Refined structure (7F6I) of Gq - B2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 225 from structure (62.7%), 134 from model (37.3%)
Residue sidechains - 224 from structure (62.4%), 135 from model (37.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 AF2 AF2
G.HN 11 L G.HN.11 AF2 AF2
G.HN 12 S G.HN.30 AF2 AF2
G.HN 13 E G.HN.31 AF2 AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure Structure
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure Structure
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure Structure
G.HN 20 R G.HN.38 Structure Structure
G.HN 21 I G.HN.39 Structure Structure
G.HN 22 N G.HN.40 Structure Structure
G.HN 23 D G.HN.41 Structure Structure
G.HN 24 E G.HN.42 Structure Structure
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure Structure
G.HN 27 R G.HN.45 Structure Structure
G.HN 28 Q G.HN.46 Structure Structure
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure Structure
G.HN 31 R G.HN.49 Structure Structure
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure Structure
G.HN 34 R G.HN.52 Structure Structure
G.HN 35 D G.HN.53 Structure Structure
G.hns1 36 A G.hns1.01 Structure Structure
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure Structure
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure Structure
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure Structure
G.s1h1 48 G G.s1h1.03 Structure Structure
G.s1h1 49 E G.s1h1.04 Structure Structure
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure Structure
G.H1 56 I G.H1.05 Structure Structure
G.H1 57 K G.H1.06 Structure Structure
G.H1 58 Q G.H1.07 Structure Structure
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 Structure Structure
G.H1 62 I G.H1.11 Structure Structure
G.H1 63 H G.H1.12 Structure Structure
G.h1ha 64 G G.h1ha.01 Structure Structure
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 Structure Structure
G.hfs2 187 T G.hfs2.06 Structure Structure
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure Structure
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure Structure
G.S2 193 P G.S2.05 Structure Structure
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure Structure
G.S2 196 L G.S2.08 Structure Structure
G.s2s3 197 Q G.s2s3.01 Structure Structure
G.s2s3 198 S G.s2s3.02 Structure Structure
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure Structure
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure Structure
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure Structure
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure Structure
G.s3h2 209 Q G.s3h2.03 Structure AF2
G.H2 210 R G.H2.01 Structure Structure
G.H2 211 S G.H2.02 Structure Structure
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure Structure
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure Structure
G.h2s4 222 N G.h2s4.03 Structure Structure
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure Structure
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure Structure
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure Structure
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure Structure
G.s4h3 232 L G.s4h3.01 Structure Structure
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure Structure
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure Structure
G.s4h3 237 Q G.s4h3.06 Structure Structure
G.s4h3 238 V G.s4h3.07 Structure Structure
