NTS1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

June 3, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

JMV449 - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

large neuromedin N (Mouse), neurotensin (Human), neuromedin N (Human), large neuromedin N (Human), large neuromedin N (Rat), large neurotensin (Human), neuromedin N (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar ICL2 T 190 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 T 190 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 T 190 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL1 L 106 - G.h2s4 E 216 G.h2s4.02
Hydrophobic TM3 A 181 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 181 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 A 309 6x29 G.H5 L 348 G.H5.20
Hydrophobic H8 S 380 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 L 310 6x30 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 182 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 A 309 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 309 6x29 G.H5 F 354 G.H5.26
Polar TM2 Q 110 2x36 G.H5 N 346 G.H5.18
Hydrophobic TM3 I 182 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 182 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM7 Y 376 7x53 G.H5 G 352 G.H5.24
Hydrophobic TM6 L 317 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 182 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 310 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM2 Q 110 2x36 G.H5 D 350 G.H5.22
Van-der-waals TM2 Q 110 2x36 G.H5 D 350 G.H5.22
Hydrophobic TM6 V 316 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM2 L 109 2x35 G.H5 D 350 G.H5.22
Hydrophobic TM2 V 113 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 V 113 2x39 G.H5 D 350 G.H5.22
Polar H8 S 380 8x47 G.H5 F 354 G.H5.26
Hydrophobic H8 S 380 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 S 380 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 178 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 178 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 306 6x26 G.H5 I 344 G.H5.16
Van-der-waals TM6 R 306 6x26 G.H5 I 344 G.H5.16
Polar TM3 R 178 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 178 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 178 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM2 V 113 2x39 G.H5 C 351 G.H5.23
Polar TM6 R 306 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 306 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 306 6x26 G.H5 D 341 G.H5.13
Polar H8 A 381 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 A 381 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 N 382 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 382 8x49 G.H5 K 349 G.H5.21
Hydrophobic ICL2 F 186 34x51 G.hns1 R 32 G.hns1.03
Polar TM6 R 306 6x26 G.H5 D 337 G.H5.09
Hydrophobic TM5 L 275 5x65 G.H5 L 348 G.H5.20
Polar H8 S 380 8x47 G.H5 L 353 G.H5.25
Hydrophobic H8 S 380 8x47 G.H5 L 353 G.H5.25
Ionic H8 H 385 8x52 G.h4s6 D 315 G.h4s6.09
Polar H8 H 385 8x52 G.h4s6 D 315 G.h4s6.09
Hydrophobic H8 H 385 8x52 G.h4s6 D 315 G.h4s6.09
Van-der-waals H8 H 385 8x52 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 L 275 5x65 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 306 6x26 G.H5 T 340 G.H5.12