FFA4 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

June 21, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

GW9508 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

oleic acid, myristic acid, α-linolenic acid, linoleic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
R12G.H4Q17N19Y23G.H5GproteinC3x53A-L5x76R5x69R3x50I3x54GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.H4G.H5GPCR segments:TM3ICL3TM5

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null3x503x533x545x645x655x685x695x715x725x766x266x346x38G.H5.25G.H5.24G.H5.23G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.10G.S6.04G.S6.03G.S6.02G.S6.01G.h4s6.20G.h4s6.09G.H4.17G.H4.16G.H4.13G.H4.12G.S3.01G.hns1.03Res. Pos.FFA4 (8H4K)- (8H4K)--------------RCIITSRRLLRLLRCIITSRRLLRLLAYLNLLDQDYIRPHGKVDKINVCR

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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