Refined structure (8HQE) of Gi1 - GPR132

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-07-12

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 214 from structure (60.5%), 140 from model (39.5%)
Residue sidechains - 203 from structure (57.3%), 151 from model (42.7%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure AF2
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure AF2
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure AF2
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure AF2
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 AF2 AF2
G.HG 280 K G.HG.12 AF2 AF2
G.HG 281 S G.HG.13 AF2 AF2
G.HG 282 P G.HG.14 AF2 AF2
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure AF2
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure AF2
G.h4s6 314 K G.h4s6.08 Structure AF2
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure AF2
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 302 from structure (88.6%), 39 from model (11.4%)
Residue sidechains - 302 from structure (88.6%), 39 from model (11.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 C - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 M - AF2 AF2
N-term 5 L - AF2 AF2
N-term 6 L - AF2 AF2
N-term 7 K - AF2 AF2
N-term 8 N - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 Y - AF2 AF2
N-term 11 N - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 N - AF2 AF2
N-term 14 A - AF2 AF2
N-term 15 T - AF2 AF2
N-term 16 P - AF2 AF2
N-term 17 V - AF2 AF2
N-term 18 T - AF2 AF2
N-term 19 T - AF2 AF2
N-term 20 T - AF2 AF2
N-term 21 A - AF2 AF2
N-term 22 P - AF2 AF2
N-term 23 W - AF2 AF2
N-term 24 A - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 L - AF2 AF2
N-term 27 G - AF2 AF2
N-term 28 L - AF2 AF2
N-term 29 S - AF2 AF2
N-term 30 A - AF2 AF2
N-term 31 K - AF2 AF2
N-term 32 T - AF2 AF2
N-term 33 C - AF2 AF2
N-term 34 N - AF2 AF2
N-term 35 N - AF2 AF2
N-term 36 V - AF2 AF2
TM1 37 S 1.27x27 Structure Structure
TM1 38 F 1.28x28 Structure Structure
TM1 39 E 1.29x29 Structure Structure
TM1 40 E 1.30x30 Structure Structure
TM1 41 S 1.31x31 Structure Structure
TM1 42 R 1.32x32 Structure Structure
TM1 43 I 1.33x33 Structure Structure
TM1 44 V 1.34x34 Structure Structure
TM1 45 L 1.35x35 Structure Structure
TM1 46 V 1.36x36 Structure Structure
TM1 47 V 1.37x37 Structure Structure
TM1 48 V 1.38x38 Structure Structure
TM1 49 Y 1.39x39 Structure Structure
TM1 50 S 1.40x40 Structure Structure
TM1 51 A 1.41x41 Structure Structure
TM1 52 V 1.42x42 Structure Structure
TM1 53 C 1.43x43 Structure Structure
TM1 54 T 1.44x44 Structure Structure
TM1 55 L 1.45x45 Structure Structure
TM1 56 G 1.46x46 Structure Structure
TM1 57 V 1.47x47 Structure Structure
TM1 58 P 1.48x48 Structure Structure
TM1 59 A 1.49x49 Structure Structure
TM1 60 N 1.50x50 Structure Structure
TM1 61 C 1.51x51 Structure Structure
TM1 62 L 1.52x52 Structure Structure
TM1 63 T 1.53x53 Structure Structure
TM1 64 A 1.54x54 Structure Structure
TM1 65 W 1.55x55 Structure Structure
TM1 66 L 1.56x56 Structure Structure
TM1 67 A 1.57x57 Structure Structure
TM1 68 L 1.58x58 Structure Structure
TM1 69 L 1.59x59 Structure Structure
TM1 70 Q 1.60x60 Structure Structure
TM1 71 V 1.61x61 Structure Structure
ICL1 72 L - Structure Structure
ICL1 73 Q - Structure Structure
ICL1 74 G - Structure Structure
TM2 75 N 2.37x37 Structure Structure
TM2 76 V 2.38x38 Structure Structure
TM2 77 L 2.39x39 Structure Structure
TM2 78 A 2.40x40 Structure Structure
TM2 79 V 2.41x41 Structure Structure
TM2 80 Y 2.42x42 Structure Structure
TM2 81 L 2.43x43 Structure Structure
TM2 82 L 2.44x44 Structure Structure