G.s4h3 239 L G.s4h3.08 Structure Structure
G.s4h3 240 V G.s4h3.09 Structure Structure
G.s4h3 241 E G.s4h3.10 Structure Structure
G.s4h3 242 S G.s4h3.11 Structure Structure
G.s4h3 243 D G.s4h3.12 Structure Structure
G.s4h3 244 N G.s4h3.13 Structure Structure
G.s4h3 245 E G.s4h3.14 Structure Structure
G.s4h3 246 N G.s4h3.15 Structure Structure
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure Structure
G.H3 249 E G.H3.03 Structure Structure
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure Structure
G.H3 252 K G.H3.06 Structure Structure
G.H3 253 A G.H3.07 Structure Structure
G.H3 254 L G.H3.08 Structure Structure
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure Structure
G.H3 257 T G.H3.11 Structure Structure
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure Structure
G.H3 260 T G.H3.14 Structure Structure
G.H3 261 Y G.H3.15 Structure Structure
G.H3 262 P G.H3.16 Structure Structure
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure Structure
G.h3s5 265 Q G.h3s5.01 Structure Structure
G.h3s5 266 N G.h3s5.02 Structure Structure
G.h3s5 267 S G.h3s5.03 Structure Structure
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure Structure
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure Structure
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure Structure
G.HG 284 M G.HG.09 Structure Structure
G.HG 285 Y G.HG.12 Structure Structure
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure Structure
G.HG 288 L G.HG.15 Structure Structure
G.HG 289 V G.HG.16 Structure Structure
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 Structure Structure
G.hgh4 292 F G.hgh4.02 Structure Structure
G.hgh4 293 P G.hgh4.03 Structure Structure
G.hgh4 294 E G.hgh4.04 Structure Structure
G.hgh4 295 Y G.hgh4.05 Structure Structure
G.hgh4 296 D G.hgh4.06 Structure Structure
G.hgh4 297 G G.hgh4.07 Structure Structure
G.hgh4 298 P G.hgh4.08 Structure Structure
G.H4 299 Q G.H4.01 Structure Structure
G.H4 300 R G.H4.02 Structure Structure
G.H4 301 D G.H4.03 Structure Structure
G.H4 302 A G.H4.04 Structure Structure
G.H4 303 Q G.H4.05 Structure Structure
G.H4 304 A G.H4.06 Structure Structure
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure Structure
G.H4 307 E G.H4.09 Structure Structure
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure Structure
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure Structure
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure Structure
G.h4s6 317 N G.h4s6.08 Structure Structure
G.h4s6 318 P G.h4s6.09 Structure Structure
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure Structure
G.h4s6 321 D G.h4s6.12 Structure Structure
G.h4s6 322 K G.h4s6.13 Structure Structure
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure Structure
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure Structure
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure Structure
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure Structure
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure Structure
G.H5 340 V G.H5.07 Structure Structure
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure Structure
G.H5 343 A G.H5.10 Structure Structure
G.H5 344 V G.H5.11 Structure Structure
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure Structure
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure Structure
