Refined structure (8X79) of Gs - IP receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-11-27

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 231 from structure (58.6%), 163 from model (41.4%)
Residue sidechains - 221 from structure (56.1%), 173 from model (43.9%)

REFINED GPCR RESIDUES

Residue backbones - 301 from structure (93.2%), 22 from model (6.8%)
Residue sidechains - 300 from structure (92.9%), 23 from model (7.1%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
K51G.HNR02G.hns1H02G.S1D13G.hgh4R12L16G.H4D10Y20G.h4s6Y02G.S6F08R12R17H19L20Y23G.H5GproteinY34x51H6x33E6x30R8x47R-H5x73T-P34x50L34x56F2x39S-R5x72Y34x53D34x57Q5x74Q5x70GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.HNG.hns1G.S1G.hgh4G.H4G.h4s6G.S6G.H5GPCR segments:TM2ICL2ICL3TM5TM6H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null1x571x602x372x392x403x493x503x533x543x5534x5034x5134x5334x5434x5534x5634x575x635x665x705x725x735x746x306x338x478x498x50G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.11G.H5.08G.S6.04G.S6.02G.h4s6.20G.h4s6.11G.h4s6.10G.h4s6.03G.H4.17G.H4.16G.H4.13G.H4.12G.hgh4.13G.S3.03G.S3.01G.S1.02G.hns1.03G.hns1.02G.HN.51Res. Pos.IP (8X79_REFINED)- (8X79_REFINED)-----------------------------LRSFAERALSPYYAQLDLMQRHQEHRAVLRSFAPYYAQLDERALSLMQRHQEHRAVGLQYRIQHFCHVFRAKLDRYRYHELDLRTDGD

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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