TM2 83 C 2.45x45 Structure Structure
TM2 84 L 2.46x46 Structure Structure
TM2 85 A 2.47x47 Structure Structure
TM2 86 L 2.48x48 Structure Structure
TM2 87 C 2.49x49 Structure Structure
TM2 88 E 2.50x50 Structure Structure
TM2 89 L 2.51x51 Structure Structure
TM2 90 L 2.52x52 Structure Structure
TM2 91 Y 2.53x53 Structure Structure
TM2 92 T 2.54x54 Structure Structure
TM2 93 G 2.55x55 Structure Structure
TM2 94 T 2.56x56 Structure Structure
TM2 95 L 2.57x57 Structure Structure
TM2 96 P 2.58x58 Structure Structure
TM2 97 L 2.59x59 Structure Structure
TM2 98 W 2.60x60 Structure Structure
TM2 99 V 2.61x61 Structure Structure
TM2 100 I 2.62x62 Structure Structure
TM2 101 Y 2.63x63 Structure Structure
TM2 102 I 2.64x64 Structure Structure
ECL1 103 R - Structure Structure
ECL1 104 N - Structure Structure
ECL1 105 Q - Structure Structure
ECL1 106 H - Structure Structure
ECL1 107 R 23.49x49 Structure Structure
ECL1 108 W 23.50x50 Structure Structure
ECL1 109 T 23.51x51 Structure Structure
ECL1 110 L 23.52x52 Structure Structure
TM3 111 G 3.21x21 Structure Structure
TM3 112 L 3.22x22 Structure Structure
TM3 113 L 3.23x23 Structure Structure
TM3 114 A 3.24x24 Structure Structure
TM3 115 C 3.25x25 Structure Structure
TM3 116 K 3.26x26 Structure Structure
TM3 117 V 3.27x27 Structure Structure
TM3 118 T 3.28x28 Structure Structure
TM3 119 A 3.29x29 Structure Structure
TM3 120 Y 3.30x30 Structure Structure
TM3 121 I 3.31x31 Structure Structure
TM3 122 F 3.32x32 Structure Structure
TM3 123 F 3.33x33 Structure Structure
TM3 124 C 3.34x34 Structure Structure
TM3 125 N 3.35x35 Structure Structure
TM3 126 I 3.36x36 Structure Structure
TM3 127 Y 3.37x37 Structure Structure
TM3 128 V 3.38x38 Structure Structure
TM3 129 S 3.39x39 Structure Structure
TM3 130 I 3.40x40 Structure Structure
TM3 131 L 3.41x41 Structure Structure
TM3 132 F 3.42x42 Structure Structure
TM3 133 L 3.43x43 Structure Structure
TM3 134 C 3.44x44 Structure Structure
TM3 135 C 3.45x45 Structure Structure
TM3 136 I 3.46x46 Structure Structure
TM3 137 S 3.47x47 Structure Structure
TM3 138 C 3.48x48 Structure Structure
TM3 139 D 3.49x49 Structure Structure
TM3 140 R 3.50x50 Structure Structure
TM3 141 F 3.51x51 Structure Structure
TM3 142 V 3.52x52 Structure Structure
TM3 143 A 3.53x53 Structure Structure
TM3 144 V 3.54x54 Structure Structure
TM3 145 V 3.55x55 Structure Structure
TM3 146 Y 3.56x56 Structure Structure
ICL2 147 A 34.50x50 Structure Structure
ICL2 148 L 34.51x51 Structure Structure
ICL2 149 E 34.52x52 Structure Structure
ICL2 150 S 34.53x53 Structure Structure
ICL2 151 R 34.54x54 Structure Structure
ICL2 152 G 34.55x55 Structure Structure
ICL2 153 R 34.56x56 Structure Structure
ICL2 154 R 34.57x57 Structure Structure
TM4 155 R 4.38x38 Structure Structure
TM4 156 R 4.39x39 Structure Structure
TM4 157 R 4.40x40 Structure Structure
TM4 158 T 4.41x41 Structure Structure
TM4 159 A 4.42x42 Structure Structure
TM4 160 I 4.43x43 Structure Structure
TM4 161 L 4.44x44 Structure Structure
TM4 162 I 4.45x45 Structure Structure
TM4 163 S 4.46x46 Structure Structure
TM4 164 A 4.47x47 Structure Structure
TM4 165 C 4.48x48 Structure Structure
TM4 166 I 4.49x49 Structure Structure
TM4 167 F 4.50x50 Structure Structure
TM4 168 I 4.51x51 Structure Structure
TM4 169 L 4.52x52 Structure Structure
TM4 170 V 4.53x53 Structure Structure
TM4 171 G 4.54x54 Structure Structure
TM4 172 I 4.55x55 Structure Structure
TM4 173 V 4.56x56 Structure Structure
TM4 174 H 4.57x57 Structure Structure
TM4 175 Y 4.58x59 Structure Structure
TM4 176 P 4.59x60 Structure Structure
TM4 177 V 4.60x61 Structure Structure
TM4 178 F 4.61x62 Structure Structure