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure Structure
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 305 from structure (85.7%), 51 from model (14.3%)
Residue sidechains - 305 from structure (85.7%), 51 from model (14.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 F - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 P - AF2 AF2
N-term 5 W - AF2 AF2
N-term 6 K - AF2 AF2
N-term 7 I - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 M - AF2 AF2
N-term 10 F - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 V - AF2 AF2
N-term 14 R - AF2 AF2
N-term 15 E - AF2 AF2
N-term 16 D - AF2 AF2
N-term 17 S - AF2 AF2
N-term 18 V - AF2 AF2
N-term 19 P - AF2 AF2
N-term 20 T - AF2 AF2
N-term 21 T - AF2 AF2
N-term 22 A - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 F - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 A - AF2 AF2
N-term 27 D - AF2 AF2
N-term 28 M - AF2 AF2
N-term 29 L - AF2 AF2
N-term 30 N - AF2 AF2
N-term 31 V - AF2 AF2
N-term 32 T - AF2 AF2
N-term 33 L - AF2 AF2
N-term 34 Q - AF2 AF2
N-term 35 G - AF2 AF2
N-term 36 P - AF2 AF2
N-term 37 T - AF2 AF2
N-term 38 L - AF2 AF2
N-term 39 N - AF2 AF2
N-term 40 G - AF2 AF2
N-term 41 T - AF2 AF2
N-term 42 F - AF2 AF2
N-term 43 A - AF2 AF2
N-term 44 Q - AF2 AF2
N-term 45 S - AF2 AF2
N-term 46 K - AF2 AF2
N-term 47 C - Structure Structure
N-term 48 P - Structure Structure
N-term 49 Q - Structure Structure
N-term 50 V - Structure Structure
N-term 51 E - Structure Structure
N-term 52 W - Structure Structure
N-term 53 L - Structure Structure
N-term 54 G - Structure Structure
TM1 55 W 1.30x30 Structure Structure
TM1 56 L 1.31x31 Structure Structure
TM1 57 N 1.32x32 Structure Structure
TM1 58 T 1.33x33 Structure Structure
TM1 59 I 1.34x34 Structure Structure
TM1 60 Q 1.35x35 Structure Structure
TM1 61 P 1.36x36 Structure Structure
TM1 62 P 1.37x37 Structure Structure
TM1 63 F 1.38x38 Structure Structure
TM1 64 L 1.39x39 Structure Structure
TM1 65 W 1.40x40 Structure Structure
TM1 66 V 1.41x41 Structure Structure
TM1 67 L 1.42x42 Structure Structure
TM1 68 F 1.43x43 Structure Structure
TM1 69 V 1.44x44 Structure Structure
TM1 70 L 1.45x45 Structure Structure
TM1 71 A 1.46x46 Structure Structure
TM1 72 T 1.47x47 Structure Structure
TM1 73 L 1.48x48 Structure Structure
TM1 74 E 1.49x49 Structure Structure
TM1 75 N 1.50x50 Structure Structure
TM1 76 I 1.51x51 Structure Structure
TM1 77 F 1.52x52 Structure Structure
TM1 78 V 1.53x53 Structure Structure
TM1 79 L 1.54x54 Structure Structure
TM1 80 S 1.55x55 Structure Structure
TM1 81 V 1.56x56 Structure Structure
TM1 82 F 1.57x57 Structure Structure
TM1 83 C 1.58x58 Structure Structure
TM1 84 L 1.59x59 Structure Structure
TM1 85 H 1.60x60 Structure Structure
ICL1 86 K 12.48x48 Structure Structure
ICL1 87 S 12.49x49 Structure Structure
ICL1 88 S 12.50x50 Structure Structure
ICL1 89 C 12.51x51 Structure Structure
TM2 90 T 2.37x37 Structure Structure
TM2 91 V 2.38x38 Structure Structure
TM2 92 A 2.39x39 Structure Structure
TM2 93 E 2.40x40 Structure Structure
TM2 94 I 2.41x41 Structure Structure
TM2 95 Y 2.42x42 Structure Structure
TM2 96 L 2.43x43 Structure Structure
TM2 97 G 2.44x44 Structure Structure
TM2 98 N 2.45x45 Structure Structure
TM2 99 L 2.46x46 Structure Structure
TM2 100 A 2.47x47 Structure Structure
TM2 101 A 2.48x48 Structure Structure
TM2 102 A 2.49x49 Structure Structure
