214 - G.H5 D 341 G.H5.13