TM4 179 Q 4.62x63 Structure Structure
TM4 180 T 4.63x64 Structure Structure
ECL2 181 E - Structure Structure
ECL2 182 D - Structure Structure
ECL2 183 K - Structure Structure
ECL2 184 E - Structure Structure
ECL2 185 T - Structure Structure
ECL2 186 C 45.50x50 Structure Structure
ECL2 187 F 45.51x51 Structure Structure
ECL2 188 D 45.52x52 Structure Structure
ECL2 189 M - Structure Structure
ECL2 190 L - Structure Structure
ECL2 191 Q - Structure Structure
ECL2 192 M - Structure Structure
TM5 193 D 5.32x33 Structure Structure
TM5 194 S 5.33x34 Structure Structure
TM5 195 R 5.34x35 Structure Structure
TM5 196 I 5.35x36 Structure Structure
TM5 197 A 5.36x37 Structure Structure
TM5 198 G 5.37x38 Structure Structure
TM5 199 Y 5.38x39 Structure Structure
TM5 200 Y 5.39x40 Structure Structure
TM5 201 Y 5.40x41 Structure Structure
TM5 202 A 5.41x42 Structure Structure
TM5 203 R 5.42x43 Structure Structure
TM5 204 F 5.43x44 Structure Structure
TM5 205 T 5.44x45 Structure Structure
TM5 206 V 5.45x46 Structure Structure
TM5 207 G 5.46x461 Structure Structure
TM5 208 F 5.47x47 Structure Structure
TM5 209 A 5.48x48 Structure Structure
TM5 210 I 5.49x49 Structure Structure
TM5 211 P 5.50x50 Structure Structure
TM5 212 L 5.51x51 Structure Structure
TM5 213 S 5.52x52 Structure Structure
TM5 214 I 5.53x53 Structure Structure
TM5 215 I 5.54x54 Structure Structure
TM5 216 A 5.55x55 Structure Structure
TM5 217 F 5.56x56 Structure Structure
TM5 218 T 5.57x57 Structure Structure
TM5 219 N 5.58x58 Structure Structure
TM5 220 H 5.59x59 Structure Structure
TM5 221 R 5.60x60 Structure Structure
TM5 222 I 5.61x61 Structure Structure
TM5 223 F 5.62x62 Structure Structure
TM5 224 R 5.63x63 Structure Structure
TM5 225 S 5.64x64 Structure Structure
TM5 226 I 5.65x65 Structure Structure
TM5 227 K 5.66x66 Structure Structure
TM5 228 Q 5.67x67 Structure Structure
TM5 229 S 5.68x68 Structure Structure
ICL3 230 M - Structure Structure
ICL3 231 G - Structure Structure
ICL3 232 L - Structure Structure
TM6 233 S 6.26x26 Structure Structure
TM6 234 A 6.27x27 Structure Structure
TM6 235 A 6.28x28 Structure Structure
TM6 236 Q 6.29x29 Structure Structure
TM6 237 K 6.30x30 Structure Structure
TM6 238 A 6.31x31 Structure Structure
TM6 239 K 6.32x32 Structure Structure
TM6 240 V 6.33x33 Structure Structure
TM6 241 K 6.34x34 Structure Structure
TM6 242 H 6.35x35 Structure Structure
TM6 243 S 6.36x36 Structure Structure
TM6 244 A 6.37x37 Structure Structure
TM6 245 I 6.38x38 Structure Structure
TM6 246 A 6.39x39 Structure Structure
TM6 247 V 6.40x40 Structure Structure
TM6 248 V 6.41x41 Structure Structure
TM6 249 V 6.42x42 Structure Structure
TM6 250 I 6.43x43 Structure Structure
TM6 251 F 6.44x44 Structure Structure
TM6 252 L 6.45x45 Structure Structure
TM6 253 V 6.46x46 Structure Structure
TM6 254 C 6.47x47 Structure Structure
TM6 255 F 6.48x48 Structure Structure
TM6 256 A 6.49x49 Structure Structure
TM6 257 P 6.50x50 Structure Structure
TM6 258 Y 6.51x51 Structure Structure
TM6 259 H 6.52x52 Structure Structure
TM6 260 L 6.53x53 Structure Structure
TM6 261 V 6.54x54 Structure Structure
TM6 262 L 6.55x55 Structure Structure
TM6 263 L 6.56x56 Structure Structure
TM6 264 V 6.57x57 Structure Structure
TM6 265 K 6.58x58 Structure Structure
TM6 266 A 6.59x59 Structure Structure
TM6 267 A 6.60x60 Structure Structure
TM6 268 A 6.61x61 Structure Structure
TM6 269 F 6.62x62 Structure Structure
TM6 270 S 6.63x63 Structure Structure
TM6 271 Y 6.64x64 Structure Structure
TM6 272 Y 6.65x65 Structure Structure
TM6 273 R 6.66x66 Structure Structure
ECL3 274 G - Structure Structure