TM2 103 D 2.50x50 Structure Structure
TM2 104 L 2.51x51 Structure Structure
TM2 105 I 2.52x52 Structure Structure
TM2 106 L 2.53x53 Structure Structure
TM2 107 A 2.54x54 Structure Structure
TM2 108 C 2.55x55 Structure Structure
TM2 109 G 2.56x56 Structure Structure
TM2 110 L 2.57x57 Structure Structure
TM2 111 P 2.58x58 Structure Structure
TM2 112 F 2.59x59 Structure Structure
TM2 113 W 2.60x60 Structure Structure
TM2 114 A 2.61x61 Structure Structure
TM2 115 I 2.62x62 Structure Structure
TM2 116 T 2.63x63 Structure Structure
TM2 117 I 2.64x64 Structure Structure
TM2 118 S 2.65x65 Structure Structure
TM2 119 N 2.66x66 Structure Structure
TM2 120 N 2.67x67 Structure Structure
ECL1 121 F - Structure Structure
ECL1 122 D 23.49x49 Structure Structure
ECL1 123 W 23.50x50 Structure Structure
ECL1 124 L 23.51x51 Structure Structure
ECL1 125 F 23.52x52 Structure Structure
TM3 126 G 3.21x21 Structure Structure
TM3 127 E 3.22x22 Structure Structure
TM3 128 T 3.23x23 Structure Structure
TM3 129 L 3.24x24 Structure Structure
TM3 130 C 3.25x25 Structure Structure
TM3 131 R 3.26x26 Structure Structure
TM3 132 V 3.27x27 Structure Structure
TM3 133 V 3.28x28 Structure Structure
TM3 134 N 3.29x29 Structure Structure
TM3 135 A 3.30x30 Structure Structure
TM3 136 I 3.31x31 Structure Structure
TM3 137 I 3.32x32 Structure Structure
TM3 138 S 3.33x33 Structure Structure
TM3 139 M 3.34x34 Structure Structure
TM3 140 N 3.35x35 Structure Structure
TM3 141 L 3.36x36 Structure Structure
TM3 142 Y 3.37x37 Structure Structure
TM3 143 S 3.38x38 Structure Structure
TM3 144 S 3.39x39 Structure Structure
TM3 145 I 3.40x40 Structure Structure
TM3 146 C 3.41x41 Structure Structure
TM3 147 F 3.42x42 Structure Structure
TM3 148 L 3.43x43 Structure Structure
TM3 149 M 3.44x44 Structure Structure
TM3 150 L 3.45x45 Structure Structure
TM3 151 V 3.46x46 Structure Structure
TM3 152 S 3.47x47 Structure Structure
TM3 153 I 3.48x48 Structure Structure
TM3 154 D 3.49x49 Structure Structure
TM3 155 R 3.50x50 Structure Structure
TM3 156 Y 3.51x51 Structure Structure
TM3 157 L 3.52x52 Structure Structure
TM3 158 A 3.53x53 Structure Structure
TM3 159 L 3.54x54 Structure Structure
TM3 160 V 3.55x55 Structure Structure
TM3 161 K 3.56x56 Structure Structure
ICL2 162 T 34.50x50 Structure Structure
ICL2 163 M 34.51x51 Structure Structure
ICL2 164 S 34.52x52 Structure Structure
ICL2 165 M 34.53x53 Structure Structure
ICL2 166 G 34.54x54 Structure Structure
ICL2 167 R 34.55x55 Structure Structure
ICL2 168 M 34.56x56 Structure Structure
ICL2 169 R 34.57x57 Structure Structure
TM4 170 G 4.38x38 Structure Structure
TM4 171 V 4.39x39 Structure Structure
TM4 172 R 4.40x40 Structure Structure
TM4 173 W 4.41x41 Structure Structure
TM4 174 A 4.42x42 Structure Structure
TM4 175 K 4.43x43 Structure Structure
TM4 176 L 4.44x44 Structure Structure
TM4 177 Y 4.45x45 Structure Structure
TM4 178 S 4.46x46 Structure Structure
TM4 179 L 4.47x47 Structure Structure
TM4 180 V 4.48x48 Structure Structure
TM4 181 I 4.49x49 Structure Structure
TM4 182 W 4.50x50 Structure Structure
TM4 183 G 4.51x51 Structure Structure
TM4 184 C 4.52x52 Structure Structure
TM4 185 T 4.53x53 Structure Structure
TM4 186 L 4.54x54 Structure Structure
TM4 187 L 4.55x55 Structure Structure
TM4 188 L 4.56x56 Structure Structure
TM4 189 S 4.57x57 Structure Structure
TM4 190 S 4.58x59 Structure Structure
TM4 191 P 4.59x60 Structure Structure
