FFA1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9K1C

RESOLUTION

3.2 Å

REFERENCE

10.1016/J.CELREP.2024.115024

PUBLICATION DATE

Dec. 11, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

29 interactions (Click to see)

LIGANDS

docosahexaenoic acid - Agonist pubchem gtoplig chembl_ligand drug_central drugbank pubchem

PHYSIOLOGICAL LIGANDS

oleic acid, docosahexaenoic acid, α-linolenic acid, myristic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 C 205 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 218 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 218 6x30 G.H5 K 345 G.H5.17
Hydrophobic ICL2 Q 115 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 115 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM5 L 209 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 209 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 104 3x50 G.H5 L 353 G.H5.25
Polar ICL3 G 213 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 A 222 6x34 G.H5 L 348 G.H5.20
Polar TM6 T 215 6x27 G.h4s6 E 318 G.h4s6.12
Polar C-term Y 278 - G.H5 G 352 G.H5.24
Hydrophobic C-term Y 278 - G.H5 G 352 G.H5.24
Van-der-waals C-term Y 278 - G.H5 G 352 G.H5.24
Ionic TM4 R 119 4x38 G.HN E 28 G.HN.52
Polar TM4 R 119 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 R 119 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 119 4x38 G.HN E 28 G.HN.52
Polar TM6 A 222 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 222 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM2 P 40 2x38 G.H5 D 350 G.H5.22
Van-der-waals TM2 P 40 2x38 G.H5 D 350 G.H5.22
Hydrophobic ICL2 L 112 34x51 G.H5 F 336 G.H5.08
Polar ICL3 G 213 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 G 213 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 G 213 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 L 214 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 111 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 111 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 112 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 R 221 6x33 G.H5 F 354 G.H5.26
Polar TM5 S 212 5x68 G.H5 D 341 G.H5.13
Polar C-term Y 278 - G.H5 C 351 G.H5.23
Ionic ICL2 R 118 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 118 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 118 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 118 34x57 G.H5 D 350 G.H5.22
Polar TM6 T 215 6x27 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 T 215 6x27 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 T 215 6x27 G.h4s6 D 315 G.h4s6.09
Polar TM3 R 104 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 104 3x50 G.H5 C 351 G.H5.23
Ionic TM6 R 218 6x30 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 218 6x30 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 218 6x30 G.h4s6 E 318 G.h4s6.12
Polar ICL3 L 214 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 L 214 - G.H5 D 341 G.H5.13
Polar ICL2 Q 115 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 115 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 115 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 112 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 V 225 6x37 G.H5 L 353 G.H5.25
Ionic TM1 R 37 1x64 G.H5 D 350 G.H5.22
Polar TM1 R 37 1x64 G.H5 D 350 G.H5.22
Van-der-waals TM1 R 37 1x64 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 111 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 111 34x50 G.H5 I 343 G.H5.15
Polar TM3 G 107 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 G 107 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 G 107 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 G 103 3x49 G.H5 C 351 G.H5.23
Polar ICL2 Y 114 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 114 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 114 34x53 G.H5 C 351 G.H5.23
Polar ICL2 P 111 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 214 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 Y 114 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 114 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 214 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 214 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 111 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 111 34x50 G.H5 T 340 G.H5.12
Polar TM2 S 41 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 41 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 41 2x39 G.H5 C 351 G.H5.23
Polar TM6 R 218 6x30 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM6 R 218 6x30 G.h4s6 T 316 G.h4s6.10
Van-der-waals TM6 R 218 6x30 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM3 A 108 3x54 G.H5 L 348 G.H5.20
Polar ICL2 Q 115 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM2 T 39 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 39 2x37 G.H5 D 350 G.H5.22