ECL3 275 D - AF2 AF2
ECL3 276 R - AF2 AF2
ECL3 277 N - AF2 AF2
TM7 278 A 7.23x22 Structure Structure
TM7 279 M 7.24x23 Structure Structure
TM7 280 C 7.25x24 Structure Structure
TM7 281 G 7.26x25 Structure Structure
TM7 282 L 7.27x26 Structure Structure
TM7 283 E 7.28x27 Structure Structure
TM7 284 E 7.29x28 Structure Structure
TM7 285 R 7.30x29 Structure Structure
TM7 286 L 7.31x30 Structure Structure
TM7 287 Y 7.32x31 Structure Structure
TM7 288 T 7.33x32 Structure Structure
TM7 289 A 7.34x33 Structure Structure
TM7 290 S 7.35x34 Structure Structure
TM7 291 V 7.36x35 Structure Structure
TM7 292 V 7.37x36 Structure Structure
TM7 293 F 7.38x37 Structure Structure
TM7 294 L 7.39x38 Structure Structure
TM7 295 C 7.40x39 Structure Structure
TM7 296 L 7.41x40 Structure Structure
TM7 297 S 7.42x41 Structure Structure
TM7 298 T 7.43x42 Structure Structure
TM7 299 V 7.44x43 Structure Structure
TM7 300 N 7.45x45 Structure Structure
TM7 301 G 7.46x46 Structure Structure
TM7 302 V 7.47x47 Structure Structure
TM7 303 A 7.48x48 Structure Structure
TM7 304 D 7.49x49 Structure Structure
TM7 305 P 7.50x50 Structure Structure
TM7 306 I 7.51x51 Structure Structure
TM7 307 I 7.52x52 Structure Structure
TM7 308 Y 7.53x53 Structure Structure
TM7 309 V 7.54x54 Structure Structure
TM7 310 L 7.55x55 Structure Structure
TM7 311 A 7.56x56 Structure Structure
H8 312 T 8.47x47 Structure Structure
H8 313 D 8.48x48 Structure Structure
H8 314 H 8.49x49 Structure Structure
H8 315 S 8.50x50 Structure Structure
H8 316 R 8.51x51 Structure Structure
H8 317 Q 8.52x52 Structure Structure
H8 318 E 8.53x53 Structure Structure
H8 319 V 8.54x54 Structure Structure
H8 320 S 8.55x55 Structure Structure
H8 321 R 8.56x56 Structure Structure
H8 322 I 8.57x57 Structure Structure
H8 323 H 8.58x58 Structure Structure
H8 324 K 8.59x59 Structure Structure
H8 325 G 8.60x60 Structure Structure
H8 326 W 8.61x61 Structure Structure
H8 327 K 8.62x62 Structure Structure
H8 328 E 8.63x63 Structure Structure
H8 329 W 8.64x64 Structure Structure
H8 330 S 8.65x65 Structure Structure
H8 331 M 8.66x66 Structure Structure
C-term 332 K - Structure Structure
C-term 333 T - Structure Structure
C-term 334 D - Structure Structure
C-term 335 V - Structure Structure
C-term 336 T - Structure Structure
C-term 337 R - Structure Structure
C-term 338 L - Structure Structure
C-term 339 T - Structure Structure
C-term 340 H - Structure Structure
C-term 341 S - Structure Structure



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 Q 236 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 236 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 S 243 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 243 6x36 G.H5 L 353 G.H5.25
Polar TM3 A 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 347 G.H5.19
Polar TM6 K 239 6x32 G.H5 L 353 G.H5.25
Polar ICL3 G 231 - G.H5 K 345 G.H5.17
Hydrophobic TM6 V 240 6x33 G.H5 F 354 G.H5.26
Polar TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 232 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 147 34x50 G.H5 I 344 G.H5.16
Polar TM2 N 75 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 75 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 L 77 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 L 77 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 L 77 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 L 77 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 K 239 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 239 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 240 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 240 6x33 G.H5 L 353 G.H5.25