TM4 192 M 4.60x61 Structure Structure
TM4 193 L 4.61x62 Structure Structure
TM4 194 V 4.62x63 Structure Structure
TM4 195 F 4.63x64 Structure Structure
TM4 196 R 4.64x65 Structure Structure
ECL2 197 T - Structure Structure
ECL2 198 M - Structure Structure
ECL2 199 K - Structure Structure
ECL2 200 E - Structure Structure
ECL2 201 Y - Structure Structure
ECL2 202 S - Structure Structure
ECL2 203 D - Structure Structure
ECL2 204 E - Structure Structure
ECL2 205 G - Structure Structure
ECL2 206 H - Structure Structure
ECL2 207 N - Structure Structure
ECL2 208 V - Structure Structure
ECL2 209 T - Structure Structure
ECL2 210 A - Structure Structure
ECL2 211 C 45.50x50 Structure Structure
ECL2 212 V 45.51x51 Structure Structure
ECL2 213 I 45.52x52 Structure Structure
ECL2 214 S - Structure Structure
ECL2 215 Y - Structure Structure
ECL2 216 P - Structure Structure
TM5 217 S 5.31x32 Structure Structure
TM5 218 L 5.32x33 Structure Structure
TM5 219 I 5.33x34 Structure Structure
TM5 220 W 5.34x35 Structure Structure
TM5 221 E 5.35x36 Structure Structure
TM5 222 V 5.36x37 Structure Structure
TM5 223 F 5.37x38 Structure Structure
TM5 224 T 5.38x39 Structure Structure
TM5 225 N 5.39x40 Structure Structure
TM5 226 M 5.40x41 Structure Structure
TM5 227 L 5.41x42 Structure Structure
TM5 228 L 5.42x43 Structure Structure
TM5 229 N 5.43x44 Structure Structure
TM5 230 V 5.44x45 Structure Structure
TM5 231 V 5.45x46 Structure Structure
TM5 232 G 5.46x461 Structure Structure
TM5 233 F 5.47x47 Structure Structure
TM5 234 L 5.48x48 Structure Structure
TM5 235 L 5.49x49 Structure Structure
TM5 236 P 5.50x50 Structure Structure
TM5 237 L 5.51x51 Structure Structure
TM5 238 S 5.52x52 Structure Structure
TM5 239 V 5.53x53 Structure Structure
TM5 240 I 5.54x54 Structure Structure
TM5 241 T 5.55x55 Structure Structure
TM5 242 F 5.56x56 Structure Structure
TM5 243 C 5.57x57 Structure Structure
TM5 244 T 5.58x58 Structure Structure
TM5 245 M 5.59x59 Structure Structure
TM5 246 Q 5.60x60 Structure Structure
TM5 247 I 5.61x61 Structure Structure
TM5 248 M 5.62x62 Structure Structure
TM5 249 Q 5.63x63 Structure Structure
TM5 250 V 5.64x64 Structure Structure
TM5 251 L 5.65x65 Structure Structure
TM5 252 R 5.66x66 Structure Structure
TM5 253 N 5.67x67 Structure Structure
TM5 254 N 5.68x68 Structure Structure
TM5 255 E 5.69x69 Structure Structure
TM5 256 M 5.70x70 Structure Structure
TM5 257 Q 5.71x71 Structure Structure
TM5 258 K 5.72x72 Structure Structure
ICL3 259 F - Structure Structure
ICL3 260 K - Structure Structure
ICL3 261 E - Structure Structure
TM6 262 I 6.27x27 Structure Structure
TM6 263 Q 6.28x28 Structure Structure
TM6 264 T 6.29x29 Structure Structure
TM6 265 E 6.30x30 Structure Structure
TM6 266 R 6.31x31 Structure Structure
TM6 267 R 6.32x32 Structure Structure
TM6 268 A 6.33x33 Structure Structure
TM6 269 T 6.34x34 Structure Structure
TM6 270 V 6.35x35 Structure Structure
TM6 271 L 6.36x36 Structure Structure
TM6 272 V 6.37x37 Structure Structure
TM6 273 L 6.38x38 Structure Structure
TM6 274 V 6.39x39 Structure Structure
TM6 275 V 6.40x40 Structure Structure
TM6 276 L 6.41x41 Structure Structure
TM6 277 L 6.42x42 Structure Structure
TM6 278 L 6.43x43 Structure Structure
TM6 279 F 6.44x44 Structure Structure
TM6 280 I 6.45x45 Structure Structure
TM6 281 I 6.46x46 Structure Structure
TM6 282 C 6.47x47 Structure Structure
