PDB
9M2F
Resolution
2.9 Å
Released
July 23, 2025
Receptor
NPFF1
Class
A
Species
Homo sapiens
Ligand
neuropeptide FF
Function
Agonist
Reference
10.1016/J.CELREP.2025.116160

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Ligand Amino Acid Generic Number Segment Interaction Type
neuropeptide FF Q37 N-term polar (hydrogen bond)
neuropeptide FF Q37 N-term Van der Waals
neuropeptide FF N104 2.65x64 TM2 Van der Waals
neuropeptide FF T107 ECL1 polar (hydrogen bond with backbone)
neuropeptide FF T107 ECL1 Van der Waals
neuropeptide FF G120 3.29x29 TM3 Van der Waals
neuropeptide FF Q123 3.32x32 TM3 polar (hydrogen bond)
neuropeptide FF Q123 3.32x32 TM3 Van der Waals
neuropeptide FF G124 3.33x33 TM3 Van der Waals
neuropeptide FF H188 ECL2 Van der Waals
neuropeptide FF F311 7.35x34 TM7 Van der Waals
neuropeptide FF H315 7.39x38 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 R H M H ICL1ECL1 G W P F ECL1ICL2 P F R E K L ICL2ECL2 T V T R E E H H F M V D A R N R S Y P L Y S C W E A W P E K ECL2ICL3 G G E E A ICL3ECL3 Q L S A P Q L ECL3N-term M E G E P S Q P P N S S W P L S Q N G T N T E A T P A T N L T F S S Y Y Q H T S P V N-termC-term P R P S G S H K E A Y S E R P G G L L H R R V F V V V R P S D S G L P S E S G P S S G A P R P G R L P L R N G R V A H H G L P R E G P G C S H L P L T I P A W D I C-term A A M F I V A Y A L I F L L C M V G N T L V C F I V L K N T V T N M F I L N L A V S D L L V G I F C M P T T L V D N L I T D N A T C K M S G L V Q G M S V S A S V F T L V A I A V E R F R C I V H T L R K A L V T I A V I W A L A L L I M C P S A V T L G M R R V Y T T V L F S H I Y L A P L A L I V V M Y A R I A R K L C Q A P G P A P A D P R A S R R R A R V V H M L V M V A L F F T L S W L P L W A L L L L I D Y G H L V T V Y A F P F A H W L A F F N S S A N P I I Y G Y F N E N F Q A R L C F R R G A F R A
Helix box plot — Download: PNG | SVG T N G V M C L L F I L A Y A V I F M A A 1 L N L A V S D L L V G F I C M P T T L V D 2 A V L T F V S A S V S M G Q V L G S M K 3 A L V T I A V I W A L A L L I M C P S 4 Y M V V I L A L P A L Y I H S F L V T T Y 5 V M V A L F F T L S W L P L W A L L L L 6 I P N A S S N F F A L W H A F P F A Y 7

GPCRdb(A)
GPCRdb(A)
NPFF1 receptor
TM2
2x64 2.65x64 N104
TM3
3x29 3.29x29 G120
3x32 3.32x32 Q123
3x33 3.33x33 G124
TM7
7x34 7.35x34 F311
7x38 7.39x38 H315