GPR12 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7Y3G

RESOLUTION

2.8 Å

REFERENCE

10.1016/J.SCIB.2022.12.023

PUBLICATION DATE

June 7, 2023

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 H 227 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 227 5x68 G.H5 Q 384 G.H5.16
Polar TM3 L 142 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 142 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 142 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 145 - G.H5 R 380 G.H5.12
Hydrophobic TM5 I 231 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM6 K 248 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 220 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 H 235 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 F 237 - G.H4 L 346 G.H4.16
Ionic TM7 R 304 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 R 304 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 R 304 7x56 G.H5 E 392 G.H5.24
Polar TM5 R 226 5x67 G.H5 Q 384 G.H5.16
Ionic TM5 R 226 5x67 G.H5 D 381 G.H5.13
Hydrophobic ICL2 L 146 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 146 - G.S1 H 41 G.S1.02
Polar TM6 T 252 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 142 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 H 227 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 142 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 146 - G.H5 R 380 G.H5.12
Polar TM3 S 141 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 141 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 141 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 146 - G.S3 V 217 G.S3.01
Hydrophobic TM5 V 224 5x65 G.H5 L 393 G.H5.25
Polar TM5 Q 230 5x71 G.H5 R 385 G.H5.17
Hydrophobic TM5 I 223 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 Q 234 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM6 L 253 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 253 6x37 G.H5 L 393 G.H5.25
Polar ICL2 S 150 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 S 150 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 E 151 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 S 150 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 V 224 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 224 5x65 G.H5 L 388 G.H5.20
Aromatic TM3 R 138 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 146 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 146 - G.H5 I 383 G.H5.15
Polar TM5 Q 234 5x75 G.S6 C 359 G.S6.01
Van-der-waals TM5 Q 234 5x75 G.S6 C 359 G.S6.01
Hydrophobic ICL2 L 146 - G.H5 C 379 G.H5.11
Hydrophobic TM5 I 231 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM5 A 228 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 231 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 231 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM6 G 249 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 G 249 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 249 6x33 G.H5 L 393 G.H5.25
Aromatic ICL2 H 149 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 149 - G.hns1 R 38 G.hns1.02
Polar TM5 H 227 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 227 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 227 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL3 F 237 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 F 237 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 A 145 - G.H5 I 383 G.H5.15
Hydrophobic TM2 M 79 2x39 G.H5 Y 391 G.H5.23
Polar TM3 S 141 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 141 3x53 G.H5 Y 391 G.H5.23
Polar TM6 K 248 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 248 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 A 145 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 146 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 146 - G.H5 F 376 G.H5.08
Hydrophobic TM6 T 252 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL3 F 237 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 F 237 - G.H4 R 347 G.H4.17
Hydrophobic TM5 H 227 5x68 G.H5 L 394 G.H5.26
Ionic TM5 H 227 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 227 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 227 5x68 G.H5 D 381 G.H5.13