TM6 283 W 6.48x48 Structure Structure
TM6 284 L 6.49x49 Structure Structure
TM6 285 P 6.50x50 Structure Structure
TM6 286 F 6.51x51 Structure Structure
TM6 287 Q 6.52x52 Structure Structure
TM6 288 I 6.53x53 Structure Structure
TM6 289 S 6.54x54 Structure Structure
TM6 290 T 6.55x55 Structure Structure
TM6 291 F 6.56x56 Structure Structure
TM6 292 L 6.57x57 Structure Structure
TM6 293 D 6.58x58 Structure Structure
TM6 294 T 6.59x59 Structure Structure
TM6 295 L 6.60x60 Structure Structure
TM6 296 H 6.61x61 Structure Structure
TM6 297 R 6.62x62 Structure Structure
TM6 298 L 6.63x63 Structure Structure
TM6 299 G 6.64x64 Structure Structure
ECL3 300 I - Structure Structure
ECL3 301 L - Structure Structure
ECL3 302 S - Structure Structure
TM7 303 S 7.24x23 Structure Structure
TM7 304 C 7.25x24 Structure Structure
TM7 305 Q 7.26x25 Structure Structure
TM7 306 D 7.27x26 Structure Structure
TM7 307 E 7.28x27 Structure Structure
TM7 308 R 7.29x28 Structure Structure
TM7 309 I 7.30x29 Structure Structure
TM7 310 I 7.31x30 Structure Structure
TM7 311 D 7.32x31 Structure Structure
TM7 312 V 7.33x32 Structure Structure
TM7 313 I 7.34x33 Structure Structure
TM7 314 T 7.35x34 Structure Structure
TM7 315 Q 7.36x35 Structure Structure
TM7 316 I 7.37x36 Structure Structure
TM7 317 A 7.38x37 Structure Structure
TM7 318 S 7.39x38 Structure Structure
TM7 319 F 7.40x39 Structure Structure
TM7 320 M 7.41x40 Structure Structure
TM7 321 A 7.42x41 Structure Structure
TM7 322 Y 7.43x42 Structure Structure
TM7 323 S 7.44x43 Structure Structure
TM7 324 N 7.45x45 Structure Structure
TM7 325 S 7.46x46 Structure Structure
TM7 326 C 7.47x47 Structure Structure
TM7 327 L 7.48x48 Structure Structure
TM7 328 N 7.49x49 Structure Structure
TM7 329 P 7.50x50 Structure Structure
TM7 330 L 7.51x51 Structure Structure
TM7 331 V 7.52x52 Structure Structure
TM7 332 Y 7.53x53 Structure Structure
TM7 333 V 7.54x54 Structure Structure
TM7 334 I 7.55x55 Structure Structure
TM7 335 V 7.56x56 Structure Structure
H8 336 G 8.47x47 Structure Structure
H8 337 K 8.48x48 Structure Structure
H8 338 R 8.49x49 Structure Structure
H8 339 F 8.50x50 Structure Structure
H8 340 R 8.51x51 Structure Structure
H8 341 K 8.52x52 Structure Structure
H8 342 K 8.53x53 Structure Structure
H8 343 S 8.54x54 Structure Structure
H8 344 W 8.55x55 Structure Structure
H8 345 E 8.56x56 Structure Structure
H8 346 V 8.57x57 Structure Structure
C-term 347 Y - Structure Structure
C-term 348 Q - Structure Structure
C-term 349 G - Structure Structure
C-term 350 V - Structure Structure
C-term 351 C - Structure Structure
C-term 352 Q - AF2 AF2
C-term 353 K - AF2 AF2
C-term 354 G - AF2 AF2
C-term 355 G - AF2 AF2
C-term 356 C - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 F 259 - G.S6 S 326 G.S6.03
Van-der-waals ICL3 F 259 - G.S6 S 326 G.S6.03
Hydrophobic ICL2 M 168 34x56 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 M 168 34x56 G.hns1 R 37 G.hns1.02
Hydrophobic ICL3 F 259 - G.h4s6 I 323 G.h4s6.20
Hydrophobic ICL2 R 167 34x55 G.H5 I 348 G.H5.15
Van-der-waals ICL2 R 167 34x55 G.H5 I 348 G.H5.15
Hydrophobic TM3 L 159 3x54 G.H5 N 352 G.H5.19
Ionic ICL2 R 169 34x57 G.H5 E 355 G.H5.22
Polar ICL2 R 169 34x57 G.H5 E 355 G.H5.22
Polar TM7 Y 332 7x53 G.H5 N 357 G.H5.24
Hydrophobic TM6 A 268 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM2 A 92 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 A 92 2x39 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 T 162 34x50 G.H5 K 345 G.H5.12
