Structure information

FFA4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8H4K

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-023-00835-X

PUBLICATION DATE

June 21, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
GW9508 F27 N-term aromatic (edge-to-face)
GW9508 M118 3.32x32 TM3 hydrophobic
GW9508 I126 3.40x40 TM3 hydrophobic
GW9508 L173 4.60x61 TM4 hydrophobic
GW9508 F177 ECL2 hydrophobic
GW9508 W198 ECL2 polar (hydrogen bond)
GW9508 W198 ECL2 Van der Waals
GW9508 E204 5.35x36 TM5 polar (charge-assisted hydrogen bond)
GW9508 D208 5.39x40 TM5 polar (charge-assisted hydrogen bond)
GW9508 F211 5.42x43 TM5 Van der Waals
GW9508 F211 5.42x43 TM5 aromatic (edge-to-face)
GW9508 W277 6.48x48 TM6 Van der Waals
GW9508 W277 6.48x48 TM6 hydrophobic
GW9508 I284 6.55x55 TM6 hydrophobic
GW9508 I284 6.55x55 TM6 Van der Waals
GW9508 I287 6.58x58 TM6 hydrophobic
GW9508 I287 6.58x58 TM6 Van der Waals
GW9508 L288 6.59x59 TM6 Van der Waals
GW9508 F303 7.35x34 TM7 Van der Waals
GW9508 F303 7.35x34 TM7 hydrophobic

Ligands

GW9508

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Residue Diagrams

V N G L L S V A F I L V L V T T E V A A 1 L N L F C A D L L F I S A I P L V L A V 2 A A L T L I T V S G S L T M V Y F L L H 3 R A V L L A L I W G Y S A V A A L P L 4 Y S I V I V L G P V L F N L T V F S V D W 5 L F L L M V S F I F M W S P I I I T I L L 6 I P N L A S N A F T F A V V W F F L S 7
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ICL1 R R R G A T ICL1ECL1 E A W L L ECL1ICL2 L Q R G V R G P ICL2ECL2 R V V P Q R L P G A D Q E I S I C T L I W P ECL2ICL3 A Y ICL3ECL3 D L V I ECL3N-term M S P E C A R A A G D A P L R S L E Q A N R T R F P F F S D V K G D N-termC-term P E K G A I L T D T S V K R N D L S I I S G C-term H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R A C L V L N L F C A D L L F I S A I P L V L A V R W T G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H G R R A R A V L L A L I W G Y S A V A A L P L C V F F T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q W P S L F F W V V A F T F A N S A L N P I L Y N M T L C R K I F F N E W K C C F W
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Residue Table


GPCRdb(A)
GPCRdb(A)
FFA4 receptor
TM3
3x32 3.32x32 M118
3x40 3.40x40 I126
TM4
4x61 4.60x61 L173
TM5
5x36 5.35x36 E204
5x40 5.39x40 D208
5x43 5.42x43 F211
TM6
6x48 6.48x48 W277
6x55 6.55x55 I284
6x58 6.58x58 I287
6x59 6.59x59 L288
TM7
7x34 7.35x34 F303