PDB
20ZK
Resolution
2.7 Å
Released
June 3, 2026
Receptor
NTS1
Class
A
Species
Homo sapiens
Ligand
Function
JMV449
Agonist
Reference
10.1038/S41586-026-10228-W

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Ligand Amino Acid Generic Number Segment Interaction Type
JMV449 L66 N-term Van der Waals
JMV449 D67 N-term Van der Waals
JMV449 V68 N-term Van der Waals
JMV449 N138 2.64x63 TM2 Van der Waals
JMV449 F139 2.65x64 TM2 hydrophobic
JMV449 H143 ECL1 Van der Waals
JMV449 Y157 3.29x29 TM3 hydrophobic
JMV449 M219 4.64x65 TM4 hydrophobic
JMV449 V235 ECL2 hydrophobic
JMV449 P238 45.52x52 ECL2 Van der Waals
JMV449 R334 6.54x54 TM6 polar (charge-charge)
JMV449 F338 6.58x58 TM6 hydrophobic
JMV449 I341 6.61x61 TM6 polar (hydrogen bond with backbone)
JMV449 D343 ECL3 polar (hydrogen bond)
JMV449 D343 ECL3 polar (charge-charge)
JMV449 W346 ECL3 hydrophobic
JMV449 Y351 7.28x27 TM7 hydrophobic
JMV449 Y354 7.31x30 TM7 hydrophobic
JMV449 Y354 7.31x30 TM7 polar (hydrogen bond)
JMV449 Y358 7.35x34 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
Helix box plot — Download: PNG | SVG T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7

GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x63 2.64x63 N126
2x64 2.65x64 F127
TM3
3x29 3.29x29 Y145
TM4
4x65 4.64x65 M207
ECL2
45x52 45.52x52 P226
TM6
6x54 6.54x54 R322
6x58 6.58x58 F326
6x61 6.61x61 I329
TM7
7x27 7.28x27 Y339
7x30 7.31x30 Y342
7x34 7.35x34 Y346