Hydrophobic TM5 L 251 5x65 G.H5 L 353 G.H5.20
Van-der-waals ICL2 T 162 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM3 L 159 3x54 G.H5 L 353 G.H5.20
Polar TM6 A 268 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 268 6x33 G.H5 L 358 G.H5.25
Polar TM6 E 265 6x30 G.H5 Q 350 G.H5.17
Van-der-waals TM6 E 265 6x30 G.H5 Q 350 G.H5.17
Polar ICL2 R 169 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL3 K 260 - G.h4s6 I 323 G.h4s6.20
Hydrophobic ICL2 M 163 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 M 163 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM5 Q 257 5x71 G.H5 D 346 G.H5.13
Van-der-waals TM5 Q 257 5x71 G.H5 D 346 G.H5.13
Polar ICL2 T 162 34x50 G.H5 N 352 G.H5.19
Hydrophobic H8 G 336 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 G 336 8x47 G.H5 N 357 G.H5.24
Polar TM3 A 158 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM5 Q 257 5x71 G.H5 A 342 G.H5.09
Hydrophobic TM5 Q 257 5x71 G.S6 Y 325 G.S6.02
Van-der-waals TM5 Q 257 5x71 G.S6 Y 325 G.S6.02
Hydrophobic ICL3 F 259 - G.H5 F 339 G.H5.06
Hydrophobic ICL2 M 163 34x51 G.H5 F 341 G.H5.08
Hydrophobic TM3 R 155 3x50 G.H5 L 358 G.H5.25
Polar H8 F 339 8x50 G.H5 N 357 G.H5.24
Hydrophobic H8 F 339 8x50 G.H5 N 357 G.H5.24
Polar H8 K 337 8x48 G.H5 V 359 G.H5.26
Hydrophobic TM6 V 272 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM3 A 158 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 L 159 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 R 167 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 167 34x55 G.hns1 R 37 G.hns1.02
Polar TM2 V 91 2x38 G.H5 E 355 G.H5.22
Polar TM3 D 154 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 154 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 154 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM6 R 267 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 R 267 6x32 G.H5 V 359 G.H5.26
Hydrophobic ICL2 M 168 34x56 G.hns1 R 38 G.hns1.03
Polar TM3 R 155 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 155 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 155 3x50 G.H5 Y 356 G.H5.23
Polar TM2 T 90 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM2 T 90 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 T 90 2x37 G.H5 E 355 G.H5.22
Ionic ICL3 K 260 - G.H5 D 346 G.H5.13
Polar ICL3 K 260 - G.H5 D 346 G.H5.13
Van-der-waals ICL3 K 260 - G.H5 D 346 G.H5.13
Hydrophobic ICL2 M 163 34x51 G.H5 K 345 G.H5.12
Van-der-waals ICL2 M 163 34x51 G.H5 K 345 G.H5.12
Polar TM6 T 264 6x29 G.H5 Q 350 G.H5.17
Hydrophobic TM3 V 151 3x46 G.H5 Y 356 G.H5.23
Hydrophobic TM4 G 170 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 T 264 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM6 L 271 6x36 G.H5 L 358 G.H5.25
Hydrophobic ICL3 F 259 - G.S6 Y 325 G.S6.02
Van-der-waals ICL3 F 259 - G.S6 Y 325 G.S6.02
Polar TM7 V 333 7x54 G.H5 N 357 G.H5.24
Hydrophobic TM7 V 333 7x54 G.H5 N 357 G.H5.24
Polar TM2 A 92 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM2 A 92 2x39 G.H5 E 355 G.H5.22
Hydrophobic ICL3 K 260 - G.H5 Q 350 G.H5.17
Hydrophobic TM3 L 159 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 L 159 3x54 G.H5 L 358 G.H5.25
Hydrophobic H8 R 338 8x49 G.H5 K 354 G.H5.21
Hydrophobic TM5 N 254 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 N 254 5x68 G.H5 L 349 G.H5.16