NPFF1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

July 23, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

neuropeptide FF - Agonist

PHYSIOLOGICAL LIGANDS

QRFP43 (43RFa) (Human), neuropeptide AF (Rat), neuropeptide AF (Human), neuropeptide SF (Mouse), RFRP-3 (Human), neuropeptide SF (Human), PrRP-31 (Human), neuropeptide AF (Mouse), neuropeptide FF (Human), RFRP-1 (Human), neuropeptide SF (Rat)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM5 L 243 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 243 5x65 G.H5 L 348 G.H5.20
Polar TM3 C 144 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 144 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 144 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 141 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 243 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 268 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 268 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 268 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 F 149 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 F 149 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 I 145 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 145 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL4 N 333 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 N 333 - G.H5 G 352 G.H5.24
Hydrophobic TM6 L 272 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 145 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 268 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 V 268 6x33 G.H5 L 348 G.H5.20
Polar ICL4 N 333 - G.H5 F 354 G.H5.26
Hydrophobic ICL4 N 333 - G.H5 F 354 G.H5.26
Van-der-waals ICL4 N 333 - G.H5 F 354 G.H5.26
Hydrophobic TM6 R 267 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 267 6x32 G.H5 F 354 G.H5.26
Polar ICL2 F 149 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 149 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 F 149 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL4 F 332 - G.H5 F 354 G.H5.26
Hydrophobic TM2 T 78 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 148 - G.H5 N 347 G.H5.19
Hydrophobic TM3 I 145 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 145 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL4 N 335 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 N 335 - G.H5 G 352 G.H5.24
Hydrophobic ICL3 R 264 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 R 264 - G.H5 F 354 G.H5.26